Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8QGP3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8QGP3-F1 | Predicted | AlphaFoldDB |
No variants for Q8QGP3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8QGP3 | |||||
No associated diseases with Q8QGP3
1 regional properties for Q8QGP3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Peptidase M14, carboxypeptidase A | 24 - 434 | IPR000834 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metallocarboxypeptidase activity | Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| zinc ion binding | Binding to a zinc ion (Zn). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| peptide metabolic process | The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. |
| protein processing | Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. |
| Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P04836 | CPE | Carboxypeptidase E | Bos taurus (Bovine) | PR |
| Q2KJ83 | CPN1 | Carboxypeptidase N catalytic chain | Bos taurus (Bovine) | PR |
| Q8IUX7 | AEBP1 | Adipocyte enhancer-binding protein 1 | Homo sapiens (Human) | PR |
| O75976 | CPD | Carboxypeptidase D | Homo sapiens (Human) | PR |
| Q8N436 | CPXM2 | Inactive carboxypeptidase-like protein X2 | Homo sapiens (Human) | PR |
| Q96SM3 | CPXM1 | Probable carboxypeptidase X1 | Homo sapiens (Human) | PR |
| P14384 | CPM | Carboxypeptidase M | Homo sapiens (Human) | PR |
| Q66K79 | CPZ | Carboxypeptidase Z | Homo sapiens (Human) | PR |
| Q80V42 | Cpm | Carboxypeptidase M | Mus musculus (Mouse) | PR |
| O89001 | Cpd | Carboxypeptidase D | Mus musculus (Mouse) | PR |
| Q9JJN5 | Cpn1 | Carboxypeptidase N catalytic chain | Mus musculus (Mouse) | PR |
| Q9Z100 | Cpxm1 | Probable carboxypeptidase X1 | Mus musculus (Mouse) | PR |
| Q9D2L5 | Cpxm2 | Inactive carboxypeptidase-like protein X2 | Mus musculus (Mouse) | PR |
| Q640N1 | Aebp1 | Adipocyte enhancer-binding protein 1 | Mus musculus (Mouse) | PR |
| Q9EQV8 | Cpn1 | Carboxypeptidase N catalytic chain | Rattus norvegicus (Rat) | PR |
| A2RUV9 | Aebp1 | Adipocyte enhancer-binding protein 1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVPSLLLLLT | GLFRATEPAP | RCETGQETLG | QCQTAQKAKC | VDISLSSCTD | VTYTQTMYPN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FLDQKSREVI | EYSSEYILIS | VLHNLLQGEC | NPDLRLLGCS | VLAPQCEKDK | VIKPCRHVCE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NLKKNCLSAF | DAIDMAWPYF | LDCDRFFAGE | EEGCFDPLAK | LRGEVAVEED | LPSDFPATFI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QFKHHSYSQM | VSTLKKTASR | CSHIATTYSI | GRSFEGKDLF | VIEFSTKPGH | HELLKPEFKY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IGNMHGNEVV | GKELLYTLRS | ICVQKYLLGN | PRIQTLINNT | RIHLLPSLNP | DGYERAAEEG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AGYNGWVIGR | QTAQNLDLNR | NFPDLTSEAY | RRAGIRGARL | DHIPIPQSYW | WGKVAPETKA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VMKWMRSIPF | VLSASLHGGE | LVVTYPYDYS | RHPMEEKEFS | PTPDEKMFKM | LAKAYADAHP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VISDRSEHRC | GGNFVKRGGI | INGAEWYSFT | GGMADFNYLH | TNCFEVTVEV | GCEKFPLEEE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LFTIWHENRD | ALLNYMEMVH | RGIKGIVSDK | FGNPIKNARI | SVRGIQHDIT | TAADGDYWRL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LPPGTYIVTA | QAMGYTKVMK | RVTLPIKMKR | AGRVDFVLRP | IEIWPNKLLR | RPMEDMYDQY |
| 610 | 620 | 630 | 640 | ||
| DPLELFDPHA | QHAQARGGSQ | QVREKPWWWS | YFSSLDLHKP | LWLLKQH |