AiPD: Autoinhibited Protein Database

Gene name	Aebp1 (Aclp)
Protein name	Adipocyte enhancer-binding protein 1
Names	AE-binding protein 1, Aortic carboxypeptidase-like protein
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:11568
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-449 (Predicted disordered autoinhibitory region) PR

1-449 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q640N1-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs258828533	18	T>A	No	EVA
rs250492101	81	V>A	No	EVA
rs3389105279	131	K>*	No	EVA
rs3389105279	131	K>E	No	EVA
rs3389140680	132	P>T	No	EVA
rs3401592798	164	G>C	No	EVA
rs3389140738	180	L>I	No	EVA
rs3389150891	182	S>L	No	EVA
rs219910341	185	N>K	No	EVA
rs236460718	186	P>S	No	EVA
rs3389116982	188	A>T	No	EVA
rs216523670	217	P>S	No	EVA
rs3389147360	235	Q>R	No	EVA
rs8279653	242	E>A	No	EVA
rs3389129034	249	R>L	No	EVA
rs3389136961	251	K>Q	No	EVA
rs3389150871	290	P>L	No	EVA
rs3389140927	297	V>L	No	EVA
rs8279666	317	D>G	No	EVA
rs3389147347	333	K>Q	No	EVA
rs3389150857	333	K>R	No	EVA
rs3401867875	360	K>*	No	EVA
rs3389136920	361	G>S	No	EVA
rs3389139670	399	H>R	No	EVA
rs3389139655	400	G>V	No	EVA
rs3401958797	513	I>S	No	EVA
rs3401806242	516	L>P	No	EVA
rs3389143508	553	F>I	No	EVA
rs3389140864	577	R>H	No	EVA
rs3389112201	601	D>E	No	EVA
rs3389136904	692	D>N	No	EVA
rs3389150901	730	T>M	No	EVA
rs3401592865	736	R>Q	No	EVA
rs3402069528	737	A>D	No	EVA
rs3389134941	753	L>M	No	EVA
rs3389139637	762	Y>D	No	EVA
rs3389147353	783	A>P	No	EVA
rs3389134857	845	R>S	No	EVA
rs3389143362	863	S>P	No	EVA
rs3401173171	925	V>E	No	EVA
rs3389134868	966	A>V	No	EVA
rs8279706	975	R>Q	No	EVA
rs3389112214	998	P>S	No	EVA
rs248241499	1015	Q>R	No	EVA
rs3389150865	1021	R>W	No	EVA
rs218689645	1039	P>L	No	EVA
rs3389134873	1039	P>T	No	EVA
rs3389116968	1040	T>I	No	EVA
rs3389140688	1046	P>S	No	EVA
rs13471189	1057	P>L	No	EVA
rs8279707	1115	L>F	No	EVA

Type	Name	Position	InterPro Accession
domain	GPCR, rhodopsin-like, 7TM	65 - 316	IPR017452

		Description
EC Number
Subcellular Localization	[Isoform 1]: Secreted ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
calmodulin binding	Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
carboxypeptidase activity	Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain.
collagen binding	Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
DNA-binding transcription repressor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II transcription regulatory region sequence-specific DNA binding	Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
zinc ion binding	Binding to a zinc ion (Zn).

Name	Definition
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
proteolysis	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
regulation of collagen fibril organization	Any process that modulates the frequency, rate or extent of collagen fibril organization.
regulation of DNA-templated transcription	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P04836	CPE	Carboxypeptidase E	Bos taurus (Bovine)	PR
Q2KJ83	CPN1	Carboxypeptidase N catalytic chain	Bos taurus (Bovine)	PR
Q8QGP3	CPZ	Carboxypeptidase Z	Gallus gallus (Chicken)	PR
O75976	CPD	Carboxypeptidase D	Homo sapiens (Human)	PR
Q8N436	CPXM2	Inactive carboxypeptidase-like protein X2	Homo sapiens (Human)	PR
Q66K79	CPZ	Carboxypeptidase Z	Homo sapiens (Human)	PR
Q96SM3	CPXM1	Probable carboxypeptidase X1	Homo sapiens (Human)	PR
P14384	CPM	Carboxypeptidase M	Homo sapiens (Human)	PR
Q8IUX7	AEBP1	Adipocyte enhancer-binding protein 1	Homo sapiens (Human)	PR
Q80V42	Cpm	Carboxypeptidase M	Mus musculus (Mouse)	PR
Q9D2L5	Cpxm2	Inactive carboxypeptidase-like protein X2	Mus musculus (Mouse)	PR
Q9Z100	Cpxm1	Probable carboxypeptidase X1	Mus musculus (Mouse)	PR
Q9JJN5	Cpn1	Carboxypeptidase N catalytic chain	Mus musculus (Mouse)	PR
O89001	Cpd	Carboxypeptidase D	Mus musculus (Mouse)	PR
Q9EQV8	Cpn1	Carboxypeptidase N catalytic chain	Rattus norvegicus (Rat)	PR
A2RUV9	Aebp1	Adipocyte enhancer-binding protein 1	Rattus norvegicus (Rat)	PR