A2RUV9

PR
Gene name
Aebp1 (Aclp)
Protein name
Adipocyte enhancer-binding protein 1
Names
AE-binding protein 1, Aortic carboxypeptidase-like protein
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:305494
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-453 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A2RUV9

Entry ID Method Resolution Chain Position Source
AF-A2RUV9-F1 Predicted AlphaFoldDB

No variants for A2RUV9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A2RUV9

No associated diseases with A2RUV9

2 regional properties for A2RUV9

Type Name Position InterPro Accession
domain Coagulation factor 5/8 C-terminal domain 375 - 532 IPR000421
domain Peptidase M14, carboxypeptidase A 556 - 984 IPR000834

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

6 GO annotations of molecular function

Name Definition
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
carboxypeptidase activity Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain.
collagen binding Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
DNA-binding transcription repressor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II transcription regulatory region sequence-specific DNA binding Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
zinc ion binding Binding to a zinc ion (Zn).

4 GO annotations of biological process

Name Definition
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
regulation of collagen fibril organization Any process that modulates the frequency, rate or extent of collagen fibril organization.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

16 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P04836 CPE Carboxypeptidase E Bos taurus (Bovine) PR
Q2KJ83 CPN1 Carboxypeptidase N catalytic chain Bos taurus (Bovine) PR
Q8QGP3 CPZ Carboxypeptidase Z Gallus gallus (Chicken) PR
O75976 CPD Carboxypeptidase D Homo sapiens (Human) PR
Q8N436 CPXM2 Inactive carboxypeptidase-like protein X2 Homo sapiens (Human) PR
Q66K79 CPZ Carboxypeptidase Z Homo sapiens (Human) PR
Q96SM3 CPXM1 Probable carboxypeptidase X1 Homo sapiens (Human) PR
P14384 CPM Carboxypeptidase M Homo sapiens (Human) PR
Q8IUX7 AEBP1 Adipocyte enhancer-binding protein 1 Homo sapiens (Human) PR
Q80V42 Cpm Carboxypeptidase M Mus musculus (Mouse) PR
O89001 Cpd Carboxypeptidase D Mus musculus (Mouse) PR
Q9JJN5 Cpn1 Carboxypeptidase N catalytic chain Mus musculus (Mouse) PR
Q9Z100 Cpxm1 Probable carboxypeptidase X1 Mus musculus (Mouse) PR
Q9D2L5 Cpxm2 Inactive carboxypeptidase-like protein X2 Mus musculus (Mouse) PR
Q640N1 Aebp1 Adipocyte enhancer-binding protein 1 Mus musculus (Mouse) PR
Q9EQV8 Cpn1 Carboxypeptidase N catalytic chain Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAAVRTASLL CGLLALLALC PEGSPQTVLT DDEIQEFLEG FLSEFETQSP PREDDVEAQP
70 80 90 100 110 120
LPEPTQRARK SKAGGKPRAD AEAPPEKNKD KEKKGKKDKG PKAAKHLEGS TRPTKKPKEK
130 140 150 160 170 180
PPKATKKPKE KPPKATKKPK EKPPKATKKP KEKPPKATKR PSAGKRFSTV APLETPERSL
190 200 210 220 230 240
TSPSNPGTRE LPEERGRTSL NTWQGQGEET QVEARQHRPE PEEETEMPTL DYNDQIERED
250 260 270 280 290 300
YEDFEYIRRQ KQPRPTPSRK RIWPEPPEEK TQEPEERKEV DPPLKPLLPP DYGDGYLIPN
310 320 330 340 350 360
YDDLDYYFPH PPPQKPDVGQ EVDEEKEELK KPKKEGSSPK EDTEDKWAAE KNKDHKAGPR
370 380 390 400 410 420
KGEELEEEWG PVEKIKCPPI GMESHRIEDN QIRASSMLRH GLGAQRGRLN MQAGANEDDY
430 440 450 460 470 480
YDGAWCAEDE SQTQWIEVDT RRTTRFTGVI TQGRDSSIHD DFVTTFFVGF SNDSQTWVMY
490 500 510 520 530 540
TNGYEEMTFH GNVDKDTPVL SELPEPVVAR FIRIYPLTWN GSLCMRLEVL GCPVTPVYSY
550 560 570 580 590 600
YAQNEVVTTD SLDFRHHSYK DMRQLMKVVN EECPTITRTY SLGKSSRGLK IYAMEISDNP
610 620 630 640 650 660
GEHELGEPEF RYTAGMHGNE VLGRELLLLL MQYLCHEYRD GNPRVRNLVQ DTRIHLVPSL
670 680 690 700 710 720
NPDGYEVAAQ MGSEFGNWAL GLWTEEGFDI FEDFPDLNSV LWAAEEKKWV PYRVPNNNLP
730 740 750 760 770 780
IPERYLSPDA TVSTEVRAII SWMEKNPFVL GANLNGGERL VSYPYDMART PSQEQLLAAA
790 800 810 820 830 840
LAAARGEDED EVSEAQETPD HAIFRWLAIS FASAHLTMTE PYRGGCQAQD YTSGMGIVNG
850 860 870 880 890 900
AKWNPRSGTF NDFSYLHTNC LELSIYLGCD KFPHESELPR EWENNKEALL TFMEQVHRGI
910 920 930 940 950 960
KGVVTDEQGI PIANATISVS GINHGVKTAS GGDYWRILNP GEYRVTAHAE GYTSSAKICN
970 980 990 1000 1010 1020
VDYDIGATQC NFILARSNWK RIREILAMNG NRPILRVDPS RPMTPQQRRL QQRRLRYRLR
1030 1040 1050 1060 1070 1080
MREQMRLRRL NSTTGPATSP TPALTLPPSP TPGSTSRLWE ILPTTAAGWE ESETETYTEV
1090 1100 1110 1120
VTEFETEYGP DLEVEELEEE EEEEEEMDTG LTFPVTTVET YTVNFGDF