Q9D9Q6
Gene name |
Calr3 (Crt2) |
Protein name |
Calreticulin-3 |
Names |
Calreticulin-2, Calsperin |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:73316 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9D9Q6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9D9Q6-F1 | Predicted | AlphaFoldDB |
11 variants for Q9D9Q6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388973677 | 78 | S>A | No | EVA | |
| rs3388995175 | 93 | I>F | No | EVA | |
| rs3388995195 | 143 | K>N | No | EVA | |
| rs3388973691 | 174 | L>P | No | EVA | |
| rs229557499 | 206 | R>K | No | EVA | |
| rs217044355 | 214 | D>E | No | EVA | |
| rs3388944161 | 220 | Q>K | No | EVA | |
| rs1132858014 | 236 | A>V | No | EVA | |
| rs3388979479 | 267 | I>F | No | EVA | |
| rs3388992281 | 365 | F>I | No | EVA | |
| rs13470508 | 371 | F>L | No | EVA |
No associated diseases with Q9D9Q6
2 regional properties for Q9D9Q6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Pentatricopeptide repeat | 314 - 338 | IPR002885-1 |
| repeat | Pentatricopeptide repeat | 347 - 381 | IPR002885-2 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum lumen | The volume enclosed by the membranes of the endoplasmic reticulum. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| protein folding chaperone | Binding to a protein or a protein-containing complex to assist the protein folding process. |
| unfolded protein binding | Binding to an unfolded protein. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
| ubiquitin-dependent ERAD pathway | The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P52193 | CALR | Calreticulin | Bos taurus (Bovine) | PR |
| Q2TBR8 | CALR3 | Calreticulin-3 | Bos taurus (Bovine) | PR |
| P29413 | Calr | Calreticulin | Drosophila melanogaster (Fruit fly) | PR |
| P27797 | CALR | Calreticulin | Homo sapiens (Human) | PR |
| Q96L12 | CALR3 | Calreticulin-3 | Homo sapiens (Human) | PR |
| P14211 | Calr | Calreticulin | Mus musculus (Mouse) | PR |
| P52194 | Clgn | Calmegin | Mus musculus (Mouse) | PR |
| P28491 | CALR | Calreticulin | Sus scrofa (Pig) | PR |
| P18418 | Calr | Calreticulin | Rattus norvegicus (Rat) | PR |
| Q9SLY8 | CRO1 | Calreticulin | Oryza sativa subsp japonica (Rice) | PR |
| P27798 | crt-1 | Calreticulin | Caenorhabditis elegans | PR |
| Q7Z1E6 | crt | Calreticulin | Bombyx mori (Silk moth) | PR |
| Q38858 | CRT2 | Calreticulin-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O04151 | CRT1 | Calreticulin-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O04153 | CRT3 | Calreticulin-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVSARALLWA | ICVLRVALAT | VYFQEEFLDG | ERWRNRWVQS | TNDSQFGHFR | VSSGKFYGHK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EKDKGLQTTQ | NSRFYAISAS | FKPFSNKGKT | LVIQYTVKHE | QKMDCGGGYI | KVFPSDLDQK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KMNGKSQYYI | MFGPDICGFD | IKKVHVILYF | KNQYHENKKP | IRCKVDGFTH | LYTLILRPDL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SYEVKVDGQS | IESGSIEYDW | NLTSLRKTEK | TSLDSRDWDQ | VEGSKVQDWE | KHFLDAGASK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PSDWNSELDG | DWLQKPPYED | GLKAEGIDKD | VWLHQKMRPA | GYLTQYDLSE | FENIGAIGLE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LWQVRSGTIF | DNFLITDDEE | YAEKFGKATW | GETKGPEKEM | DAIQAKEEVK | KAREEDEEDL |
| 370 | |||||
| LMGKFHRHNH | FSRFHRQGEL |