AiPD: Autoinhibited Protein Database

P27797

Gene name	CALR
Protein name	Calreticulin
Names	CRP55, Calregulin, Endoplasmic reticulum resident protein 60, ERp60, HACBP, grp60
Species	Homo sapiens (Human)
KEGG Pathway	hsa:811
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

334-417 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

334-417 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

11 structures for P27797

Entry ID	Method	Resolution	Chain	Position	Source
2CLR	X-ray	200 A	C/F	1-10	PDB
3DOW	X-ray	230 A	B	195-205	PDB
3POS	X-ray	165 A			PDB
3POW	X-ray	155 A			PDB
5LK5	X-ray	230 A			PDB
5V90	X-ray	325 A	B/D	238-273	PDB
6ENY	EM	580 A	G	18-417	PDB
7QPD	EM	373 A	C	18-417	PDB
8TZO	EM	310 A	C	1-417	PDB
8TZR	EM	350 A	C	1-417	PDB
AF-P27797-F1	Predicted				AlphaFoldDB

328 variants for P27797

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV000083257 rs1555760738 RCV002498437 RCV000083256	367	L>missing	Primary myelofibrosis Thrombocythemia 1 [ClinVar]	Yes	ClinVar dbSNP
rs765476509 RCV001329863	385	K>missing	Thrombocythemia 1 [ClinVar]	Yes	ClinVar dbSNP
rs777358098 CA9235597	3	L>R		No	ClinGen ExAC gnomAD
rs1397929746 CA404300543	4	S>P		No	ClinGen gnomAD
TCGA novel	5	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	5	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756694331 CA9235599	6	P>A		No	ClinGen ExAC gnomAD
CA9235600 rs780662640	6	P>L		No	ClinGen ExAC TOPMed gnomAD
rs941288230 CA305513269	8	L>V		No	ClinGen TOPMed gnomAD
rs770160684 CA9235605	11	L>F		No	ClinGen ExAC gnomAD
rs763131258 CA9235607	12	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	12	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA305513317 rs929780860	13	G>C		No	ClinGen Ensembl
rs1378379005 CA404300933	15	A>G		No	ClinGen gnomAD
rs1378379005 CA404300941	15	A>V		No	ClinGen gnomAD
rs1176515855 CA404300965	16	V>I		No	ClinGen gnomAD
CA9235613 rs147368353	17	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9235612 rs752512916	17	A>T		No	ClinGen ExAC gnomAD
CA9235614 rs147368353	17	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs775581620 CA305513366	18	E>Q		No	ClinGen TOPMed
rs1405396151 CA404301065	19	P>L		No	ClinGen gnomAD
CA404301222 rs1371775156	23	F>L		No	ClinGen gnomAD
rs541091872 CA9235615	24	K>N		No	ClinGen 1000Genomes ExAC gnomAD
CA404301269 rs1223633950	24	K>R		No	ClinGen gnomAD
CA404301331 rs1207532147	26	Q>K		No	ClinGen gnomAD
rs1236351578 CA404301472	30	G>A		No	ClinGen gnomAD
rs1199946705 CA404301466 CA404301457	30	G>R		No	ClinGen TOPMed gnomAD
rs146793150 CA9235648	31	D>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9235649 rs146793150	31	D>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9235652 rs140472880	32	G>A		No	ClinGen ESP ExAC TOPMed
CA305513871 CA9235651 rs377744854	32	G>R		No	ClinGen ExAC TOPMed gnomAD
rs764831280 CA404301869	34	T>I		No	ClinGen ExAC gnomAD
rs764831280 CA9235653	34	T>N		No	ClinGen ExAC gnomAD
CA404302191 rs1448209762	41	K>N		No	ClinGen gnomAD
rs1285438952 CA404302217	42	H>L		No	ClinGen gnomAD
TCGA novel	42	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9235657 rs753324324	45	D>G		No	ClinGen ExAC TOPMed gnomAD
rs753324324 CA9235658	45	D>V		No	ClinGen ExAC TOPMed gnomAD
CA404302515 rs764612484	50	V>F		No	ClinGen ExAC gnomAD
CA9235659 rs764612484	50	V>L		No	ClinGen ExAC gnomAD
CA404302552 rs1315949624	51	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA404302601 rs1282502862	52	S>N		No	ClinGen gnomAD
CA404302602 rs1282502862	52	S>T		No	ClinGen gnomAD
COSM1711886 rs757608389 CA9235661	56	F>L	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs200631709 CA404302726	57	Y>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9235662 rs138503495 RCV000943310	57	Y>C		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA9235664 rs758537042	58	G>R		No	ClinGen ExAC gnomAD
rs780108025 CA9235665	59	D>N		No	ClinGen ExAC TOPMed gnomAD
rs550300014 CA9235667	60	E>D		No	ClinGen 1000Genomes ExAC gnomAD
rs1383867644 CA404302896	62	K>E		No	ClinGen gnomAD
rs1335654763 CA404302947	63	D>N		No	ClinGen gnomAD
TCGA novel	65	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765669613 CA305514147	67	Q>*		No	ClinGen Ensembl
CA404303351 rs1274707844	67	Q>R		No	ClinGen TOPMed
rs1404498335 CA404303463	71	D>G		No	ClinGen gnomAD
rs1228790764 CA404303481	72	A>T		No	ClinGen TOPMed
CA404303490 rs1278938364	72	A>V		No	ClinGen gnomAD
CA305514151 rs370585408	73	R>C		No	ClinGen ESP
rs1309384945 CA404303532	74	F>L		No	ClinGen gnomAD
CA305514171 rs528652331	76	A>G		No	ClinGen 1000Genomes
CA404303631 rs1328767759	77	L>V		No	ClinGen TOPMed
CA404303672 rs1216454628	79	A>V		No	ClinGen gnomAD
CA404303691 rs777068782	80	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1599659411 CA404303699	80	S>R		No	ClinGen Ensembl
CA9235697 rs777068782	80	S>T		No	ClinGen ExAC TOPMed gnomAD
CA305514197 rs11547568	81	F>L		No	ClinGen Ensembl
rs762383116 CA9235698	83	P>A		No	ClinGen ExAC gnomAD
CA9235699 rs765669905	83	P>R		No	ClinGen ExAC gnomAD
rs1490093056 CA404303939	89	Q>*		No	ClinGen gnomAD
CA9235701 rs763267459	89	Q>H		No	ClinGen ExAC gnomAD
rs1193873308 CA404303952	89	Q>R		No	ClinGen gnomAD
CA9235702 rs766631731	90	T>A		No	ClinGen ExAC gnomAD
rs373993748 CA9235703	90	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9235706 rs752653131	92	V>L		No	ClinGen ExAC gnomAD
rs370869315 CA9235708	93	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA9235709 rs370869315	93	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs770825346 CA9235710	96	T>M		No	ClinGen ExAC gnomAD
rs1380658532 CA404304150	97	V>M		No	ClinGen gnomAD
CA9235713 rs771554069	103	I>F		No	ClinGen ExAC gnomAD
TCGA novel	103	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9235714 rs775075277	105	C>Y		No	ClinGen ExAC
CA9235717 rs773681781	110	V>M		No	ClinGen ExAC gnomAD
rs763359131 CA9235718	112	L>M		No	ClinGen ExAC TOPMed gnomAD
rs1440405540 CA404305286	113	F>L		No	ClinGen TOPMed
rs550682309 CA9235721	114	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs550682309 CA9235720	114	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1599659517 CA404305337	115	N>S		No	ClinGen Ensembl
rs1599659521 CA404305350	116	S>G		No	ClinGen Ensembl
CA404305410 rs1181727268	118	D>E		No	ClinGen gnomAD
rs201017921 CA9235723	118	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1599659539 CA404305459	120	T>K		No	ClinGen Ensembl
CA404305506 rs1440152184	122	M>K		No	ClinGen gnomAD
CA9235724 rs756230073	122	M>V		No	ClinGen ExAC TOPMed gnomAD
CA9235725 rs764176324	124	G>R		No	ClinGen ExAC TOPMed gnomAD
CA9235726 rs753812197	125	D>E		No	ClinGen ExAC TOPMed gnomAD
rs536586990 CA305514371	126	S>L		No	ClinGen Ensembl
CA9235728 rs375318260	127	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
COSM991544 CA305514389 rs200421584	128	Y>C	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes NCI-TCGA
rs778770240 CA9235729	129	N>D		No	ClinGen ExAC gnomAD
CA9235730 rs200105930	129	N>I		No	ClinGen ExAC gnomAD
rs1174378826 CA404306017	134	P>S		No	ClinGen gnomAD
TCGA novel	134	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9235759 rs775846295	136	I>V		No	ClinGen ExAC gnomAD
CA404306091 rs1425763533	138	G>R		No	ClinGen TOPMed
rs1482810500 CA404306110	139	P>L		No	ClinGen TOPMed
rs1353262366 CA404306106	139	P>S		No	ClinGen TOPMed gnomAD
rs761940782 CA9235763	141	T>S		No	ClinGen ExAC
CA9235764 rs765257046	143	K>N		No	ClinGen ExAC gnomAD
CA305514903 rs149216548	144	V>I		No	ClinGen ESP TOPMed gnomAD
CA9235765 rs750310401	147	I>V		No	ClinGen ExAC
rs1316053037 CA404306303	149	N>K		No	ClinGen TOPMed
rs762866016 CA9235766	149	N>S		No	ClinGen ExAC TOPMed gnomAD
CA305514908 rs192388573	151	K>Q		No	ClinGen 1000Genomes TOPMed gnomAD
CA404306343 rs1270879893	151	K>R		No	ClinGen gnomAD
CA404306358 rs1244932238	152	G>S		No	ClinGen TOPMed
CA9235769 rs754640343	153	K>E		No	ClinGen ExAC gnomAD
CA9235771 rs752236819	154	N>D		No	ClinGen ExAC gnomAD
rs143361476 CA9235772	154	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA305514951 rs898685637	155	V>M		No	ClinGen TOPMed gnomAD
CA9235775 rs772561689	158	N>D		No	ClinGen ExAC TOPMed gnomAD
CA404306515 rs772561689	158	N>Y		No	ClinGen ExAC TOPMed gnomAD
rs780575677 CA9235776	160	D>N		No	ClinGen ExAC TOPMed gnomAD
rs769026163 CA9235778	161	I>V		No	ClinGen ExAC TOPMed gnomAD
rs776958612 CA9235779	162	R>C		No	ClinGen ExAC TOPMed gnomAD
CA9235780 rs532726457	162	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9235805 rs148345745	165	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA404306873 rs775197304	167	E>D		No	ClinGen ExAC gnomAD
CA9235807 rs760256751	168	F>L		No	ClinGen ExAC gnomAD
CA9235808 rs763749997	169	T>I		No	ClinGen ExAC gnomAD
rs11547569 CA9235814	176	V>M		No	ClinGen ExAC gnomAD
rs1031122373 CA305515275	177	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA404307070 rs1451773406	177	R>W		No	ClinGen TOPMed gnomAD
CA404307090 rs1353439888	178	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA305515281 rs956997728	179	D>G		No	ClinGen TOPMed gnomAD
CA404307135 rs1486461030	180	N>T		No	ClinGen Ensembl
rs1439711150 CA404307162	181	T>I		No	ClinGen gnomAD
rs756312947 CA9235816	186	I>T		No	ClinGen ExAC gnomAD
rs1224218038 CA404307286	188	N>S		No	ClinGen gnomAD
CA9235818 rs147369833	189	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs147369833 CA9235817	189	S>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	190	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404307351 rs1599660037	191	V>M		No	ClinGen Ensembl
CA9235820 rs774337397	192	E>D		No	ClinGen ExAC TOPMed gnomAD
CA404307422 rs1236632838	193	S>F		No	ClinGen TOPMed gnomAD
rs771939411 CA9235822	194	G>S		No	ClinGen ExAC gnomAD
rs775169572 CA9235823	196	L>V		No	ClinGen ExAC gnomAD
rs199565419 CA404307560	199	D>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9235825 rs199565419	199	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA404307546 rs199565419	199	D>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1012156672 CA305515368	201	D>E		No	ClinGen TOPMed gnomAD
rs1371727784 CA404307654	202	F>L		No	ClinGen Ensembl
CA9235828 rs79497711	202	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs749888508 CA9235829	205	P>S		No	ClinGen ExAC gnomAD
TCGA novel	206	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9235831 rs534189742	208	I>M		No	ClinGen 1000Genomes ExAC gnomAD
CA9235830 rs755559115	208	I>V		No	ClinGen ExAC gnomAD
rs753035212 CA9235832	209	K>T		No	ClinGen ExAC gnomAD
CA9235833 rs756471809	210	D>H		No	ClinGen ExAC
CA404307919 rs1285301824	211	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs970377727 CA305515386	212	D>V		No	ClinGen TOPMed
rs369547041 CA9235834	213	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA404307972 rs1232585250	213	A>V		No	ClinGen TOPMed gnomAD
CA404307987 rs1599660098	214	S>A		No	ClinGen Ensembl
rs200173883 CA9235835	216	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1194438507 CA404308098	217	E>K		No	ClinGen gnomAD
rs745898206 CA9235838	218	D>N		No	ClinGen ExAC
rs1490417226 CA404308232	221	E>K		No	ClinGen gnomAD
CA404308277 rs371806484	222	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA9235840 rs371806484	222	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA9235839 rs764695158	222	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs139658454 CA404308364	225	I>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs746826200 CA9235841	225	I>S		No	ClinGen ExAC TOPMed gnomAD
CA404308388 rs938433963	226	D>H		No	ClinGen TOPMed gnomAD
rs938433963 CA305515470	226	D>N		No	ClinGen TOPMed gnomAD
rs938433963 CA404308392	226	D>Y		No	ClinGen TOPMed gnomAD
CA404308422 rs1599660153	227	D>H		No	ClinGen Ensembl
rs1056862836 CA305515474	227	D>V		No	ClinGen Ensembl
CA9235843 rs149740908	228	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA305515475 rs1012573592	233	P>L		No	ClinGen TOPMed gnomAD
TCGA novel	234	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404308752 rs1599660258	235	D>N		No	ClinGen Ensembl
CA9235872 rs762130142	235	D>V		No	ClinGen ExAC TOPMed
CA305515731 rs1019627616	240	E>K		No	ClinGen TOPMed gnomAD
CA404308943 rs1239263833	243	P>A		No	ClinGen gnomAD
rs559703788 CA9235874	243	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA404309015 rs1328636364	245	P>L		No	ClinGen TOPMed
rs1268034614 CA404309006	245	P>S		No	ClinGen gnomAD
CA9235877 rs751538049	247	A>T		No	ClinGen ExAC gnomAD
rs754969766 CA9235878	250	P>T		No	ClinGen ExAC
rs755951120 CA9235881	251	E>K		No	ClinGen ExAC TOPMed gnomAD
CA9235882 rs777628969	255	E>D		No	ClinGen ExAC gnomAD
CA404310419 rs1160175170	255	E>G		No	ClinGen gnomAD
rs748946100 CA9235883	256	E>K		No	ClinGen ExAC gnomAD
CA9235884 rs371463754	257	M>I		No	ClinGen ESP ExAC gnomAD
CA404310475 rs1158435388	257	M>L		No	ClinGen gnomAD
TCGA novel	258	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	260	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1378951956 CA404310588	260	E>G		No	ClinGen gnomAD
rs148447453 CA9235886	263	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA404310678 rs769245573	263	P>L		No	ClinGen ExAC TOPMed gnomAD
CA9235887 rs769245573	263	P>R		No	ClinGen ExAC TOPMed gnomAD
rs148447453 CA404310670	263	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1227247334 CA404310712	264	P>S		No	ClinGen TOPMed gnomAD
CA305516892 rs372688428	266	I>M		No	ClinGen Ensembl
CA9235889 rs777096782	270	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1226804338 CA404310823	271	Y>C		No	ClinGen TOPMed
rs1325628287 CA404310836	272	K>E		No	ClinGen gnomAD
CA305517120 rs367922867	273	G>R		No	ClinGen ESP TOPMed gnomAD
rs367922867 CA404310979	273	G>S		No	ClinGen ESP TOPMed gnomAD
CA9235911 rs766667846	273	G>V		No	ClinGen ExAC gnomAD
TCGA novel	274	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774414495 CA9235912	274	E>K		No	ClinGen ExAC TOPMed gnomAD
rs767701623 CA404311128	278	R>P		No	ClinGen ExAC TOPMed gnomAD
CA9235914 rs767701623	278	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs759720623 CA9235913	278	R>W		No	ClinGen ExAC TOPMed gnomAD
CA404311163 rs1433719863	279	Q>H		No	ClinGen TOPMed
CA305517174 rs907856910	279	Q>R		No	ClinGen TOPMed gnomAD
CA404311192 rs1273674394	280	I>T		No	ClinGen gnomAD
rs752760579 CA9235915	280	I>V		No	ClinGen ExAC gnomAD
CA9235918 rs753706198	281	D>N		No	ClinGen ExAC TOPMed gnomAD
CA404311339 rs1298450974	284	D>A		No	ClinGen TOPMed
CA9235919 rs756980463	285	Y>H		No	ClinGen ExAC gnomAD
CA9235920 rs778680432	287	G>D		No	ClinGen ExAC gnomAD
CA9235921 rs778680432	287	G>V		No	ClinGen ExAC gnomAD
rs940720149 CA305517266	288	T>S		No	ClinGen TOPMed
CA404311590 rs1568448756	292	P>L		No	ClinGen Ensembl
CA404311634 rs1359004353	294	I>M		No	ClinGen TOPMed
CA9235922 rs757976423	294	I>T		No	ClinGen ExAC gnomAD
CA9235924 rs746475957	295	D>E		No	ClinGen ExAC gnomAD
CA9235923 rs779550076	295	D>N		No	ClinGen ExAC gnomAD
CA9235925 rs770320546	297	P>H		No	ClinGen ExAC TOPMed gnomAD
rs1158895651 CA404311693	297	P>T		No	ClinGen TOPMed
COSM709890 rs1486495406 CA404311728	298	E>*	lung [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1486495406 CA404311722	298	E>K		No	ClinGen TOPMed gnomAD
rs749715575 CA9235927	301	P>L		No	ClinGen ExAC TOPMed gnomAD
CA9235930 rs759684254	302	D>G		No	ClinGen ExAC
CA9235929 rs375135016	302	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs772370252 CA9235931	303	P>R		No	ClinGen ExAC TOPMed
rs775741226 CA9235932	304	S>G		No	ClinGen ExAC gnomAD
CA9235934 rs764176358	306	Y>H		No	ClinGen ExAC gnomAD
rs1345312350 CA404311954	307	A>D		No	ClinGen TOPMed gnomAD
CA305517330 rs964090332	307	A>S		No	ClinGen Ensembl
rs1345312350 CA404311951	307	A>V		No	ClinGen TOPMed gnomAD
rs1364364542 CA404312019	309	D>G		No	ClinGen gnomAD
rs1318523776 CA404312001	309	D>N		No	ClinGen TOPMed gnomAD
rs1026947469 CA305517340	313	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs372777769 CA305517346	318	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA9235943 rs372777769	318	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA404314295 rs1336604811	322	K>E		No	ClinGen gnomAD
rs748221094 CA9235972	326	I>V		No	ClinGen ExAC gnomAD
rs1156624733 CA404314557	330	F>C		No	ClinGen TOPMed
CA404314564 rs769661818 CA9235973	330	F>L		No	ClinGen ExAC TOPMed gnomAD
CA404314569 rs1200997295	331	L>F		No	ClinGen TOPMed
CA404314574 rs1466726242	331	L>H		No	ClinGen TOPMed
rs368136620 CA9235975	332	I>V		No	ClinGen ESP ExAC gnomAD
rs1282517726 CA404314637	335	D>E		No	ClinGen TOPMed
rs530463916 CA9235978	335	D>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs530463916 CA9235977	335	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	336	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA305519978 rs889138519	337	A>V		No	ClinGen gnomAD
CA404314670 rs1346217838	338	Y>C		No	ClinGen TOPMed
TCGA novel	338	Y>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1200295838 CA404314680	339	A>T		No	ClinGen gnomAD
CA305519999 rs570289702	340	E>D		No	ClinGen 1000Genomes
rs1477630481 CA404314831	344	N>D		No	ClinGen gnomAD
rs755626585 CA9235981	344	N>S		No	ClinGen ExAC TOPMed gnomAD
rs750961102 CA9235983	345	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA9235985 rs758904907	346	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	347	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1405633070 CA404314968	348	G>D		No	ClinGen gnomAD
CA9235986 rs780575601	348	G>S		No	ClinGen ExAC gnomAD
CA9235988 rs144233437	349	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs144233437 CA404314988	349	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1174226840 CA404315081	351	K>N		No	ClinGen TOPMed
rs1359478180 CA404315220	353	A>T		No	ClinGen TOPMed
rs781327462 CA9236008	356	Q>E		No	ClinGen ExAC gnomAD
rs1161377561 CA404315464	361	Q>L		No	ClinGen gnomAD
CA305520280 rs151032910	362	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	362	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404315514 rs1167230978	363	E>K		No	ClinGen TOPMed gnomAD
CA404315556 rs1457476768	364	E>K		No	ClinGen gnomAD
rs749320321 CA9236013	365	Q>H		No	ClinGen ExAC gnomAD
CA9236014 rs770889031	367	L>H		No	ClinGen ExAC gnomAD
CA9236016 rs778797734	368	K>E		No	ClinGen ExAC TOPMed gnomAD
CA305520337 rs901041813	370	E>V		No	ClinGen TOPMed
CA305520374 rs554136219	371	E>A		No	ClinGen Ensembl
CA404315760 rs1568449692	372	E>K		No	ClinGen Ensembl
CA404315792 rs1339443654	373	D>A		No	ClinGen gnomAD
CA9236019 rs771893435	373	D>N		No	ClinGen ExAC TOPMed gnomAD
CA9236021 rs775075852 COSM3720638	374	K>R	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA9236022 rs760388477	376	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1208070437 CA404315862	376	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA404315923 rs1305817662	378	E>G		No	ClinGen TOPMed
rs201971744 CA9236025	380	E>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs143880510 CA9236026 RCV000950840	381	E>A		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA9236028 rs370029737	384	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA9236027 rs761374568	384	D>N		No	ClinGen ExAC gnomAD
CA9236031 rs535789821	385	K>E		No	ClinGen 1000Genomes ExAC gnomAD
rs1159150142 CA404316170	385	K>N		No	ClinGen gnomAD
rs1024435400 CA305520473	385	K>T		No	ClinGen TOPMed
CA404316172 rs1276401921	386	E>K		No	ClinGen gnomAD
rs765059081 CA9236033	387	D>E		No	ClinGen ExAC gnomAD
CA404316214 rs1360248191	387	D>V		No	ClinGen gnomAD
CA305520503 rs971167629	388	D>Y		No	ClinGen TOPMed
CA9236038 rs752951204	391	K>E		No	ClinGen ExAC gnomAD
CA404316564 rs1283919745	396	E>K		No	ClinGen gnomAD
CA404316574 rs1313827767	396	E>V		No	ClinGen gnomAD
rs1037708390 CA404316611	397	D>E		No	ClinGen TOPMed
CA9236044 rs777934720	397	D>G		No	ClinGen ExAC gnomAD
COSM1738023 CA404316632 rs1264674656	398	E>D	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA9236047 rs150264068	398	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1222423364 CA404316664	400	D>V		No	ClinGen TOPMed
TCGA novel	401	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1471691318 CA404316710	402	E>Q		No	ClinGen gnomAD
CA404316771 rs1599662588	404	D>N		No	ClinGen Ensembl
rs1426498732 CA404316795	405	E>K		No	ClinGen gnomAD
CA404316819 rs1174438067	406	E>K		No	ClinGen TOPMed gnomAD
CA404316910 rs745819141	409	V>A		No	ClinGen ExAC TOPMed gnomAD
CA9236052 rs745819141	409	V>G		No	ClinGen ExAC TOPMed gnomAD
rs866651711 CA305520645	410	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA404316917 rs1368310230	410	P>S		No	ClinGen gnomAD
CA305520659 rs746740154	411	G>R		No	ClinGen ExAC TOPMed gnomAD
rs746740154 CA9236055	411	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA404316988 rs1300480978	413	A>D		No	ClinGen TOPMed gnomAD
rs1300480978 CA404316991	413	A>V		No	ClinGen TOPMed gnomAD
CA9236058 rs148604761	415	D>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs769424711 CA9236059	416	E>K		No	ClinGen ExAC TOPMed gnomAD
CA404317051 rs1482164699	417	L>P		No	ClinGen gnomAD

1 associated diseases with P27797

Without disease ID

3 regional properties for P27797

Type	Name	Position	InterPro Accession
conserved_site	Calreticulin/calnexin, conserved site	98 - 113	IPR018124-1
conserved_site	Calreticulin/calnexin, conserved site	130 - 138	IPR018124-2
conserved_site	Calreticulin/calnexin, conserved site	242 - 254	IPR018124-3

Functions

		Description
EC Number
Subcellular Localization	Endoplasmic reticulum lumen Cytoplasm, cytosol Secreted, extracellular space, extracellular matrix Cell surface Sarcoplasmic reticulum lumen Cytoplasmic vesicle, secretory vesicle, Cortical granule Cytolytic granule	Also found in cell surface (T cells), cytosol and extracellular matrix (PubMed:10358038) During oocyte maturation and after parthenogenetic activation accumulates in cortical granules In pronuclear and early cleaved embryos localizes weakly to cytoplasm around nucleus and more strongly in the region near the cortex (By similarity) In cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

29 GO annotations of cellular component

Name	Definition
acrosomal vesicle	A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
cell surface	The external part of the cell wall and/or plasma membrane.
collagen-containing extracellular matrix	An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
cortical granule	A secretory vesicle that is stored under the cell membrane of an egg. These vesicles fuse with the egg plasma membrane as part of egg activation and are part of the block to polyspermy.
cytolytic granule	A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endocytic vesicle lumen	The volume enclosed by the membrane of an endocytic vesicle.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum lumen	The volume enclosed by the membranes of the endoplasmic reticulum.
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
endoplasmic reticulum quality control compartment	A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins.
endoplasmic reticulum-Golgi intermediate compartment membrane	The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system.
external side of plasma membrane	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
focal adhesion	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
integral component of lumenal side of endoplasmic reticulum membrane	The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the lumenal side of the membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
MHC class I peptide loading complex	A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.
nuclear envelope	The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
phagocytic vesicle membrane	The lipid bilayer surrounding a phagocytic vesicle.
polysome	A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro.
sarcoplasmic reticulum lumen	The volume enclosed by the membranes of the sarcoplasmic reticulum.
smooth endoplasmic reticulum	The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.

16 GO annotations of molecular function

Name	Definition
calcium ion binding	Binding to a calcium ion (Ca2+).
carbohydrate binding	Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
chaperone binding	Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
complement component C1q complex binding	Binding to a C1q complex, a component of the classical complement cascade.
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
hormone binding	Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor.
integrin binding	Binding to an integrin.
iron ion binding	Binding to an iron (Fe) ion.
mRNA binding	Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
nuclear androgen receptor binding	Binding to a nuclear androgen receptor.
peptide binding	Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds.
protein folding chaperone	Binding to a protein or a protein-containing complex to assist the protein folding process.
RNA binding	Binding to an RNA molecule or a portion thereof.
ubiquitin protein ligase binding	Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.
unfolded protein binding	Binding to an unfolded protein.
zinc ion binding	Binding to a zinc ion (Zn).

40 GO annotations of biological process

Name	Definition
cardiac muscle cell differentiation	The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
cellular calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
cellular response to electrical stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.
cellular response to lithium ion	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus.
cellular response to virus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
cellular senescence	A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.
cortical actin cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
glucocorticoid receptor signaling pathway	The series of molecular signals initiated by glucocorticoid binding to its receptor.
negative regulation of DNA-templated transcription	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of intracellular steroid hormone receptor signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.
negative regulation of neuron differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
negative regulation of retinoic acid receptor signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
negative regulation of translation	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
negative regulation of trophoblast cell migration	Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration.
peptide antigen assembly with MHC class I protein complex	The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules.
positive regulation of cell cycle	Any process that activates or increases the rate or extent of progression through the cell cycle.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of dendritic cell chemotaxis	Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis.
positive regulation of endothelial cell migration	Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
positive regulation of gene expression	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of NIK/NF-kappaB signaling	Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.
positive regulation of phagocytosis	Any process that activates or increases the frequency, rate or extent of phagocytosis.
positive regulation of substrate adhesion-dependent cell spreading	Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading.
protein export from nucleus	The directed movement of a protein from the nucleus into the cytoplasm.
protein folding	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
protein folding in endoplasmic reticulum	A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation).
protein localization to nucleus	A process in which a protein transports or maintains the localization of another protein to the nucleus.
protein maturation by protein folding	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein.
protein stabilization	Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
regulation of apoptotic process	Any process that modulates the occurrence or rate of cell death by apoptotic process.
regulation of DNA-templated transcription	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of meiotic nuclear division	Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes.
response to estradiol	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
response to glycoside	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoside stimulus.
response to testosterone	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
response to xenobiotic stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
sequestering of calcium ion	The process of binding or confining calcium ions such that they are separated from other components of a biological system.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.
ubiquitin-dependent ERAD pathway	The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.

16 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2TBR8	CALR3	Calreticulin-3	Bos taurus (Bovine)	PR
P52193	CALR	Calreticulin	Bos taurus (Bovine)	PR
P29413	Calr	Calreticulin	Drosophila melanogaster (Fruit fly)	PR
Q96L12	CALR3	Calreticulin-3	Homo sapiens (Human)	PR
O14967	CLGN	Calmegin	Homo sapiens (Human)	PR
P27824	CANX	Calnexin	Homo sapiens (Human)	PR
P14211	Calr	Calreticulin	Mus musculus (Mouse)	PR
Q9D9Q6	Calr3	Calreticulin-3	Mus musculus (Mouse)	PR
P28491	CALR	Calreticulin	Sus scrofa (Pig)	PR
P18418	Calr	Calreticulin	Rattus norvegicus (Rat)	PR
Q9SLY8	CRO1	Calreticulin	Oryza sativa subsp japonica (Rice)	PR
P27798	crt-1	Calreticulin	Caenorhabditis elegans	PR
Q7Z1E6	crt	Calreticulin	Bombyx mori (Silk moth)	PR
Q38858	CRT2	Calreticulin-2	Arabidopsis thaliana (Mouse-ear cress)	PR
O04151	CRT1	Calreticulin-1	Arabidopsis thaliana (Mouse-ear cress)	PR
O04153	CRT3	Calreticulin-3	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MLLSVPLLLG	LLGLAVAEPA	VYFKEQFLDG	DGWTSRWIES	KHKSDFGKFV	LSSGKFYGDE
70	80	90	100	110	120
EKDKGLQTSQ	DARFYALSAS	FEPFSNKGQT	LVVQFTVKHE	QNIDCGGGYV	KLFPNSLDQT
130	140	150	160	170	180
DMHGDSEYNI	MFGPDICGPG	TKKVHVIFNY	KGKNVLINKD	IRCKDDEFTH	LYTLIVRPDN
190	200	210	220	230	240
TYEVKIDNSQ	VESGSLEDDW	DFLPPKKIKD	PDASKPEDWD	ERAKIDDPTD	SKPEDWDKPE
250	260	270	280	290	300
HIPDPDAKKP	EDWDEEMDGE	WEPPVIQNPE	YKGEWKPRQI	DNPDYKGTWI	HPEIDNPEYS
310	320	330	340	350	360
PDPSIYAYDN	FGVLGLDLWQ	VKSGTIFDNF	LITNDEAYAE	EFGNETWGVT	KAAEKQMKDK
370	380	390	400	410
QDEEQRLKEE	EEDKKRKEEE	EAEDKEDDED	KDEDEEDEED	KEEDEEEDVP	GQAKDEL