P52193
Gene name |
CALR (CRT) |
Protein name |
Calreticulin |
Names |
CRP55, Calregulin, HACBP |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:281036 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P52193
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P52193-F1 | Predicted | AlphaFoldDB |
No variants for P52193
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P52193 | |||||
No associated diseases with P52193
3 regional properties for P52193
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Calreticulin/calnexin, conserved site | 98 - 113 | IPR018124-1 |
| conserved_site | Calreticulin/calnexin, conserved site | 130 - 138 | IPR018124-2 |
| conserved_site | Calreticulin/calnexin, conserved site | 242 - 254 | IPR018124-3 |
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell surface | The external part of the cell wall and/or plasma membrane. |
| cortical granule | A secretory vesicle that is stored under the cell membrane of an egg. These vesicles fuse with the egg plasma membrane as part of egg activation and are part of the block to polyspermy. |
| cytolytic granule | A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| sarcoplasmic reticulum lumen | The volume enclosed by the membranes of the sarcoplasmic reticulum. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| carbohydrate binding | Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. |
| unfolded protein binding | Binding to an unfolded protein. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
| protein stabilization | Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. |
| ubiquitin-dependent ERAD pathway | The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2TBR8 | CALR3 | Calreticulin-3 | Bos taurus (Bovine) | PR |
| P29413 | Calr | Calreticulin | Drosophila melanogaster (Fruit fly) | PR |
| Q96L12 | CALR3 | Calreticulin-3 | Homo sapiens (Human) | PR |
| P27797 | CALR | Calreticulin | Homo sapiens (Human) | PR |
| Q9D9Q6 | Calr3 | Calreticulin-3 | Mus musculus (Mouse) | PR |
| P14211 | Calr | Calreticulin | Mus musculus (Mouse) | PR |
| P28491 | CALR | Calreticulin | Sus scrofa (Pig) | PR |
| P18418 | Calr | Calreticulin | Rattus norvegicus (Rat) | PR |
| Q9SLY8 | CRO1 | Calreticulin | Oryza sativa subsp japonica (Rice) | PR |
| P27798 | crt-1 | Calreticulin | Caenorhabditis elegans | PR |
| Q7Z1E6 | crt | Calreticulin | Bombyx mori (Silk moth) | PR |
| Q38858 | CRT2 | Calreticulin-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O04153 | CRT3 | Calreticulin-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O04151 | CRT1 | Calreticulin-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLLPVPLLLG | LLGLAAADPT | VYFKEQFLDG | DGWTERWIES | KHKPDFGKFV | LSSGKFYGDQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EKDKGLQTSQ | DARFYALSAR | FEPFSNKGQT | LVVQFTVKHE | QNIDCGGGYV | KLFPAGLDQT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DMHGDSEYNI | MFGPDICGPG | TKKVHVIFNY | KGKNVLINKD | IRCKDDEFTH | LYTLIVRPNN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TYEVKIDNSQ | VESGSLEDDW | DFLPPKKIKD | PDAAKPEDWD | DRAKIDDPTD | SKPEDWDKPE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HIPDPDAKKP | EDWDEEMDGE | WEPPVIQNPE | YKGEWKPRQI | DNPEYKGIWI | HPEIDNPEYS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PDSNIYAYEN | FAVLGLDLWQ | VKSGTIFDNF | LITNDEAYAE | EFGNETWGVT | KAAEKQMKDK |
| 370 | 380 | 390 | 400 | 410 | |
| QDEEQRLHEE | EEEKKGKEEE | EADKDDDEDK | DEDEEDEDEK | EEEEEEDAAA | GQAKDEL |