AiPD: Autoinhibited Protein Database

Gene name	CRT2 (CRTL, At1g09210, T12M4.8)
Protein name	Calreticulin-2
Names
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT1G09210
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

333-424 (Predicted disordered autoinhibitory region) PR

333-424 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q38858-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_1_2976645_A_T	4	M>K	No	1000Genomes
tmp_1_2976639_G_A,T	6	P>H	No	1000Genomes
tmp_1_2976639_G_A,T	6	P>L	No	1000Genomes
tmp_1_2976613_C_G	15	G>R	No	1000Genomes
ENSVATH04543595	23	A>T	No	1000Genomes
tmp_1_2975710_C_T	83	E>K	No	1000Genomes
ENSVATH10830341	116	L>I	No	1000Genomes
tmp_1_2975574_T_C	128	D>G	No	1000Genomes
tmp_1_2975562_C_A	132	S>I	No	1000Genomes
ENSVATH13868836	157	N>Y	No	1000Genomes
ENSVATH01027167	184	T>S	No	1000Genomes
tmp_1_2975303_C_G	186	S>T	No	1000Genomes
tmp_1_2975013_T_C	225	Q>R	No	1000Genomes
tmp_1_2974969_C_T	240	D>N	No	1000Genomes
tmp_1_2974637_C_G	294	E>D	No	1000Genomes
ENSVATH00013219	309	L>I	No	1000Genomes
ENSVATH13868810	360	A>S	No	1000Genomes
ENSVATH04543564	361	A>G	No	1000Genomes
ENSVATH00013215	408	V>E	No	1000Genomes
tmp_1_2973361_T_C	410	S>G	No	1000Genomes
ENSVATH01027145	413	T>N	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Immunoglobulin subtype	568 - 652	IPR003599
domain	Immunoglobulin-like domain	562 - 650	IPR007110
domain	Immunoglobulin I-set	563 - 651	IPR013098

		Description
EC Number
Subcellular Localization	Endoplasmic reticulum lumen
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum lumen	The volume enclosed by the membranes of the endoplasmic reticulum.
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
plant-type vacuole	A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana.
secretory vesicle	A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space.

Name	Definition
calcium ion binding	Binding to a calcium ion (Ca2+).
carbohydrate binding	Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
unfolded protein binding	Binding to an unfolded protein.

Name	Definition
protein folding	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
response to endoplasmic reticulum stress	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
ubiquitin-dependent ERAD pathway	The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2TBR8	CALR3	Calreticulin-3	Bos taurus (Bovine)	PR
P52193	CALR	Calreticulin	Bos taurus (Bovine)	PR
P29413	Calr	Calreticulin	Drosophila melanogaster (Fruit fly)	PR
P27797	CALR	Calreticulin	Homo sapiens (Human)	PR
Q96L12	CALR3	Calreticulin-3	Homo sapiens (Human)	PR
P14211	Calr	Calreticulin	Mus musculus (Mouse)	PR
Q9D9Q6	Calr3	Calreticulin-3	Mus musculus (Mouse)	PR
P28491	CALR	Calreticulin	Sus scrofa (Pig)	PR
P18418	Calr	Calreticulin	Rattus norvegicus (Rat)	PR
Q9SLY8	CRO1	Calreticulin	Oryza sativa subsp japonica (Rice)	PR
P27798	crt-1	Calreticulin	Caenorhabditis elegans	PR
Q7Z1E6	crt	Calreticulin	Bombyx mori (Silk moth)	PR
O04151	CRT1	Calreticulin-1	Arabidopsis thaliana (Mouse-ear cress)	PR
O04153	CRT3	Calreticulin-3	Arabidopsis thaliana (Mouse-ear cress)	PR