P29413
Gene name |
Calr |
Protein name |
Calreticulin |
Names |
|
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG9429 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P29413
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P29413-F1 | Predicted | AlphaFoldDB |
No variants for P29413
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P29413 | |||||
No associated diseases with P29413
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| endomembrane system | A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. |
| endoplasmic reticulum lumen | The volume enclosed by the membranes of the endoplasmic reticulum. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| fusome | A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| carbohydrate binding | Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. |
| unfolded protein binding | Binding to an unfolded protein. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| olfactory behavior | The behavior of an organism in response to an odor. |
| protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
| sleep | Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain. |
| ubiquitin-dependent ERAD pathway | The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2TBR8 | CALR3 | Calreticulin-3 | Bos taurus (Bovine) | PR |
| P52193 | CALR | Calreticulin | Bos taurus (Bovine) | PR |
| P27797 | CALR | Calreticulin | Homo sapiens (Human) | PR |
| Q96L12 | CALR3 | Calreticulin-3 | Homo sapiens (Human) | PR |
| P14211 | Calr | Calreticulin | Mus musculus (Mouse) | PR |
| Q9D9Q6 | Calr3 | Calreticulin-3 | Mus musculus (Mouse) | PR |
| P28491 | CALR | Calreticulin | Sus scrofa (Pig) | PR |
| P18418 | Calr | Calreticulin | Rattus norvegicus (Rat) | PR |
| Q9SLY8 | CRO1 | Calreticulin | Oryza sativa subsp japonica (Rice) | PR |
| P27798 | crt-1 | Calreticulin | Caenorhabditis elegans | PR |
| Q7Z1E6 | crt | Calreticulin | Bombyx mori (Silk moth) | PR |
| Q38858 | CRT2 | Calreticulin-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O04151 | CRT1 | Calreticulin-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O04153 | CRT3 | Calreticulin-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMWCKTVIVL | LATVGFISAE | VYLKENFDNE | NWEDTWIYSK | HPGKEFGKFV | LTPGTFYNDA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EADKGIQTSQ | DARFYAASRK | FDGFSNEDKP | LVVQFSVKHE | QNIDCGGGYV | KLFDCSLDQT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DMHGESPYEI | MFGPDICGPG | TKKVHVIFSY | KGKNHLISKD | IRCKDDVYTH | FYTLIVRPDN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TYEVLIDNEK | VESGNLEDDW | DFLAPKKIKD | PTATKPEDWD | DRATIPDPDD | KKPEDWDKPE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HIPDPDATKP | EDWDDEMDGE | WEPPMIDNPE | FKGEWQPKQL | DNPNYKGAWE | HPEIANPEYV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PDDKLYLRKE | ICTLGFDLWQ | VKSGTIFDNV | LITDDVELAA | KAAAEVKNTQ | AGEKKMKEAQ |
| 370 | 380 | 390 | 400 | ||
| DEVQRKKDEE | EAKKASDKDD | EDEDDDDEEK | DDESKQDKDQ | SEHDEL |