O04151
PR
Gene name |
CRT1 (At1g56340, F13N6.20, F14G9.5) |
Protein name |
Calreticulin-1 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G56340 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O04151
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O04151-F1 | Predicted | AlphaFoldDB |
22 variants for O04151
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH04976763 | 7 | K>N | No | 1000Genomes | |
| ENSVATH00100862 | 31 | E>D | No | 1000Genomes | |
| tmp_1_21092127_C_A | 36 | K>N | No | 1000Genomes | |
| tmp_1_21092090_T_A | 49 | T>S | No | 1000Genomes | |
| tmp_1_21091953_T_A | 70 | Q>H | No | 1000Genomes | |
| ENSVATH01378840 | 74 | D>N | No | 1000Genomes | |
| ENSVATH00100859 | 118 | D>E | No | 1000Genomes | |
| tmp_1_21091609_T_G | 160 | I>L | No | 1000Genomes | |
| ENSVATH00100858 | 160 | I>S | No | 1000Genomes | |
| tmp_1_21091516_T_C | 191 | N>D | No | 1000Genomes | |
| tmp_1_21091465_C_G | 208 | A>P | No | 1000Genomes | |
| tmp_1_21091183_C_G | 274 | E>D | No | 1000Genomes | |
| ENSVATH04976723 | 283 | K>N | No | 1000Genomes | |
| ENSVATH13594719 | 337 | S>T | No | 1000Genomes | |
| ENSVATH13594717 | 353 | K>M | No | 1000Genomes | |
| tmp_1_21090628_C_G,A | 353 | K>N | No | 1000Genomes | |
| tmp_1_21090390_C_A | 375 | K>N | No | 1000Genomes | |
| tmp_1_21090385_G_A | 377 | A>V | No | 1000Genomes | |
| tmp_1_21090198_C_T | 411 | E>K | No | 1000Genomes | |
| tmp_1_21090174_C_A | 419 | D>Y | No | 1000Genomes | |
| tmp_1_21090167_G_C | 421 | A>G | No | 1000Genomes | |
| ENSVATH13594690 | 421 | A>S | No | 1000Genomes |
No associated diseases with O04151
3 regional properties for O04151
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Calreticulin/calnexin, conserved site | 101 - 116 | IPR018124-1 |
| conserved_site | Calreticulin/calnexin, conserved site | 133 - 141 | IPR018124-2 |
| conserved_site | Calreticulin/calnexin, conserved site | 246 - 258 | IPR018124-3 |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum lumen | The volume enclosed by the membranes of the endoplasmic reticulum. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plant-type vacuole | A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana. |
| plasmodesma | A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell. |
| secretory vesicle | A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| carbohydrate binding | Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. |
| unfolded protein binding | Binding to an unfolded protein. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
| response to endoplasmic reticulum stress | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. |
| ubiquitin-dependent ERAD pathway | The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2TBR8 | CALR3 | Calreticulin-3 | Bos taurus (Bovine) | PR |
| P52193 | CALR | Calreticulin | Bos taurus (Bovine) | PR |
| P29413 | Calr | Calreticulin | Drosophila melanogaster (Fruit fly) | PR |
| P27797 | CALR | Calreticulin | Homo sapiens (Human) | PR |
| Q96L12 | CALR3 | Calreticulin-3 | Homo sapiens (Human) | PR |
| P14211 | Calr | Calreticulin | Mus musculus (Mouse) | PR |
| Q9D9Q6 | Calr3 | Calreticulin-3 | Mus musculus (Mouse) | PR |
| P28491 | CALR | Calreticulin | Sus scrofa (Pig) | PR |
| P18418 | Calr | Calreticulin | Rattus norvegicus (Rat) | PR |
| Q9SLY8 | CRO1 | Calreticulin | Oryza sativa subsp japonica (Rice) | PR |
| P27798 | crt-1 | Calreticulin | Caenorhabditis elegans | PR |
| Q7Z1E6 | crt | Calreticulin | Bombyx mori (Silk moth) | PR |
| O04153 | CRT3 | Calreticulin-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38858 | CRT2 | Calreticulin-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAKLNPKFIS | LILFALVVIV | SAEVIFEEKF | EDGWEKRWVK | SDWKKDDNTA | GEWKHTAGNW |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SGDANDKGIQ | TSEDYRFYAI | SAEFPEFSNK | DKTLVFQFSV | KHEQKLDCGG | GYMKLLSDDV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DQTKFGGDTP | YSIMFGPDIC | GYSTKKVHAI | LTYNGTNHLI | KKEVPCETDQ | LTHVYTFVLR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PDATYSILID | NVEKQTGSLY | SDWDLLPAKK | IKDPSAKKPE | DWDDKEYIPD | PEDTKPAGYD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DIPKEIPDTD | AKKPEDWDDE | EDGEWTAPTI | PNPEYNGEWK | PKKIKNPAYK | GKWKAPMIDN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PEFKDDPELY | VFPKLKYVGV | ELWQVKSGSL | FDNVLVSDDP | EYAKKLAEET | WGKHKDAEKA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AFDEAEKKRE | EEESKDAPAE | SDAEEEAEDD | DNEGDDSDNE | SKSEETKEAE | ETKEAEETDA |
| AHDEL |