AiPD: Autoinhibited Protein Database

P27824

Gene name	CANX
Protein name	Calnexin
Names	IP90, Major histocompatibility complex class I antigen-binding protein p88, p90
Species	Homo sapiens (Human)
KEGG Pathway	hsa:821
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

521-592 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

521-592 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for P27824

Entry ID	Method	Resolution	Chain	Position	Source
AF-P27824-F1	Predicted				AlphaFoldDB

397 variants for P27824

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs200510202 CA3598209	2	E>K		No	ClinGen ExAC TOPMed
rs776034798 CA3598210	3	G>A		No	ExAC TOPMed gnomAD ClinGen
CA362443052 rs1436918966	3	G>R		No	TOPMed ClinGen
rs776034798 CA133098244	3	G>V		No	ClinGen ExAC TOPMed gnomAD
CA362443084 rs1174029586	4	K>N		No	gnomAD ClinGen
CA362443078 rs1481345816	4	K>R		No	gnomAD ClinGen
rs761316605 CA3598211	5	W>*		No	ExAC gnomAD ClinGen
COSM1066679 CA362443111 rs1454098604	6	L>S	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
CA362443127 rs1290306845	7	L>P		No	ClinGen gnomAD
rs551656982 CA3598212	8	C>F		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA362443141 rs551656982	8	C>S		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA362443139 rs551656982	8	C>Y		No	1000Genomes ExAC TOPMed gnomAD ClinGen
rs1323578074 CA362443155	9	M>V		No	TOPMed gnomAD ClinGen
CA3598213 CA3598214 rs750129275	12	V>L		No	ClinGen ExAC TOPMed gnomAD
CA362443201 rs750129275	12	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1030608231 CA133098319	13	L>F		No	Ensembl ClinGen
CA3598216 rs753040389	15	T>A		No	ExAC gnomAD ClinGen
CA3598217 rs756604999	17	I>V		No	ClinGen ExAC TOPMed
CA3598219 COSM2151341 rs753869333	20	A>T	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA362443307 rs1204646574	21	H>R		No	ClinGen gnomAD
rs779124132 CA362443313	22	D>G		No	ClinGen ExAC TOPMed gnomAD
rs779124132 CA3598221	22	D>V		No	ClinGen ExAC TOPMed gnomAD
CA3598220 rs757304942	22	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs144777925 CA3598222	24	H>Y		No	ClinGen ESP ExAC gnomAD
rs961708620 CA133098358	25	D>V		No	TOPMed gnomAD ClinGen
TCGA novel	27	D>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1581849658 CA362443397	28	V>A		No	ClinGen Ensembl
CA133098359 rs773718862	28	V>L		No	TOPMed gnomAD ClinGen
CA362443390 rs773718862	28	V>M		No	ClinGen TOPMed gnomAD
CA3598223 rs146806845	29	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs980114112 CA133098364	31	I>V		No	Ensembl ClinGen
rs768479664 CA3598226	32	E>D		No	ClinGen ExAC gnomAD
CA3598225 rs746759221	32	E>Q		No	ExAC gnomAD ClinGen
CA362443481 rs1366842266	34	D>H		No	gnomAD ClinGen
CA3598227 rs148961304 COSM1066681	37	D>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ESP ExAC TOPMed gnomAD ClinGen cosmic curated NCI-TCGA
CA362443545 rs1230313556	38	V>A		No	TOPMed ClinGen
rs761639685 CA133098400	39	I>L		No	ClinGen ExAC TOPMed gnomAD
rs769409264 CA3598229	39	I>T		No	ClinGen ExAC gnomAD
rs761639685 CA3598228	39	I>V		No	ExAC TOPMed gnomAD ClinGen
CA362443645 rs1216565124	44	D>Y		No	gnomAD ClinGen
TCGA novel	45	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3598231 rs762646334	48	D>E		No	ClinGen ExAC
rs1292746299 CA362443715	48	D>V		No	gnomAD ClinGen
TCGA novel	49	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1220343895 CA362443751	50	T>A		No	gnomAD ClinGen
CA133098436 rs1057284737	50	T>S		No	Ensembl ClinGen
rs1220343895 CA362443748	50	T>S		No	gnomAD ClinGen
CA3598233 rs775866282	52	P>L		No	ExAC gnomAD ClinGen
rs918786337 CA133098463	52	P>S		No	Ensembl ClinGen
TCGA novel	52	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3598234 rs761034514	53	P>S		No	ExAC ClinGen
CA133098482 rs929069704	54	S>L		No	ClinGen Ensembl
rs1047432279 CA133098485	55	S>T		No	Ensembl ClinGen
rs764524851 CA3598235	56	P>S		No	ClinGen ExAC gnomAD
CA3598249 rs376343417	61	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1206480222 CA362444323	64	V>I		No	ClinGen TOPMed gnomAD
rs1206480222 CA362444318	64	V>L		No	ClinGen TOPMed gnomAD
CA362444336 rs1249521943	65	P>A		No	ClinGen gnomAD
CA133098899 rs992851702	65	P>L		No	ClinGen gnomAD
CA362444346 rs1388509469	66	T>A		No	ClinGen TOPMed
CA3598250 rs773937151	67	G>E		No	ExAC ClinGen
rs867506993 CA133098934	68	E>K		No	ClinGen Ensembl
rs544838582 CA3598252	72	A>V		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA3598253 rs776837383	73	D>N		No	ClinGen ExAC gnomAD
CA3598254 rs762405151	74	S>C		No	ExAC gnomAD ClinGen
CA362444473 rs1182453105	74	S>P		No	gnomAD ClinGen
rs1429746963 CA362444530	77	R>G		No	gnomAD ClinGen
CA3598255 rs765797003	78	G>E		No	ExAC TOPMed gnomAD ClinGen
CA3598258 rs766551548	81	S>A		No	ClinGen ExAC TOPMed gnomAD
CA362444724 rs1562473876	84	I>V		No	ClinGen Ensembl
CA133099674 rs997403805	87	K>N		No	ClinGen gnomAD
CA3598271 rs547055719	87	K>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1252347167 CA362444789	88	A>T		No	ClinGen TOPMed
rs1453086043 CA362444821	90	K>E		No	ClinGen gnomAD
rs1255080613 CA362444867	92	D>G		No	ClinGen TOPMed
CA362444855 rs1339766611	92	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	TOPMed gnomAD ClinGen NCI-TCGA
rs763547100 CA3598274	94	D>G		No	ExAC gnomAD ClinGen
CA3598273 rs368902277	94	D>N		No	ESP ExAC TOPMed gnomAD ClinGen
rs987279848 CA133099735	95	D>H		No	ClinGen TOPMed
rs867331488 CA133099743	98	A>V		No	ClinGen Ensembl
rs1224066167 CA362446393	103	K>N		No	gnomAD ClinGen
rs763601463 CA3598292	105	E>G		No	ClinGen ExAC gnomAD
CA362446490 rs1450333440	107	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	gnomAD ClinGen NCI-TCGA
rs531497541 CA3598293	110	K>R		No	ClinGen ExAC TOPMed gnomAD
rs774523334 CA3598294	111	E>A		No	ExAC gnomAD ClinGen
rs1581856329 CA362446619	111	E>K		No	ClinGen Ensembl
CA362446685 rs1581856354	112	S>L		No	ClinGen Ensembl
rs767797862 CA3598296	113	K>N		No	ClinGen ExAC gnomAD
CA362446701 rs1175755473	113	K>Q		No	ClinGen gnomAD
CA362446757 rs1425441266	116	G>S		No	ClinGen gnomAD
TCGA novel	119	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3598298 rs760882703	123	M>K		No	ExAC gnomAD ClinGen
rs763918161 CA3598299	125	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA362447016 rs1329319100	125	R>W		No	gnomAD ClinGen
CA362447067 rs1562477210	127	K>M		No	ClinGen Ensembl
CA3598300 rs753609572	128	H>Y		No	ClinGen ExAC gnomAD
TCGA novel	129	H>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1384938731 CA362447150	130	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	132	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1383056902 CA362447241	133	A>T		No	ClinGen gnomAD
rs1364804402 CA362447271	133	A>V		No	ClinGen TOPMed
rs778647017 CA3598302	134	K>E		No	ExAC gnomAD ClinGen
rs767277435 CA3598303	136	N>S		No	ClinGen ExAC gnomAD
CA3598305 rs79378421	140	L>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA133100724 rs1031288128	140	L>P		No	TOPMed gnomAD ClinGen
CA362447481 rs1031288128	140	L>Q		No	ClinGen TOPMed gnomAD
CA362447500 rs1208660807	141	F>S		No	ClinGen gnomAD
rs1013113374 CA133100742	144	K>T		No	ClinGen Ensembl
rs1439982711 CA362447691	148	V>F		No	ClinGen gnomAD
rs1409462926 CA362448059	153	N>S		No	TOPMed ClinGen
rs1420228343 CA362448120	156	N>S		No	TOPMed ClinGen
CA3598325 rs377451496	157	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA3598326 rs780927363	158	I>L		No	ExAC gnomAD ClinGen
rs889578700 CA133101373	158	I>R		No	Ensembl ClinGen
rs1382308411 CA362448300	164	Y>C		No	ClinGen gnomAD
CA362448324 rs1319639074	165	V>G		No	gnomAD ClinGen
TCGA novel	166	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779331457 CA3598329	169	S>C		No	ExAC ClinGen
CA3598331 rs772612377	170	K>E		No	ClinGen ExAC gnomAD
CA362448496 rs1324764556	173	E>D		No	ClinGen gnomAD
rs775569975 CA3598332	173	E>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC gnomAD ClinGen NCI-TCGA
CA3598333 rs747023297	174	L>F		No	ExAC gnomAD ClinGen
CA362448501 rs747023297	174	L>I		No	ClinGen ExAC gnomAD
rs143726426 CA3598334	174	L>P		No	ESP ExAC TOPMed gnomAD ClinGen
rs143726426 CA133101414	174	L>R		No	ESP ExAC TOPMed gnomAD ClinGen
TCGA novel	177	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1215986273 CA362449624	178	Q>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA3598349 rs758832045	179	F>L		No	ExAC gnomAD ClinGen
rs780479093 CA3598350	180	H>R		No	ClinGen ExAC TOPMed gnomAD
CA133102323 rs904374755	181	D>E		No	TOPMed gnomAD ClinGen
rs1183586805 CA362449812	184	P>A		No	ClinGen gnomAD
rs1040946377 CA133102356	185	Y>F		No	Ensembl ClinGen
CA3598354 rs748363222	186	T>M		No	ClinGen ExAC gnomAD
rs1366740689 CA362449986	191	P>T		No	gnomAD ClinGen
rs1562480957 CA362450055	193	K>R		No	ClinGen Ensembl
CA133102376 rs1031621798	194	C>W		No	TOPMed ClinGen
TCGA novel	195	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3598356 rs772909275	197	D>E		No	ClinGen ExAC gnomAD
CA3598357 rs762744899	198	Y>C		No	ClinGen ExAC gnomAD
CA3598358 rs771008892	199	K>E		No	ExAC gnomAD ClinGen
rs1581860511 CA362450262	201	H>R		No	Ensembl ClinGen
rs767177938 CA362450392	204	F>L		No	ExAC TOPMed gnomAD ClinGen
CA3598362 rs752230231	205	R>*		No	ExAC gnomAD ClinGen
rs1315765352 CA362450416	205	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	gnomAD ClinGen NCI-TCGA
CA362450446 rs1291386793	206	H>R		No	ClinGen TOPMed
rs141861672 CA3598365	207	K>E		No	ClinGen ESP ExAC gnomAD
rs150270438 CA3598366	207	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs780392943 CA3598367	208	N>S		No	ClinGen ExAC gnomAD
CA3598368 rs752100105	210	K>Q		No	ExAC TOPMed gnomAD ClinGen
rs1450630294 CA362450550	210	K>R		No	ClinGen gnomAD
rs755452646 CA362450570	211	T>K		No	ClinGen ExAC TOPMed gnomAD
rs755452646 COSM268836 CA133102434	211	T>M	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen cosmic curated NCI-TCGA
rs755452646 CA3598369	211	T>R		No	ExAC TOPMed gnomAD ClinGen
rs781268361 CA3598370	212	G>A		No	ExAC gnomAD ClinGen
CA362450580 rs948199686	212	G>C		No	TOPMed gnomAD ClinGen
rs781268361 CA3598371	212	G>D		No	ExAC gnomAD ClinGen
rs948199686 CA133102444	212	G>S		No	ClinGen TOPMed gnomAD
rs769909544 CA3598372	214	Y>C		No	ExAC TOPMed gnomAD ClinGen
CA362450655 rs1462873207	215	E>D		No	gnomAD ClinGen
TCGA novel	218	H>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA133102528 rs1003507982	218	H>R		No	Ensembl ClinGen
CA362450756 rs1398407877	220	K>M		No	gnomAD ClinGen
rs777997443 CA362450809	223	D>H		No	ClinGen ExAC gnomAD
CA3598373 rs777997443	223	D>N		No	ExAC gnomAD ClinGen
CA133102538 rs1015102398	224	A>G		No	ClinGen Ensembl
rs207466646 CA133102541	225	D>Y		No	ClinGen Ensembl
TCGA novel	226	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3598374 rs749461583	226	L>V		No	ExAC gnomAD ClinGen
CA3598375 rs770921171	228	T>I		No	ClinGen ExAC gnomAD
rs1312004454 CA362451072	233	K>E		No	ClinGen gnomAD
rs1229358068 CA362451110	234	K>R		No	gnomAD ClinGen
CA3598427 rs761267434	244	P>T		No	ExAC gnomAD ClinGen
rs1219967178 CA362453533	245	D>N		No	ClinGen TOPMed
rs764469757 CA3598428	249	E>V		No	ClinGen ExAC gnomAD
rs753972476 CA3598429	255	S>Y		No	ClinGen ExAC TOPMed gnomAD
CA362453739 rs1237790098	258	N>S		No	ClinGen gnomAD
CA3598432 rs750712444	259	S>N		No	ClinGen ExAC TOPMed gnomAD
CA3598431 rs765401038	259	S>R		No	ExAC gnomAD ClinGen
rs758525989 CA3598433	259	S>R		No	ClinGen ExAC TOPMed gnomAD
CA362453769 rs750712444	259	S>T		No	ClinGen ExAC TOPMed gnomAD
CA362453829 rs1401160238	262	L>M		No	TOPMed ClinGen
CA133112325 rs961067950	266	M>I		No	ClinGen TOPMed
CA362453914 rs1171164764	266	M>V		No	ClinGen TOPMed gnomAD
rs965188301 CA133112329	267	T>S		No	ClinGen Ensembl
CA362454031 rs1463846811	269	P>L		No	ClinGen TOPMed gnomAD
CA3598434 rs573991716	269	P>S		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	269	P>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1562496714 CA362454097	271	N>S		No	Ensembl ClinGen
CA3598435 rs143170114	273	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA3598436 rs754945089	274	R>C		No	ClinGen ExAC TOPMed gnomAD
rs970217783 COSM1543554 CA133112338	274	R>H	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs970217783 CA362454157	274	R>L		No	TOPMed gnomAD ClinGen
CA362454220 rs1339245777	276	I>L		No	ClinGen gnomAD
CA133112344 rs935452629	277	E>G		No	ClinGen TOPMed
CA3598439 rs769363661	279	P>L		No	ExAC TOPMed gnomAD ClinGen
rs1342844362 CA362454383	280	E>A		No	ClinGen gnomAD
rs1217180939 CA362454393	280	E>D		No	ClinGen gnomAD
CA362454382 rs1279368061	280	E>K		No	ClinGen gnomAD
CA362454414 rs1257673448	281	D>N		No	gnomAD ClinGen
CA3598441 rs748992336	282	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA3598440 rs777237586	282	R>W		No	ExAC TOPMed gnomAD ClinGen
CA133112361 rs553234403 COSM1066683	285	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes NCI-TCGA TOPMed
CA3598445 rs769221257	290	R>I		No	ExAC gnomAD ClinGen
rs770456727 CA133112369	292	K>E		No	Ensembl ClinGen
rs1256933838 CA362454796	293	I>L		No	ClinGen TOPMed
TCGA novel	293	I>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362454868 rs1377855011	294	P>L		No	gnomAD ClinGen
CA133112375 rs901153010	295	D>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA3598449 rs750481212	298	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
rs763262566 CA3598450	298	A>V		No	ExAC gnomAD ClinGen
CA3598452 rs751380083	299	V>A		No	ClinGen ExAC TOPMed gnomAD
rs766441669 CA3598451	299	V>L		No	ExAC gnomAD ClinGen
rs780963402 CA3598454	300	K>R		No	ExAC gnomAD ClinGen
rs756081134 CA3598474	305	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	306	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1015978938 CA133113597	307	D>V		No	ClinGen Ensembl
rs1438518619 CA362456286	310	A>G		No	gnomAD ClinGen
rs778453311 CA3598478	311	K>E		No	ExAC gnomAD ClinGen
TCGA novel	314	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1291175824 CA362456396	315	E>K		No	TOPMed ClinGen
rs745553209 CA3598479	316	E>G		No	ExAC TOPMed gnomAD ClinGen
TCGA novel	317	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA133113619 rs1028893049	318	T>A		No	ClinGen Ensembl
TCGA novel	318	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	320	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs140056120 CA3598481	321	E>K		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
CA362456603 rs1398453182	322	G>D		No	ClinGen TOPMed
rs748457502 CA3598482	327	E>D		No	ClinGen ExAC gnomAD
CA133113629 rs987293060	328	P>A		No	ClinGen Ensembl
CA362456832 rs1390890761	331	V>E		No	ClinGen gnomAD
CA3598484 rs557592892	331	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1313354040 CA362456870	333	D>V		No	ClinGen gnomAD
CA3598485 rs143596594	334	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA133113635 rs779436099	335	D>G		No	TOPMed ClinGen
CA133113637 rs764247531	336	A>T		No	ClinGen gnomAD
CA362456922 rs1318298193	336	A>V		No	ClinGen gnomAD
rs1562504500 CA362456952	338	K>T		No	Ensembl ClinGen
rs890647782 CA133113648	341	D>Y		No	TOPMed ClinGen
rs551597848 CA133113812	343	D>N		No	ClinGen Ensembl
CA3598519 rs761684718	345	D>A		No	ClinGen ExAC gnomAD
rs765151089 CA3598520	345	D>E		No	ClinGen ExAC gnomAD
rs1451533282 CA362457202	345	D>N		No	TOPMed ClinGen
CA3598521 rs749914552	348	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1312272162 CA362457299	350	W>R		No	gnomAD ClinGen
CA3598524 rs765982240	351	E>A		No	ClinGen ExAC TOPMed gnomAD
rs1227565725 CA362457346	352	A>P		No	TOPMed gnomAD ClinGen
rs1274228025 CA362457363	353	P>S		No	ClinGen TOPMed
rs754657559 CA3598526	355	I>V		No	ExAC gnomAD ClinGen
rs1581889808 COSM1672179 CA362457531	359	R>K	haematopoietic_and_lymphoid_tissue [Cosmic]	No	Ensembl ClinGen cosmic curated
CA3598527 rs778023419	363	A>T		No	ClinGen ExAC gnomAD
rs920342866 CA133113822	364	P>S		No	ClinGen TOPMed gnomAD
CA3598529 rs199941318	368	V>I		No	ExAC TOPMed gnomAD ClinGen
rs779422274 CA3598530	371	R>Q		No	ExAC TOPMed gnomAD ClinGen
rs746365417 CA3598531	372	P>T		No	ClinGen ExAC gnomAD
TCGA novel	373	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772209604 CA3598532	373	V>M		No	ExAC gnomAD ClinGen
CA362457896 rs1330434566	374	I>T		No	ClinGen TOPMed
CA3598534 rs747252071	377	P>L		No	ExAC gnomAD ClinGen
rs556166734 CA3598536	385	P>L		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA362458311 rs1431514907	385	P>T		No	gnomAD ClinGen
rs1307082089 CA362458390	387	M>I		No	TOPMed ClinGen
rs1380866746 CA362458354	387	M>V		No	gnomAD ClinGen
rs761606840 CA3598537	389	D>V		No	ClinGen ExAC
TCGA novel	391	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3598538 rs769462879	391	P>R		No	ExAC gnomAD ClinGen
CA3598541 rs762950869	392	S>I		No	ClinGen ExAC TOPMed gnomAD
CA3598540 rs762950869	392	S>N		No	ExAC TOPMed gnomAD ClinGen
CA3598567 rs765641166	399	P>A		No	ExAC TOPMed gnomAD ClinGen
CA362459787 rs1292417898	402	I>M		No	gnomAD ClinGen
rs187644199 CA3598568	402	I>T		No	ClinGen 1000Genomes ExAC
CA3598569 rs373500447	403	P>S		No	ClinGen ESP ExAC gnomAD
rs1224355088 CA362459921	411	L>V		No	TOPMed ClinGen
rs766809881 CA3598570	412	E>A		No	ExAC gnomAD ClinGen
CA3598571 rs751992765	413	P>A		No	ExAC TOPMed gnomAD ClinGen
TCGA novel	415	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs149513016 CA3598572	415	R>I		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	415	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	416	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs370228321 CA133114448	417	T>A		No	Ensembl ClinGen
TCGA novel	420	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs144513282 CA3598574	422	I>L		No	ESP ExAC TOPMed gnomAD ClinGen
rs144513282 CA3598573	422	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs148399587 CA3598577	432	D>Y		No	ESP ExAC TOPMed gnomAD ClinGen
TCGA novel	435	F>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760711956	435	F>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs555626485 CA3598579	439	I>V		No	1000Genomes ExAC TOPMed gnomAD ClinGen
rs1327542299 CA362460759	442	A>P		No	ClinGen gnomAD
CA362460768 rs1327542299	442	A>S		No	ClinGen gnomAD
rs774489318 CA3598580	443	D>N		No	ExAC gnomAD ClinGen
CA3598581 rs369795296	444	R>G		No	ESP ExAC gnomAD ClinGen
rs771656553 CA362460852	444	R>L		No	ExAC TOPMed gnomAD ClinGen
rs771656553 CA3598582	444	R>Q		No	ExAC TOPMed gnomAD ClinGen
rs1354013828 CA362460920	446	I>V		No	ClinGen TOPMed gnomAD
CA362460974 rs1175007698	447	V>A		No	ClinGen TOPMed
CA362461016 rs1233048370	448	D>G		No	gnomAD ClinGen
CA362461117 rs868822397	451	A>S		No	ClinGen Ensembl
rs868822397 CA133114468	451	A>T		No	ClinGen Ensembl
CA3598583 rs373402263	452	N>S		No	ExAC TOPMed gnomAD ClinGen
CA362461196 rs1562512599	453	D>G		No	Ensembl ClinGen
CA362461298 rs763666522	456	G>D		No	ClinGen ExAC gnomAD
CA3598584 rs760400717	456	G>R		No	ClinGen ExAC gnomAD
rs763666522 CA3598585	456	G>V		No	ExAC gnomAD ClinGen
CA3598588 rs766725772	458	K>R		No	ClinGen ExAC TOPMed gnomAD
CA3598589 rs780711642	459	K>R		No	ExAC TOPMed gnomAD ClinGen
rs146501349 CA3598591	460	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs756411854 CA3598593	462	D>G		No	ExAC gnomAD ClinGen
CA3598595 rs749509239	463	G>E		No	ExAC gnomAD ClinGen
rs757188323 CA3598596	464	A>S		No	ClinGen ExAC TOPMed gnomAD
rs980024048 CA133114496	466	E>K		No	ClinGen TOPMed
rs1189288785 CA362462089	467	P>S		No	ClinGen TOPMed
CA3598621 rs200863515	469	V>F		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs200863515 CA3598620	469	V>I		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs1216727865 CA362462134	470	V>L		No	ClinGen TOPMed
rs1251891791 CA362462150 CA362462146	471	G>R		No	TOPMed gnomAD ClinGen
rs1251891791 CA362462144	471	G>W		No	TOPMed gnomAD ClinGen
TCGA novel	473	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362462225 rs1439762260	473	M>V		No	gnomAD ClinGen
TCGA novel	480	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	480	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	480	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3598625 rs772471618	481	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1447603878 CA362463376	484	W>C		No	gnomAD ClinGen
rs1581897606 CA362463395	485	V>G		No	Ensembl ClinGen
CA3598628 rs374190394	485	V>I		No	ESP ExAC TOPMed gnomAD ClinGen
CA362463387 rs374190394	485	V>L		No	ESP ExAC TOPMed gnomAD ClinGen
rs1333848216 CA362463422	487	Y>C		No	TOPMed gnomAD ClinGen
CA362463444 rs1265768030	488	I>V		No	ClinGen gnomAD
CA133114734 rs1045386501	495	V>A		No	TOPMed ClinGen
TCGA novel	495	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765315948 CA362463767	498	V>F		No	ExAC TOPMed gnomAD ClinGen
CA3598632 rs765315948	498	V>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	499	I>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362463805 rs1179911015	500	L>F		No	ClinGen gnomAD
rs1253316991 CA362463807	500	L>P		No	gnomAD ClinGen
rs1181681807 CA362463857	503	C>R		No	ClinGen gnomAD
CA3598633 rs750641770	503	C>Y		No	ExAC gnomAD ClinGen
rs758190011 CA3598634	504	S>C		No	ExAC gnomAD ClinGen
TCGA novel	507	K>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA133115047 rs992257090 COSM1066684	508	Q>H	endometrium [Cosmic]	No	TOPMed gnomAD ClinGen cosmic curated
CA3598657 rs773343126	509	T>I		No	ClinGen ExAC gnomAD
CA3598659 rs367668742	510	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs367668742 CA3598658	510	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA362464251 rs1286008358	511	G>D		No	TOPMed ClinGen
CA3598660 rs751313954	512	M>I		No	ExAC gnomAD ClinGen
CA362464272 rs1241484135	512	M>T		No	TOPMed ClinGen
rs754912290 CA3598661	513	E>D		No	ExAC gnomAD ClinGen
rs1356395183 CA362464333	516	K>*		No	ClinGen TOPMed
rs1282791849 CA362464401	520	P>A		No	ClinGen TOPMed
TCGA novel	520	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3598663 rs371798319	522	P>L		No	ESP ExAC TOPMed gnomAD ClinGen
rs559928822 CA3598665	524	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs748945692 CA362464531	525	K>N		No	ExAC TOPMed gnomAD ClinGen
CA362464557 rs1188578368	527	E>K		No	TOPMed gnomAD ClinGen
rs1176825225 CA362464635	530	E>G		No	gnomAD ClinGen
rs756889602 CA3598669	531	K>M		No	ExAC gnomAD ClinGen
rs747313211 CA3598671	537	K>R		No	ClinGen ExAC TOPMed
rs75423033 CA3598673	540	E>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs75423033 CA133115083	540	E>V		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
CA3598674 rs777341153	542	E>Q		No	ExAC gnomAD ClinGen
TCGA novel	543	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776143295 CA133115088	544	G>E		No	Ensembl ClinGen
rs1286758264 CA362464918	545	E>K		No	ClinGen gnomAD
rs146720093 CA3598676	546	E>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ESP ExAC TOPMed gnomAD ClinGen NCI-TCGA
CA3598675 rs143348712	546	E>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1562517599 CA362464927	546	E>Q		No	ClinGen Ensembl
CA3598677 rs773293232	548	L>F		No	ExAC gnomAD ClinGen
CA362464942 rs1232802393	548	L>R		No	ClinGen gnomAD
CA133115804 rs1022633432	549	E>V		No	TOPMed gnomAD ClinGen
CA133115811 rs111809764	551	K>*		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
CA3598701 rs111809764	551	K>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3598702 rs770986913	552	Q>H		No	ExAC gnomAD ClinGen
CA362465899 rs1471097383	553	K>R		No	gnomAD ClinGen
CA3598703 rs774623024	554	S>N		No	ClinGen ExAC gnomAD
rs771905020 CA362466139	558	E>D		No	ExAC gnomAD ClinGen
rs759725745 CA3598704	558	E>K		No	ClinGen ExAC gnomAD
rs1391758354 CA362466216	560	G>D		No	gnomAD ClinGen
rs200395157 CA3598706	560	G>S		No	ESP ExAC TOPMed gnomAD ClinGen
CA3598707 rs760563367	562	T>I		No	ClinGen ExAC gnomAD
rs1331388035 CA362466349	564	S>I		No	gnomAD ClinGen
CA362466407 rs1400362809	566	E>Q		No	ClinGen TOPMed
rs1474263495 CA362466435	567	E>A		No	TOPMed ClinGen
CA133115832 rs1031643847	567	E>K		No	TOPMed gnomAD ClinGen
CA362466463 rs1278285093	568	E>K		No	gnomAD ClinGen
CA3598709 rs764030651	571	K>R		No	ExAC gnomAD ClinGen
CA362466645 rs1299836705	574	A>T		No	gnomAD ClinGen
CA362467669 rs1485217155	576	E>D		No	gnomAD ClinGen
rs1193544423 CA362467671	577	D>N		No	ClinGen gnomAD
CA362467773 rs1243418716	582	R>I		No	ClinGen gnomAD
CA362467777 rs761816122	582	R>S		No	ClinGen ExAC TOPMed gnomAD
rs928704900 CA133116618	583	S>*		No	ClinGen Ensembl
rs772663643 CA133116622	584	P>L		No	ClinGen Ensembl
TCGA novel	585	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362467829 rs1390131983	587	R>G		No	ClinGen gnomAD
rs1176053647 CA362467858	589	P>T		No	gnomAD ClinGen
CA362467870 rs1374085607	590	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1414545674 CA362467873	590	R>Q		No	gnomAD ClinGen
CA133116629 rs972796544	593	E>S		No	ClinGen Ensembl

No associated diseases with P27824

14 regional properties for P27824

Type	Name	Position	InterPro Accession
repeat	HAT (Half-A-TPR) repeat	56 - 88	IPR003107-1
repeat	HAT (Half-A-TPR) repeat	90 - 122	IPR003107-2
repeat	HAT (Half-A-TPR) repeat	124 - 156	IPR003107-3
repeat	HAT (Half-A-TPR) repeat	158 - 189	IPR003107-4
repeat	HAT (Half-A-TPR) repeat	191 - 222	IPR003107-5
repeat	HAT (Half-A-TPR) repeat	224 - 259	IPR003107-6
repeat	HAT (Half-A-TPR) repeat	261 - 295	IPR003107-7
repeat	HAT (Half-A-TPR) repeat	339 - 373	IPR003107-8
repeat	HAT (Half-A-TPR) repeat	383 - 419	IPR003107-9
repeat	HAT (Half-A-TPR) repeat	421 - 452	IPR003107-10
repeat	HAT (Half-A-TPR) repeat	454 - 486	IPR003107-11
repeat	HAT (Half-A-TPR) repeat	488 - 522	IPR003107-12
repeat	HAT (Half-A-TPR) repeat	524 - 555	IPR003107-13
repeat	HAT (Half-A-TPR) repeat	567 - 605	IPR003107-14

Functions

		Description
EC Number
Subcellular Localization	Endoplasmic reticulum membrane ; Single-pass type I membrane protein Mitochondrion membrane ; Single-pass type I membrane protein Melanosome membrane ; Single-pass type I membrane protein	Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065) The palmitoylated form preferentially localizes to the perinuclear rough ER (PubMed:22314232) Localizes to endoplasmic reticulum mitochondria-associated membrane (MAMs) that connect the endoplasmic reticulum and the mitochondria (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

20 GO annotations of cellular component

Name	Definition
axon	The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
dendrite cytoplasm	All of the contents of a dendrite, excluding the surrounding plasma membrane.
dendritic spine	A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum lumen	The volume enclosed by the membranes of the endoplasmic reticulum.
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
endoplasmic reticulum quality control compartment	A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
glutamatergic synapse	A synapse that uses glutamate as a neurotransmitter.
integral component of lumenal side of endoplasmic reticulum membrane	The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the lumenal side of the membrane.
integral component of postsynaptic membrane	The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of presynaptic active zone membrane	The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
melanosome	A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
mitochondria-associated endoplasmic reticulum membrane	A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange.
neuronal cell body	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
ribosome	An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
rough endoplasmic reticulum	The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.
smooth endoplasmic reticulum	The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.

6 GO annotations of molecular function

Name	Definition
apolipoprotein binding	Binding to an apolipoprotein, the protein component of a lipoprotein complex.
calcium ion binding	Binding to a calcium ion (Ca2+).
carbohydrate binding	Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
ionotropic glutamate receptor binding	Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.
RNA binding	Binding to an RNA molecule or a portion thereof.
unfolded protein binding	Binding to an unfolded protein.

8 GO annotations of biological process

Name	Definition
aging	A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
clathrin-dependent endocytosis	An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles.
protein folding	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
protein folding in endoplasmic reticulum	A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation).
protein secretion	The controlled release of proteins from a cell.
synaptic vesicle endocytosis	A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms.
ubiquitin-dependent ERAD pathway	The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
viral protein processing	Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a viral protein.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O14967	CLGN	Calmegin	Homo sapiens (Human)	PR
Q96L12	CALR3	Calreticulin-3	Homo sapiens (Human)	PR
P27797	CALR	Calreticulin	Homo sapiens (Human)	PR
P52194	Clgn	Calmegin	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MEGKWLLCML	LVLGTAIVEA	HDGHDDDVID	IEDDLDDVIE	EVEDSKPDTT	APPSSPKVTY
70	80	90	100	110	120
KAPVPTGEVY	FADSFDRGTL	SGWILSKAKK	DDTDDEIAKY	DGKWEVEEMK	ESKLPGDKGL
130	140	150	160	170	180
VLMSRAKHHA	ISAKLNKPFL	FDTKPLIVQY	EVNFQNGIEC	GGAYVKLLSK	TPELNLDQFH
190	200	210	220	230	240
DKTPYTIMFG	PDKCGEDYKL	HFIFRHKNPK	TGIYEEKHAK	RPDADLKTYF	TDKKTHLYTL
250	260	270	280	290	300
ILNPDNSFEI	LVDQSVVNSG	NLLNDMTPPV	NPSREIEDPE	DRKPEDWDER	PKIPDPEAVK
310	320	330	340	350	360
PDDWDEDAPA	KIPDEEATKP	EGWLDDEPEY	VPDPDAEKPE	DWDEDMDGEW	EAPQIANPRC
370	380	390	400	410	420
ESAPGCGVWQ	RPVIDNPNYK	GKWKPPMIDN	PSYQGIWKPR	KIPNPDFFED	LEPFRMTPFS
430	440	450	460	470	480
AIGLELWSMT	SDIFFDNFII	CADRRIVDDW	ANDGWGLKKA	ADGAAEPGVV	GQMIEAAEER
490	500	510	520	530	540
PWLWVVYILT	VALPVFLVIL	FCCSGKKQTS	GMEYKKTDAP	QPDVKEEEEE	KEEEKDKGDE
550	560	570	580	590
EEEGEEKLEE	KQKSDAEEDG	GTVSQEEEDR	KPKAEEDEIL	NRSPRNRKPR	RE