P52194
PR
Gene name |
Clgn (Meg1) |
Protein name |
Calmegin |
Names |
A2/6, Calnexin-T, MEG 1 antigen |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:12745 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P52194
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P52194-F1 | Predicted | AlphaFoldDB |
30 variants for P52194
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs13479864 | 2 | R>H | No | EVA | |
| rs3388993052 | 15 | I>F | No | EVA | |
| rs255346150 | 24 | D>N | No | EVA | |
| rs3388992984 | 30 | D>Y | No | EVA | |
| rs3399166177 | 34 | N>H | No | EVA | |
| rs3388992819 | 68 | S>N | No | EVA | |
| rs3388995265 | 112 | V>I | No | EVA | |
| rs16789369 | 127 | E>K | No | EVA | |
| rs3388945415 | 129 | P>T | No | EVA | |
| rs3388995264 | 138 | I>V | No | EVA | |
| rs3388995255 | 197 | H>Q | No | EVA | |
| rs13472407 | 210 | A>V | No | EVA | |
| rs3388976469 | 223 | D>V | No | EVA | |
| rs247234640 | 241 | V>I | No | EVA | |
| rs3388991553 | 247 | V>A | No | EVA | |
| rs3388995497 | 271 | S>G | No | EVA | |
| rs3388964591 | 276 | E>K | No | EVA | |
| rs3399338111 | 290 | V>* | No | EVA | |
| rs16789437 | 291 | R>K | No | EVA | |
| rs3388987464 | 333 | W>* | No | EVA | |
| rs3388995259 | 374 | P>T | No | EVA | |
| rs3388993716 | 391 | I>N | No | EVA | |
| rs3388992983 | 420 | P>H | No | EVA | |
| rs3388998782 | 463 | V>M | No | EVA | |
| rs3388998797 | 464 | I>M | No | EVA | |
| rs3388987438 | 467 | E>* | No | EVA | |
| rs3388995282 | 480 | A>V | No | EVA | |
| rs16789483 | 541 | P>S | No | EVA | |
| rs16789484 | 542 | G>S | No | EVA | |
| rs16789485 | 548 | T>I | No | EVA |
No associated diseases with P52194
2 regional properties for P52194
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Calreticulin/calnexin, conserved site | 144 - 159 | IPR018124-1 |
| conserved_site | Calreticulin/calnexin, conserved site | 178 - 186 | IPR018124-2 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| protein folding chaperone | Binding to a protein or a protein-containing complex to assist the protein folding process. |
| unfolded protein binding | Binding to an unfolded protein. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| binding of sperm to zona pellucida | The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place. |
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| meiotic cell cycle | Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. |
| protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
| protein-containing complex assembly | The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. |
| single fertilization | The union of male and female gametes to form a zygote. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
| ubiquitin-dependent ERAD pathway | The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRFQGVGLCL | GLLFITVNAD | FMDDGVEVED | FSENSDESNI | KDEPSSGTFK | YKTPQPIGEV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YFTETFDSGN | LAGWVLSKAK | KDDMDSEIAI | YDGRWEIEEL | KENQVPGDRG | LVLKSKAKHH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AIAAVLEKPF | IFADKPLIVQ | YEVNFQDGID | CGGAYIKLLA | DTGDLILENF | YDKTSYTIMF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GPDKCGEDYK | LHLIFRHKHP | KTGVFEEKHA | KPPDVDLKEF | FTDRKTHLYT | LVMNPDDTFE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VLIDQKVVNQ | GTLLDDVVPP | INPPREIDDP | SDKKPEEWDD | RAKIPDPTAV | RPEDWDENEP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AQIEDSSAVK | PDGWLDDEPK | FIPNPKAEKP | EDWSDDMDGE | WEAPHIPNPA | CQIGCGEWKP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PMIDNPKYKG | IWRPPMINNP | NYQGLWSPQK | IPNPDYFEDD | HPFLLTSFSA | LGLELWSMTP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DIYFDNFIIC | SEKEVADQWA | TDGWELKIMV | ANANEPGVLR | QLVIAAEERP | WLWLMYLVMA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GLPVALVASF | CWPRKVKKKY | EDTGPKKTEL | CKLQSKAALE | QEAEEEKAPE | KPEDVQEEKK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PGEAEVVTVE | KEVIGEPEEK | SKEDRETLEG | QEEVSKLSKS | GSEDEMKDAD | ESPGSGDAPL |
| 610 | |||||
| KSLRKRRVRK | D |