Q80TR1
PR
Gene name |
Adgrl1 |
Protein name |
Adhesion G protein-coupled receptor L1 |
Names |
Calcium-independent alpha-latrotoxin receptor 1, CIRL-1, Latrophilin-1, Lectomedin-2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:330814 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q80TR1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2JX9 | NMR | - | A | 29-131 | PDB |
| 2JXA | NMR | - | A | 29-131 | PDB |
| 6SKA | X-ray | 386 A | D | 35-391 | PDB |
| AF-Q80TR1-F1 | Predicted | AlphaFoldDB |
65 variants for Q80TR1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388964613 | 6 | A>V | No | EVA | |
| rs3388964590 | 7 | A>S | No | EVA | |
| rs3388995520 | 45 | P>L | No | EVA | |
| rs3388995788 | 55 | V>D | No | EVA | |
| rs3388946928 | 98 | N>K | No | EVA | |
| rs3388992821 | 101 | Q>H | No | EVA | |
| rs3388964639 | 112 | P>S | No | EVA | |
| rs3399436775 | 204 | N>D | No | EVA | |
| rs3399344998 | 238 | K>* | No | EVA | |
| rs3398436706 | 238 | K>M | No | EVA | |
| rs864259211 | 350 | E>D | No | EVA | |
| rs3388995714 | 421 | A>S | No | EVA | |
| rs3388988364 | 493 | L>M | No | EVA | |
| rs3388995713 | 550 | S>N | No | EVA | |
| rs3388946871 | 557 | R>W | No | EVA | |
| rs3388992827 | 623 | L>I | No | EVA | |
| rs3388981761 | 641 | H>P | No | EVA | |
| rs3388988342 | 641 | H>Q | No | EVA | |
| rs3388995571 | 645 | M>L | No | EVA | |
| rs3388988341 | 662 | R>K | No | EVA | |
| rs3388988320 | 664 | P>H | No | EVA | |
| rs3388992770 | 672 | Q>R | No | EVA | |
| rs3388995547 | 679 | T>N | No | EVA | |
| rs3388993013 | 692 | F>L | No | EVA | |
| rs3388946897 | 692 | F>S | No | EVA | |
| rs3388992789 | 737 | A>P | No | EVA | |
| rs3388981778 | 746 | G>R | No | EVA | |
| rs3388976470 | 773 | V>I | No | EVA | |
| rs3388970770 | 788 | A>P | No | EVA | |
| rs3388988352 | 791 | H>N | No | EVA | |
| rs3389000448 | 804 | R>G | No | EVA | |
| rs3388995516 | 813 | Q>H | No | EVA | |
| rs3388976411 | 863 | V>L | No | EVA | |
| rs3388995702 | 864 | I>N | No | EVA | |
| rs3388995238 | 886 | R>H | No | EVA | |
| rs3388988310 | 887 | N>D | No | EVA | |
| rs3388987475 | 888 | T>I | No | EVA | |
| rs3388976458 | 900 | A>V | No | EVA | |
| rs3388987497 | 910 | K>R | No | EVA | |
| rs3399383020 | 929 | L>Q | No | EVA | |
| rs3399436726 | 936 | C>S | No | EVA | |
| rs3399383030 | 937 | L>Q | No | EVA | |
| rs3388976428 | 948 | E>D | No | EVA | |
| rs3398436687 | 976 | A>V | No | EVA | |
| rs3388995532 | 1002 | I>V | No | EVA | |
| rs3389000362 | 1010 | V>M | No | EVA | |
| rs3388976454 | 1019 | T>A | No | EVA | |
| rs3388988347 | 1030 | L>F | No | EVA | |
| rs3388976460 | 1034 | S>C | No | EVA | |
| rs3388946911 | 1048 | I>S | No | EVA | |
| rs3389000457 | 1052 | F>V | No | EVA | |
| rs3388995271 | 1093 | A>V | No | EVA | |
| rs3388970788 | 1115 | S>F | No | EVA | |
| rs3388987487 | 1117 | P>S | No | EVA | |
| rs3388946902 | 1119 | G>D | No | EVA | |
| rs3388970803 | 1124 | L>P | No | EVA | |
| rs3388995286 | 1145 | R>G | No | EVA | |
| rs3388995732 | 1187 | P>H | No | EVA | |
| rs3388993055 | 1211 | V>I | No | EVA | |
| rs3388993039 | 1214 | S>Y | No | EVA | |
| rs3388964587 | 1276 | K>E | No | EVA | |
| rs3389000461 | 1290 | A>V | No | EVA | |
| rs3388981756 | 1302 | P>S | No | EVA | |
| rs235934786 | 1339 | P>S | No | EVA | |
| rs3399554778 | 1447 | P>T | No | EVA |
No associated diseases with Q80TR1
9 regional properties for Q80TR1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPS motif | 792 - 844 | IPR000203 |
| domain | D-galactoside/L-rhamnose binding SUEL lectin domain | 40 - 129 | IPR000922 |
| domain | GPCR, family 2, extracellular hormone receptor domain | 471 - 536 | IPR001879 |
| domain | Olfactomedin-like domain | 134 - 393 | IPR003112 |
| domain | GPCR, family 2, latrophilin, C-terminal | 1107 - 1466 | IPR003334 |
| domain | GPCR, family 2-like, transmembrane domain | 854 - 1095 | IPR017981 |
| conserved_site | GPCR, family 2, secretin-like, conserved site | 1083 - 1098 | IPR017983 |
| domain | Latrophilin-1,, transmembrane domain | 851 - 1108 | IPR031234 |
| domain | GAIN domain, N-terminal | 545 - 768 | IPR032471 |
Functions
11 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| growth cone | The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of presynaptic membrane | The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic density | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
| presynaptic membrane | A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| carbohydrate binding | Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. |
| cell adhesion molecule binding | Binding to a cell adhesion molecule. |
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| latrotoxin receptor activity | Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| toxic substance binding | Binding to a toxic substance, a poisonous substance that causes damage to biological systems. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| adenylate cyclase-activating G protein-coupled receptor signaling pathway | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity and a subsequent increase in the intracellular concentration of cyclic AMP (cAMP). |
| calcium-mediated signaling using intracellular calcium source | The series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response. |
| cell surface receptor signaling pathway | The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
| heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell. |
| positive regulation of synapse assembly | Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. |
| positive regulation of synapse maturation | Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q594P2 | MYOC | Myocilin | Felis catus (Cat) (Felis silvestris catus) | PR |
| Q25C36 | OLFML3 | Olfactomedin-like protein 3 | Gallus gallus (Chicken) | PR |
| Q9IAK4 | OLFM1 | Noelin | Gallus gallus (Chicken) | PR |
| O97148 | mth | G-protein coupled receptor Mth | Drosophila melanogaster (Fruit fly) | PR |
| Q9VSE7 | mthl7 | Probable G-protein coupled receptor Mth-like 7 | Drosophila melanogaster (Fruit fly) | PR |
| P83119 | mthl12 | Probable G-protein coupled receptor Mth-like 12 | Drosophila melanogaster (Fruit fly) | PR |
| Q99972 | MYOC | Myocilin | Homo sapiens (Human) | PR |
| Q99784 | OLFM1 | Noelin | Homo sapiens (Human) | PR |
| Q8IZF3 | ADGRF4 | Adhesion G protein-coupled receptor F4 | Homo sapiens (Human) | PR |
| Q9UHX3 | ADGRE2 | Adhesion G protein-coupled receptor E2 | Homo sapiens (Human) | PR |
| Q86SQ4 | ADGRG6 | Adhesion G-protein coupled receptor G6 | Homo sapiens (Human) | PR |
| O88998 | Olfm1 | Noelin | Mus musculus (Mouse) | PR |
| Q80ZF8 | Adgrb3 | Adhesion G protein-coupled receptor B3 | Mus musculus (Mouse) | PR |
| Q62609 | Olfm1 | Noelin | Rattus norvegicus (Rat) | PR |
| Q2Q426 | ADGRE2 | Adhesion G protein-coupled receptor E2 | Macaca mulatta (Rhesus macaque) | PR |
| A4IIT5 | olfml2a | Olfactomedin-like protein 2A | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARLAAALWS | LCVTTVLVTS | ATQGLSRAGL | PFGLMRRELA | CEGYPIELRC | PGSDVIMVEN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ANYGRTDDKI | CDADPFQMEN | VQCYLPDAFK | IMSQRCNNRT | QCVVVAGSDA | FPDPCPGTYK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YLEVQYDCVP | YIFVCPGTLQ | KVLEPTSTHE | SEHQSGAWCK | DPLQAGDRIY | VMPWIPYRTD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TLTEYASWED | YVAARHTTTY | RLPNRVDGTG | FVVYDGAVFY | NKERTRNIVK | YDLRTRIKSG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ETVINTANYH | DTSPYRWGGK | TDIDLAVDEN | GLWVIYATEG | NNGRLVVSQL | NPYTLRFEGT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| WETGYDKRSA | SNAFMVCGVL | YVLRSVYVDD | DSEAAGNRVD | YAFNTNANRE | EPVSLAFPNP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YQFVSSVDYN | PRDNQLYVWN | NYFVVRYSLE | FGPPDPSAGP | ATSPPLSTTT | TARPTPLTST |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ASPAATTPLR | RAPLTTHPVG | AINQLGPDLP | PATAPAPSTR | RPPAPNLHVS | PELFCEPREV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RRVQWPATQQ | GMLVERPCPK | GTRGIASFQC | LPALGLWNPR | GPDLSNCTSP | WVNQVAQKIK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SGENAANIAS | ELARHTRGSI | YAGDVSSSVK | LMEQLLDILD | AQLQALRPIE | RESAGKNYNK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| MHKRERTCKD | YIKAVVETVD | NLLRPEALES | WKDMNATEQV | HTATMLLDVL | EEGAFLLADN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VREPARFLAA | KQNVVLEVTV | LNTEGQVQEL | VFPQEYPSEN | SIQLSANTIK | QNSRNGVVKV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VFILYNNLGL | FLSTENATVK | LAGEAGTGGP | GGASLVVNSQ | VIAASINKES | SRVFLMDPVI |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FTVAHLEAKN | HFNANCSFWN | YSERSMLGYW | STQGCRLVES | NKTHTTCACS | HLTNFAVLMA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| HREIYQGRIN | ELLLSVITWV | GIVISLVCLA | ICISTFCFLR | GLQTDRNTIH | KNLCINLFLA |
| 910 | 920 | 930 | 940 | 950 | 960 |
| ELLFLVGIDK | TQYEVACPIF | AGLLHYFFLA | AFSWLCLEGV | HLYLLLVEVF | ESEYSRTKYY |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| YLGGYCFPAL | VVGIAAAIDY | RSYGTEKACW | LRVDNYFIWS | FIGPVSFVIV | VNLVFLMVTL |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| HKMIRSSSVL | KPDSSRLDNI | KSWALGAIAL | LFLLGLTWAF | GLLFINKESV | VMAYLFTTFN |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| AFQGVFIFVF | HCALQKKVHK | EYSKCLRHSY | CCIRSPPGGT | HGSLKTSAMR | SNTRYYTGTQ |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| SRIRRMWNDT | VRKQTESSFM | AGDINSTPTL | NRGTMGNHLL | TNPVLQPRGG | TSPYNTLIAE |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| SVGFNPSSPP | VFNSPGSYRE | PKHPLGGREA | CGMDTLPLNG | NFNNSYSLRS | GDFPPGDGGP |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| EPPRGRNLAD | AAAFEKMIIS | ELVHNNLRGA | SGGAKGPPPE | PPVPPVPGVS | EDEAGGPGSA |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| DRAEIELLYK | ALEEPLLLPR | AQSVLYQSDL | DESESCTAED | GATSRPLSSP | PGRDSLYASG |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| ANLRDSPSYP | DSSPEGPNEA | LPPPPPAPPG | PPEIYYTSRP | PALVARNPLQ | GYYQVRRPSH |
| 1450 | 1460 | ||||
| EGYLAAPSLE | GPGPDGDGQM | QLVTSL |