O97148
PR
Gene name |
mth (CG6936) |
Protein name |
G-protein coupled receptor Mth |
Names |
Protein methuselah |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG6936 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for O97148
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1FJR | X-ray | 230 A | A/B | 25-219 | PDB |
| 2PZX | X-ray | 350 A | A/B/C/D | 25-212 | PDB |
| AF-O97148-F1 | Predicted | AlphaFoldDB |
7 variants for O97148
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 54 | L>I | strain: MA97_6 [UniProt] | No | ||
| 132 | S>A | strain: ZIM(S)49 and ZIM(H)44 [UniProt] | No | ||
| 151 | D>N | strain: CT97_3, MFL97_1 and ZIM(S)37 [UniProt] | No | ||
| 281 | F>V | strain: ZIM(S)49 and ZIM(H)44 [UniProt] | No | ||
| 357 | H>N | strain: DPF96_3.0, HFL97_15, JFL97_1, JFL97_9 and ZIM(S)37 [UniProt] | No | ||
| 387 | T>N | strain: ZIM(S)35 [UniProt] | No | ||
| 407 | A>V | strain: ZIM(H)23 [UniProt] | No |
No associated diseases with O97148
4 regional properties for O97148
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Adenylyl cyclase class-3/4/guanylyl cyclase | 325 - 571 | IPR001054-1 |
| domain | Adenylyl cyclase class-3/4/guanylyl cyclase | 1023 - 1241 | IPR001054-2 |
| conserved_site | Adenylyl cyclase class-4/guanylyl cyclase, conserved site | 498 - 521 | IPR018297-1 |
| conserved_site | Adenylyl cyclase class-4/guanylyl cyclase, conserved site | 1175 - 1198 | IPR018297-2 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| presynapse | The part of a synapse that is part of the presynaptic cell. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein-coupled peptide receptor activity | Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| peptide binding | Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| aging | A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700). |
| cell surface receptor signaling pathway | The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
| determination of adult lifespan | The pathways that regulate the duration of the adult phase of the life-cycle of an animal. |
| G protein-coupled receptor signaling pathway | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
| response to heat | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. |
| response to paraquat | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paraquat stimulus. |
| response to reactive oxygen species | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. |
| response to starvation | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment. |
| synaptic vesicle exocytosis | Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9W0R6 | mthl9 | Probable G-protein coupled receptor Mth-like 9 | Drosophila melanogaster (Fruit fly) | PR |
| Q9W0R5 | mthl10 | Probable G-protein coupled receptor Mth-like 10 | Drosophila melanogaster (Fruit fly) | PR |
| Q9VSE7 | mthl7 | Probable G-protein coupled receptor Mth-like 7 | Drosophila melanogaster (Fruit fly) | PR |
| P83119 | mthl12 | Probable G-protein coupled receptor Mth-like 12 | Drosophila melanogaster (Fruit fly) | PR |
| Q8IZF3 | ADGRF4 | Adhesion G protein-coupled receptor F4 | Homo sapiens (Human) | PR |
| Q9UHX3 | ADGRE2 | Adhesion G protein-coupled receptor E2 | Homo sapiens (Human) | PR |
| Q86SQ4 | ADGRG6 | Adhesion G-protein coupled receptor G6 | Homo sapiens (Human) | PR |
| Q80TR1 | Adgrl1 | Adhesion G protein-coupled receptor L1 | Mus musculus (Mouse) | PR |
| Q2Q426 | ADGRE2 | Adhesion G protein-coupled receptor E2 | Macaca mulatta (Rhesus macaque) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKTLLVLRIS | TVILVVLVIQ | KSYADILECD | YFDTVDISAA | QKLQNGSYLF | EGLLVPAILT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GEYDFRILPD | DSKQKVARHI | RGCVCKLKPC | VRFCCPHDHI | MDNGVCYDNM | SDEELAELDP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FLNVTLDDGS | VSRRHFKNEL | IVQWDLPMPC | DGMFYLDNRE | EQDKYTLFEN | GTFFRHFDRV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TLRKREYCLQ | HLTFADGNAT | SIRIAPHNCL | IVPSITGQTV | VMISSLICMV | LTIAVYLFVK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KLQNLHGKCF | ICYMVCLFMG | YLFLLLDLWQ | ISISFCKPAG | FLGYFFVMAA | FFWLSVISLH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LWNTFRGSSH | KANRFLFEHR | FLAYNTYAWG | MAVVLTGITV | LADNIVENQD | WNPRVGHEGH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| CWIYTQAWSA | MLYFYGPMVF | LIAFNITMFI | LTAKRILGVK | KDIQNFAHRQ | ERKQKLNSDK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QTYTFFLRLF | IIMGLSWSLE | IGSYFSQSNQ | TWANVFLVAD | YLNWSQGIII | FILFVLKRST |
| 490 | 500 | 510 | |||
| WRLLQESIRG | EGEEVNNSEE | EISLENTTTR | NVLL |