Q2Q426

PR
Gene name
ADGRE2 (EMR2)
Protein name
Adhesion G protein-coupled receptor E2
Names
Species
Macaca mulatta (Rhesus macaque)
KEGG Pathway
mcc:654420
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

764-822 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2Q426

Entry ID Method Resolution Chain Position Source
AF-Q2Q426-F1 Predicted AlphaFoldDB

No variants for Q2Q426

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2Q426

No associated diseases with Q2Q426

18 regional properties for Q2Q426

Type Name Position InterPro Accession
ptm EGF-type aspartate/asparagine hydroxylation site 82 - 93 IPR000152-1
ptm EGF-type aspartate/asparagine hydroxylation site 133 - 144 IPR000152-2
ptm EGF-type aspartate/asparagine hydroxylation site 177 - 188 IPR000152-3
ptm EGF-type aspartate/asparagine hydroxylation site 226 - 237 IPR000152-4
domain GPS motif 471 - 522 IPR000203
domain EGF-like domain 25 - 63 IPR000742-1
domain EGF-like domain 64 - 115 IPR000742-2
domain EGF-like domain 116 - 159 IPR000742-3
domain EGF-like domain 160 - 208 IPR000742-4
domain EGF-like domain 209 - 257 IPR000742-5
domain EGF-like calcium-binding domain 64 - 115 IPR001881-1
domain EGF-like calcium-binding domain 116 - 159 IPR001881-2
domain EGF-like calcium-binding domain 160 - 208 IPR001881-3
domain EGF-like calcium-binding domain 209 - 257 IPR001881-4
domain GPCR, family 2-like, transmembrane domain 529 - 775 IPR017981
conserved_site GPCR, family 2, secretin-like, conserved site 763 - 778 IPR017983
conserved_site EGF-like calcium-binding, conserved site 160 - 186 IPR018097-1
conserved_site EGF-like calcium-binding, conserved site 209 - 235 IPR018097-2

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Cell projection, ruffle membrane ; Multi-pass membrane protein
  • Localized at the leading edge of migrating cells
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
leading edge membrane The portion of the plasma membrane surrounding the leading edge of a motile cell.
ruffle membrane The portion of the plasma membrane surrounding a ruffle.

3 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
chondroitin sulfate binding Binding to chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc).
G protein-coupled receptor activity Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.

6 GO annotations of biological process

Name Definition
adenylate cyclase-activating G protein-coupled receptor signaling pathway A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity and a subsequent increase in the intracellular concentration of cyclic AMP (cAMP).
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cell surface receptor signaling pathway The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
granulocyte chemotaxis The movement of a granulocyte in response to an external stimulus.
inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O97148 mth G-protein coupled receptor Mth Drosophila melanogaster (Fruit fly) PR
Q9VSE7 mthl7 Probable G-protein coupled receptor Mth-like 7 Drosophila melanogaster (Fruit fly) PR
P83119 mthl12 Probable G-protein coupled receptor Mth-like 12 Drosophila melanogaster (Fruit fly) PR
Q8IZF3 ADGRF4 Adhesion G protein-coupled receptor F4 Homo sapiens (Human) PR
Q86SQ4 ADGRG6 Adhesion G-protein coupled receptor G6 Homo sapiens (Human) PR
Q9UHX3 ADGRE2 Adhesion G protein-coupled receptor E2 Homo sapiens (Human) PR
Q80TR1 Adgrl1 Adhesion G protein-coupled receptor L1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MGGRVFLAFC VWLTLLGAET QDSRDCARWC PENSSCVNAT ACRCNPGFSS SSEIFTSPTE
70 80 90 100 110 120
ICDDINECVP PSKVSCGKSS DCRNTEGSYD CVCNPGYELV SGAKTFKNES ENTCQDVDEC
130 140 150 160 170 180
QQNPRLCKSY GTCVNTLGSF TCQCLPGFKF KPEDPKLCTD VNECTSGQNP CHSSTHCLNN
190 200 210 220 230 240
VGSYQCRCRP GWQPIPGSPN GPNNTICEDV DECSSGLHQC DNSTVCFNTV GSYTCRCRPG
250 260 270 280 290 300
WEPKHGIPNN QKDTVCKDMN FPTWTLPPGV HSQTLSQFFN KVQDLDRDFK TSSAKVTIQS
310 320 330 340 350 360
ILKELDELLE APGDLETLPR FQQHCVATHL LDGLEDVLRG LSKNPSIGLL NFSYPAGTEF
370 380 390 400 410 420
SLEVQKQVDR NVTLRQNQAT MQLHWNLAQK SGDPGPSVVG LVSVPGMGKL LAEAPLVSEP
430 440 450 460 470 480
ENQVVRNETH QGLLPILLSD VISAFLSNND TQNLSSPVTF IFSHRSVIPR RKVLCVFWEH
490 500 510 520 530 540
GQNGCGHWAT TGCSTMDTRD TSTICRCTHL SSFAVLMAPY DVQEEDPVLT VITYMGLSLS
550 560 570 580 590 600
LLCLLLAALT FLLCKAIQNI STSLHLQLSL CLLLAHLLFL VAIDRTEHEV LCAIIASALH
610 620 630 640 650 660
YLYLAAFTWM LLEALYLFLT ARNLMVVNYS SINRFTKKLM FPVAYGVPAV TVAISAASRP
670 680 690 700 710 720
HLYGTPSRCW LQPEKGFIWG FLGPVCAIFS VNLALLLVTL WILKNRLSSL NNEVSTLQNT
730 740 750 760 770 780
RMLAFKATAQ LFILGCTWCL GILQVGPAAR VMAYLFTIIN SLQGVFIFLV YCLLSQQVRE
790 800 810 820
QYRKWSKGFR KLRTESEMHT LSSSAKRDTP KPSTPGLLGL QS