Q9VSE7

PR
Gene name
mthl7 (CG7476)
Protein name
Probable G-protein coupled receptor Mth-like 7
Names
Protein methuselah-like 7
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG7476
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

376-450 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9VSE7

Entry ID Method Resolution Chain Position Source
AF-Q9VSE7-F1 Predicted AlphaFoldDB

No variants for Q9VSE7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VSE7

No associated diseases with Q9VSE7

10 regional properties for Q9VSE7

Type Name Position InterPro Accession
domain GPS motif 815 - 868 IPR000203
repeat Thrombospondin type-1 (TSP1) repeat 291 - 343 IPR000884-1
repeat Thrombospondin type-1 (TSP1) repeat 345 - 398 IPR000884-2
repeat Thrombospondin type-1 (TSP1) repeat 400 - 453 IPR000884-3
repeat Thrombospondin type-1 (TSP1) repeat 455 - 508 IPR000884-4
domain GPCR, family 2, extracellular hormone receptor domain 491 - 576 IPR001879
domain GPCR, family 2-like, transmembrane domain 877 - 1151 IPR017981
conserved_site GPCR, family 2, secretin-like, conserved site 1139 - 1154 IPR017983
domain GAIN domain, N-terminal 595 - 793 IPR032471
domain Adhesion G protein-coupled receptor B, N-terminal domain 30 - 201 IPR043838

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
G protein-coupled receptor activity Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.

4 GO annotations of biological process

Name Definition
cell surface receptor signaling pathway The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
determination of adult lifespan The pathways that regulate the duration of the adult phase of the life-cycle of an animal.
G protein-coupled receptor signaling pathway The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
response to starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9W0R6 mthl9 Probable G-protein coupled receptor Mth-like 9 Drosophila melanogaster (Fruit fly) PR
Q9W0R5 mthl10 Probable G-protein coupled receptor Mth-like 10 Drosophila melanogaster (Fruit fly) PR
O97148 mth G-protein coupled receptor Mth Drosophila melanogaster (Fruit fly) PR
P83119 mthl12 Probable G-protein coupled receptor Mth-like 12 Drosophila melanogaster (Fruit fly) PR
Q8IZF3 ADGRF4 Adhesion G protein-coupled receptor F4 Homo sapiens (Human) PR
Q9UHX3 ADGRE2 Adhesion G protein-coupled receptor E2 Homo sapiens (Human) PR
Q86SQ4 ADGRG6 Adhesion G-protein coupled receptor G6 Homo sapiens (Human) PR
Q80TR1 Adgrl1 Adhesion G protein-coupled receptor L1 Mus musculus (Mouse) PR
Q2Q426 ADGRE2 Adhesion G protein-coupled receptor E2 Macaca mulatta (Rhesus macaque) PR
10 20 30 40 50 60
MRLPWVIFCT VLLLIFTNNS NADIPGCNYY DTVDISYIER QNDSYLYDDI EIPASLTGYY
70 80 90 100 110 120
EFRQFGDGSI TPIEKHLRAC VCSVRPCIRI CCPAKNFLAN GKCDDGLKEE LARFKPYIYF
130 140 150 160 170 180
TYMDLQARVP LTDMAIIRDE FFDCDEMIYI SDFNYFLEEV SIQIFNKCGL IVWFQDGKFW
190 200 210 220 230 240
VTVDLFMEKQ DYCLYRHNFD SDFPKSMWII RHRCTSHISP GSLEILIITM ICFVLTIAVY
250 260 270 280 290 300
LYIKKLRNVT GKCIVCCIVS RFIQCLIMIL DHLNLLNGIC SPAGYSSHFF RMASNLWLSV
310 320 330 340 350 360
ISYHTWKVLT SLNRVDPNYR FLRYNAFVWS TAAIMTGSIY IVNQIWENDP SKWNWLPLVG
370 380 390 400 410 420
FIRCSVKDWH PSVWIYISGP SLALSTFNVA MFALTAIYIR KVKGGINKFT NEEEGRINCI
430 440 450 460 470 480
NFDSQTYLQF LRLSIVMGLT WIFNVIPYSA RLHIFWEWVG IISEYFHSAF GIVLFVLLVL
490
KRSTWTLMMD S