Q9W0R5

PR
Gene name
mthl10 (mth2, CG17061)
Protein name
Probable G-protein coupled receptor Mth-like 10
Names
Protein methuselah-like 10
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG17061
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

411-483 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9W0R5

Entry ID Method Resolution Chain Position Source
AF-Q9W0R5-F1 Predicted AlphaFoldDB

1 variants for Q9W0R5

Variant ID(s) Position Change Description Diseaes Association Provenance
150 M>V strain: ZIM(S)24 [UniProt] No

No associated diseases with Q9W0R5

2 regional properties for Q9W0R5

Type Name Position InterPro Accession
domain Glycosyl transferase, family 1 297 - 464 IPR001296
domain ALG11 mannosyltransferase, N-terminal 61 - 267 IPR031814

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
G protein-coupled receptor activity Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.

4 GO annotations of biological process

Name Definition
cell surface receptor signaling pathway The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
determination of adult lifespan The pathways that regulate the duration of the adult phase of the life-cycle of an animal.
G protein-coupled receptor signaling pathway The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
response to starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O97148 mth G-protein coupled receptor Mth Drosophila melanogaster (Fruit fly) PR
P83119 mthl12 Probable G-protein coupled receptor Mth-like 12 Drosophila melanogaster (Fruit fly) PR
Q9W0R6 mthl9 Probable G-protein coupled receptor Mth-like 9 Drosophila melanogaster (Fruit fly) PR
Q9VSE7 mthl7 Probable G-protein coupled receptor Mth-like 7 Drosophila melanogaster (Fruit fly) PR
10 20 30 40 50 60
MPKKIHQPGG SLYCGVTLLG VLCLVVFRLI PGIPFGTYVM AERDHYHTID DPNVPCNFYD
70 80 90 100 110 120
TVNLTGHRLF PNGSYDYYGT IVPAELVGTY DYIHSSLTER IEVREHVRGC VCKFKSCLNI
130 140 150 160 170 180
CCPWRQVFNS EVDGCIIDHS DNRTWPDPPM LNITFRNEST ILVNMFTQFA IQSFRPCPKM
190 200 210 220 230 240
FSLQPETNNW DDYLLFENGS MLRVDDKLLI RKNEFCMVPT YVNESDMFYT IHPANCDMQD
250 260 270 280 290 300
DHSTVKIINS YAMMFSIPFM MLTIAVYLLI PELRNQHGKS LVCYLIGLSV GYSSLCYVQL
310 320 330 340 350 360
YQVDATGVTC KVFGYTAYFF FMGAYMWLSV ISFDLWHNFR GTRGINRFQE KKRFLFYSLY
370 380 390 400 410 420
SWGIALVFLA FTYCAQQLTN LPANLKPGIG DGVYCWLDMS NWAAMIYFYG PILAIVVANT
430 440 450 460 470 480
IMFIMTAIKI HGVQREMARI IASENSTKNL RTEKDKRFYR AWSNYRFGLF LRLFLIMGIT
490 500 510 520 530 540
WLTELISYFV GSDKGWSKLF YISDLANAMQ GFLIFMLFVM KKKVKHLITN RCSSVRDGSN
550 560 570 580
QRQSQYSTKT TSSSVANLSL HEKPSVEKPL VISSSVDPQK TTIFR