Q80ZF8
PR
Gene name |
Adgrb3 (Bai3) |
Protein name |
Adhesion G protein-coupled receptor B3 |
Names |
Brain-specific angiogenesis inhibitor 3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:210933 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q80ZF8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q80ZF8-F1 | Predicted | AlphaFoldDB |
46 variants for Q80ZF8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs1134270660 | 10 | Y>* | No | EVA | |
| rs1135006934 | 17 | L>M | No | EVA | |
| rs3388460544 | 183 | N>H | No | EVA | |
| rs3389747213 | 292 | S>F | No | EVA | |
| rs3389756508 | 312 | Q>H | No | EVA | |
| rs3413085970 | 313 | V>L | No | EVA | |
| rs3389756510 | 315 | T>P | No | EVA | |
| rs3389763473 | 340 | A>T | No | EVA | |
| rs3389756484 | 342 | C>W | No | EVA | |
| rs3389734899 | 343 | P>T | No | EVA | |
| rs3388461610 | 348 | W>S | No | EVA | |
| rs3388461326 | 368 | R>* | No | EVA | |
| rs1135064861 | 376 | Q>* | No | EVA | |
| rs3388460493 | 485 | A>T | No | EVA | |
| rs3388461478 | 528 | P>S | No | EVA | |
| rs3389763505 | 537 | C>* | No | EVA | |
| rs3388460893 | 628 | D>E | No | EVA | |
| rs3388461025 | 646 | F>C | No | EVA | |
| rs3388461324 | 658 | K>T | No | EVA | |
| rs3388460968 | 663 | D>Y | No | EVA | |
| rs3388461265 | 674 | L>I | No | EVA | |
| rs3388460675 | 681 | F>Y | No | EVA | |
| rs3389680737 | 761 | V>* | No | EVA | |
| rs3388461425 | 792 | I>V | No | EVA | |
| rs3388461670 | 804 | E>A | No | EVA | |
| rs3388461050 | 862 | L>W | No | EVA | |
| rs3388460646 | 877 | P>T | No | EVA | |
| rs3388461819 | 945 | T>I | No | EVA | |
| rs3388461072 | 955 | S>L | No | EVA | |
| rs3388460826 | 969 | A>P | No | EVA | |
| rs3388461124 | 984 | L>V | No | EVA | |
| rs3388461395 | 985 | C>* | No | EVA | |
| rs3388460622 | 986 | L>V | No | EVA | |
| rs3413090025 | 993 | L>F | No | EVA | |
| rs3388461595 | 1030 | A>V | No | EVA | |
| rs3388461503 | 1091 | T>I | No | EVA | |
| rs3388461110 | 1098 | S>Y | No | EVA | |
| rs3388460427 | 1103 | C>S | No | EVA | |
| rs3388461159 | 1116 | A>G | No | EVA | |
| rs3388461507 | 1134 | V>M | No | EVA | |
| rs3388461808 | 1356 | M>I | No | EVA | |
| rs224204028 | 1361 | M>I | No | EVA | |
| rs3388460588 | 1419 | Y>C | No | EVA | |
| rs3388461323 | 1449 | D>A | No | EVA | |
| rs3388460760 | 1483 | T>S | No | EVA | |
| rs3388461055 | 1503 | W>* | No | EVA |
No associated diseases with Q80ZF8
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynapse | The part of a synapse that is part of the post-synaptic cell. |
| synaptic cleft | The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| adenylate cyclase-activating G protein-coupled receptor signaling pathway | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity and a subsequent increase in the intracellular concentration of cyclic AMP (cAMP). |
| cell surface receptor signaling pathway | The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
| maintenance of synapse structure | A process that preserves the structural organistation and orientation of a synaptic cellular component such as the synaptic cytoskeleton and molecular scaffolds. |
| motor learning | Any process in which an organism acquires a novel neuromuscular action or movement as the result of experience. |
| myoblast fusion | A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. |
| negative regulation of angiogenesis | Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis. |
| neuron remodeling | The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development. |
| positive regulation of synapse assembly | Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. |
| regulation of dendrite morphogenesis | Any process that modulates the frequency, rate or extent of dendrite morphogenesis. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKAVRNLLIY | IFSTYLLVMF | GFNAAQDFWC | STLVKGVIYG | SYSVSEMFPK | NFTNCTWTLE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NPDPTKYSIY | LKFSKKDLSC | SNFSLLAYQF | DHFSHEKIKD | LLRKNHSIMQ | LCSSKNAFVF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LQYDKNFIQI | RRVFPTDFPG | LQKKVEEDQK | SFFEFLVLNK | VSPSQFGCHV | LCTWLESCLK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SENGRTESCG | IMYTKCTCPQ | HLGEWGIDDQ | SLVLLNNVVL | PLNEQTEGCL | TQELQTTQVC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NLTREAKRPP | KEEFGMMGDH | TIKSQRPRSV | HEKRVPQEQA | DAAKFMAQTG | ESGVEEWSQW |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SACSVTCGQG | SQVRTRTCVS | PYGTHCSGPL | RESRVCNNTA | LCPVHGVWEE | WSPWSLCSFT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| CGRGQRTRTR | SCTPPQYGGR | PCEGPETHHK | PCNIALCPVD | GQWQEWSSWS | HCSVTCSNGT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QQRSRQCTAA | AHGGSECRGP | WAESRECYNP | ECTANGQWNQ | WGHWSGCSKS | CDGGWERRMR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TCQGAAVTGQ | QCEGTGEEVR | RCSEQRCPAP | YEICPEDYLI | SMVWKRTPAG | DLAFNQCPLN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ATGTTSRRCS | LSLHGVASWE | QPSFARCISN | EYRHLQHSIK | EHLAKGQRML | AGDGMSQVTK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TLLDLTQRKN | FYAGDLLVSV | EILRNVTDTF | KRASYIPASD | GVQNFFQIVS | NLLDEENKEK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| WEDAQQIYPG | SIELMQVIED | FIHIVGMGMM | DFQNSYLMTG | NVVASIQKLP | AASVLTDINF |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PMKGRKGMVD | WARNSEDRVV | IPKSIFTPVS | SKELDESSVF | VLGAVLYKNL | DLILPTLRNY |
| 790 | 800 | 810 | 820 | 830 | 840 |
| TVVNSKVIVV | TIRPEPKTTD | SFLEIELAHL | ANGTLNPYCV | LWDDSKSNES | LGTWSTQGCK |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TVLTDASHTK | CLCDRLSTFA | ILAQQPREIV | MESSGTPSVT | LIVGSGLSCL | ALITLAVVYA |
| 910 | 920 | 930 | 940 | 950 | 960 |
| ALWRYIRSER | SIILINFCLS | IISSNILILV | GQTQTHNKSI | CTTTTAFLHF | FFLASFCWVL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| TEAWQSYMAV | TGKIRTRLIR | KRFLCLGWGL | PALVVATSVG | FTRTKGYGTD | HYCWLSLEGG |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| LLYAFVGPAA | AVVLVNMVIG | ILVFNKLVSR | DGILDKKLKH | RAGQMSEPHS | GLTLKCAKCG |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| VVSTTALSAT | TASNAMASLW | SSCVVLPLLA | LTWMSAVLAM | TDKRSILFQI | LFAVFDSLQG |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| FVIVMVHCIL | RREVQDAFRC | RLRNCQDPIN | ADSSSSFPNG | HAQIMTDFEK | DVDIACRSVL |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| HKDIGPCRAA | TITGTLSRIS | LNDDEEEKGT | NPEGLSYSTL | PGNVISKVII | QQPTGLHMPM |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| SMNELSNPCL | KKENTELRRT | VYLCTDDNLR | GADMDIVHPQ | ERMMESDYIV | MPRSSVSTQP |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| SMKEESKMNI | GMETLPHERL | LHYKVNPEFN | MNPPVMDQFN | MNLDQHLAPQ | EHMQNLPFEP |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| RTAVKNFMAS | ELDDNVGLSR | SETGSTISMS | SLERRKSRYS | DLDFEKVMHT | RKRHMELFQE |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| LNQKFQTLDR | FRDIPNTSSM | ENPAPNKNPW | DTFKPPSEYQ | HYTTINVLDT | EAKDTLELRP |
| 1510 | 1520 | ||||
| AEWEKCLNLP | LDVQEGDFQT | EV |