Q9IAK4

PR
Gene name
OLFM1 (NOEL, NOEL1)
Protein name
Noelin
Names
Neuronal olfactomedin-related ER localized protein, Olfactomedin-1, Pancortin
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:395535
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

7-239 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9IAK4

Entry ID Method Resolution Chain Position Source
AF-Q9IAK4-F1 Predicted AlphaFoldDB

15 variants for Q9IAK4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs736303757 121 Y>D No Ensembl
rs736995751 122 V>G No Ensembl
rs733525184 123 E>G No Ensembl
rs735547753 129 M>R No Ensembl
rs732624103 237 I>L No Ensembl
rs733951366 250 M>R No Ensembl
rs741436087 251 T>A No Ensembl
rs738749539 316 Q>K No Ensembl
rs735291072 355 I>T No Ensembl
rs732507167 387 L>P No Ensembl
rs735883709 395 T>P No Ensembl
rs736547556 399 K>T No Ensembl
rs733082652 408 I>T No Ensembl
rs733722138 422 T>P No Ensembl
rs741201762 426 Y>S No Ensembl

No associated diseases with Q9IAK4

No regional properties for Q9IAK4

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9IAK4

Functions

Description
EC Number
Subcellular Localization
  • Secreted
  • Synapse
  • Endoplasmic reticulum
  • Cell projection, axon
  • Perikaryon
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
axonal growth cone The migrating motile tip of a growing nerve cell axon.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
perikaryon The portion of the cell soma (neuronal cell body) that excludes the nucleus.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

10 GO annotations of biological process

Name Definition
atrioventricular valve formation The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
cardiac epithelial to mesenchymal transition A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
negative regulation of gene expression Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
neuronal signal transduction The process in which an activated neuronal cell receptor conveys information down a signaling pathway, resulting in a change in the function or state of a cell. This process may be intracellular or intercellular.
positive regulation of apoptotic process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of epithelial to mesenchymal transition Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
regulation of axon extension Any process that modulates the rate, direction or extent of axon extension.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q594P2 MYOC Myocilin Felis catus (Cat) (Felis silvestris catus) PR
Q25C36 OLFML3 Olfactomedin-like protein 3 Gallus gallus (Chicken) PR
Q99972 MYOC Myocilin Homo sapiens (Human) PR
Q99784 OLFM1 Noelin Homo sapiens (Human) PR
Q80TR1 Adgrl1 Adhesion G protein-coupled receptor L1 Mus musculus (Mouse) PR
O88998 Olfm1 Noelin Mus musculus (Mouse) PR
Q62609 Olfm1 Noelin Rattus norvegicus (Rat) PR
A4IIT5 olfml2a Olfactomedin-like protein 2A Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MSVPLLKIGV VLSTMAMITN WMSQTLPSLV GLNTTKLTAA SGGTLDRSTG VLPTNPEESW
70 80 90 100 110 120
QVYSSAQDSE GRCICTVVAP QQTMCSRDAR TKQLRQLLEK VQNMSQSIEV LDRRTQRDLQ
130 140 150 160 170 180
YVEKMENQMR GLESKFKQVE ESHKQHLARQ FKAIKAKMEE LRPLIPVLEE YKADAKLVLQ
190 200 210 220 230 240
FKEEVQNLTS VLNELQEEIG AYDYEELQNR VSNLEERLRA CMQKLACGKL TGISDPITIK
250 260 270 280 290 300
TSGSRFGSWM TDPLAPEGEN KVWYMDSYHN NRFVREYKSM ADFMNTDNFT SHRLPHPWSG
310 320 330 340 350 360
TGQVVYNGSI YFNKYQSHII IRFDLKTETI LKTRSLDYAG YNNMYHYAWG GHSDIDLMVD
370 380 390 400 410 420
ENGLWAVYAT NQNAGNIVIS KLDPNTLQSL QTWNTSYPKR SAGEAFIICG TLYVTNGYSG
430 440 450 460 470 480
GTKVHYAYQT NASTYEYIDI PFQNKYSHIS MLDYNPKDRA LYAWNNGHQI LYNVTLFHVI
RSDEL