Q62893
PR
Gene name |
Amhr2 |
Protein name |
Anti-Muellerian hormone type-2 receptor |
Names |
Anti-Muellerian hormone type II receptor, AMH type II receptor, C14, MIS type II receptor, MISRII, MRII |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:29530 |
EC number |
2.7.11.30: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q62893
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q62893-F1 | Predicted | AlphaFoldDB |
No variants for Q62893
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q62893 | |||||
No associated diseases with Q62893
1 regional properties for Q62893
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 201 - 511 | IPR000719 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.30 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| activin receptor complex | A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
9 GO annotations of molecular function
| Name | Definition |
|---|---|
| activin binding | Binding to activin, a dimer of inhibin-beta subunits. |
| activin receptor activity | Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta. |
| anti-Mullerian hormone receptor activity | Combining with anti-Mullerian hormone to initiate a change in cell activity. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| hormone binding | Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor. |
| metal ion binding | Binding to a metal ion. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| transforming growth factor beta receptor activity, type II | Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| activin receptor signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| anti-Mullerian hormone signaling pathway | The series of molecular signals initiated by the binding of anti-Mullerian hormone to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| cellular response to growth factor stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. |
| female gonad development | The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure. |
| male gonad development | The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure. |
| negative regulation of anti-Mullerian hormone signaling pathway | Any process that stops, prevents or reduces the frequency, rate or extent of anti-Mullerian hormone signaling pathway. |
| pathway-restricted SMAD protein phosphorylation | The process of introducing a phosphate group on to a pathway restricted SMAD protein. A pathway restricted SMAD protein is an effector protein that acts directly downstream of the transforming growth factor family receptor. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| sex differentiation | The establishment of the sex of an organism by physical differentiation. |
| transforming growth factor beta receptor signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q95126 | ACVR2B | Activin receptor type-2B | Bos taurus (Bovine) | PR |
| Q90670 | ACVR2B | Activin receptor type-2B | Gallus gallus (Chicken) | PR |
| Q90999 | TGFBR2 | TGF-beta receptor type-2 | Gallus gallus (Chicken) | PR |
| Q13705 | ACVR2B | Activin receptor type-2B | Homo sapiens (Human) | PR |
| P37173 | TGFBR2 | TGF-beta receptor type-2 | Homo sapiens (Human) | PR |
| Q62312 | Tgfbr2 | TGF-beta receptor type-2 | Mus musculus (Mouse) | PR |
| P27040 | Acvr2b | Activin receptor type-2B | Mus musculus (Mouse) | PR |
| Q8K592 | Amhr2 | Anti-Muellerian hormone type-2 receptor | Mus musculus (Mouse) | PR |
| Q66T47 | ACVR2B | Activin receptor type-2B | Sus scrofa (Pig) | PR |
| P38438 | Tgfbr2 | TGF-beta receptor type-2 | Rattus norvegicus (Rat) | PR |
| P80201 | Acvr1 | Activin receptor type-1 | Rattus norvegicus (Rat) | PR |
| P38445 | Acvr2b | Activin receptor type-2B | Rattus norvegicus (Rat) | PR |
| P70539 | Acvr1c | Activin receptor type-1C | Rattus norvegicus (Rat) | PR |
| P50488 | daf-4 | Cell surface receptor daf-4 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLGTLGLWTL | LPAAAQVSPN | RRTCVFFEAP | GVRGSTKTLG | EVVDAGPGPP | KGIRCLYSHC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| CFGIWNLTHG | RAQVEMQGCL | DSDEPGCESL | HCDPVPRAHP | SPSSTLFTCS | CGTDFCNANY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SHLPPSGNRG | APGPQEPQAT | PGGPIWMAQL | LLGVFLVLLL | SIIILALLQR | KACRVQGGSD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PEPEPGSGGD | CSEELPELAE | LRFSQVIQEG | GHAVVWAGRL | QGEMVAIKAF | PPRAVAQFRA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ERAVYQLLGL | QHNHIVRFIT | AGQGGPGPLP | SGPLLVLELY | PKGSLCHYLT | QYTSDWGSSL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RMALSLAEGL | AFLHGERWQD | GQYKPGIAHR | DLSSQNVLIR | EDRSCAIGDL | GLALVLPGLA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QPPALAPTQP | RGPAAILEAG | TQRYMAPELL | DKTLDLQDWG | TALQRADVYS | LALLLWEILS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RCSDLRPDHR | PPPFQLAYEA | ELGSNPSACE | LWALAVAERK | RPNIPSSWSC | SATDPRGLRE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LLEDCWDADP | EARLTAECVQ | QRLAALAYPQ | VASSFPESCP | QGCPENCPAA | PASAAFPCRP |
| 550 | |||||
| QQSSCLLSVQ | QGSGSKS |