Q95126
Gene name |
ACVR2B |
Protein name |
Activin receptor type-2B |
Names |
Activin receptor type IIB, ACTR-IIB |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:282131 |
EC number |
2.7.11.30: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
338-363 (Activation loop from InterPro)
Target domain |
190-480 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q95126
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q95126-F1 | Predicted | AlphaFoldDB |
No variants for Q95126
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q95126 | |||||
No associated diseases with Q95126
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.30 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| activin receptor complex | A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| activin binding | Binding to activin, a dimer of inhibin-beta subunits. |
| activin receptor activity | Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| metal ion binding | Binding to a metal ion. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| activin receptor signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| cellular response to growth factor stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q90999 | TGFBR2 | TGF-beta receptor type-2 | Gallus gallus (Chicken) | PR |
| Q90670 | ACVR2B | Activin receptor type-2B | Gallus gallus (Chicken) | PR |
| P37173 | TGFBR2 | TGF-beta receptor type-2 | Homo sapiens (Human) | PR |
| Q13705 | ACVR2B | Activin receptor type-2B | Homo sapiens (Human) | PR |
| Q8K592 | Amhr2 | Anti-Muellerian hormone type-2 receptor | Mus musculus (Mouse) | PR |
| Q62312 | Tgfbr2 | TGF-beta receptor type-2 | Mus musculus (Mouse) | PR |
| P27040 | Acvr2b | Activin receptor type-2B | Mus musculus (Mouse) | PR |
| Q66T47 | ACVR2B | Activin receptor type-2B | Sus scrofa (Pig) | PR |
| Q62893 | Amhr2 | Anti-Muellerian hormone type-2 receptor | Rattus norvegicus (Rat) | PR |
| P38438 | Tgfbr2 | TGF-beta receptor type-2 | Rattus norvegicus (Rat) | PR |
| P38445 | Acvr2b | Activin receptor type-2B | Rattus norvegicus (Rat) | PR |
| P50488 | daf-4 | Cell surface receptor daf-4 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTAPWAALAL | LWGSLCAGSG | RGEAETRECI | YYNANWELER | TNQSGLERCE | GERDKRLHCY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ASWRNSSGTI | ELVKKGCWLD | DFNCYDRQEC | VATEENPQVY | FCCCEGNFCN | ERFTHLPEAG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GPEVTYEPPP | TAPTLLTVLA | YSLLPVGGLS | LIALLAFWMY | RHRKPPYGHA | DIHEDPGPPP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PSPLVGLKPL | QLLEIKARGR | FGCVWKAQLM | NDFVAVKIFP | LQDKQSWQSE | REIFSTPGMK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HENLLQFIAA | EKRGSSLEAE | LWLITAFHDK | GSLTDYLKGN | IITWNELCHV | AETMSRGLSY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LHEDVPWCRG | EGHKPSIAHR | DFKSKNVLLK | SDLTAVLADF | GLAVRFEPGK | PPGDTHGQVG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TRRYMAPEVL | EGAINFQRDA | FLRIDMYAMG | LVLWELVSRC | KAADGPVDEY | MLPFEEEIGQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HPSLEELQEV | VVHKKMRPAI | KDHWLKHPGL | AQLCVTIEEC | WDHDAEARLS | AGCVEERVSL |
| 490 | 500 | 510 | |||
| IRRSVNGTTS | DCLVSLVTSV | TNVDLPPKES | SI |