Q66T47

PR
Gene name
ACVR2B
Protein name
Activin receptor type-2B
Names
Activin receptor type IIB, ACTR-IIB
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:448845
EC number
2.7.11.30: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

13-82 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

338-363 (Activation loop from InterPro)

Target domain

190-480 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q66T47

Entry ID Method Resolution Chain Position Source
AF-Q66T47-F1 Predicted AlphaFoldDB

No variants for Q66T47

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q66T47

No associated diseases with Q66T47

3 regional properties for Q66T47

Type Name Position InterPro Accession
domain Activin types I and II receptor domain 28 - 111 IPR000472
domain Protein kinase domain 190 - 480 IPR000719
active_site Serine/threonine-protein kinase, active site 317 - 329 IPR008271

Functions

Description
EC Number 2.7.11.30 Protein-serine/threonine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
activin receptor complex A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
receptor complex Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

5 GO annotations of molecular function

Name Definition
activin binding Binding to activin, a dimer of inhibin-beta subunits.
activin receptor activity Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

4 GO annotations of biological process

Name Definition
activin receptor signaling pathway The series of molecular signals initiated by an extracellular ligand binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
cellular response to growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
negative regulation of transforming growth factor beta activation Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta activation.
protein phosphorylation The process of introducing a phosphate group on to a protein.

13 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q95126 ACVR2B Activin receptor type-2B Bos taurus (Bovine) PR
Q90999 TGFBR2 TGF-beta receptor type-2 Gallus gallus (Chicken) PR
Q90670 ACVR2B Activin receptor type-2B Gallus gallus (Chicken) PR
P37173 TGFBR2 TGF-beta receptor type-2 Homo sapiens (Human) PR
Q13705 ACVR2B Activin receptor type-2B Homo sapiens (Human) PR
Q8K592 Amhr2 Anti-Muellerian hormone type-2 receptor Mus musculus (Mouse) PR
Q62312 Tgfbr2 TGF-beta receptor type-2 Mus musculus (Mouse) PR
P27040 Acvr2b Activin receptor type-2B Mus musculus (Mouse) PR
Q5CD18 TGFBR1 TGF-beta receptor type-1 Sus scrofa (Pig) PR
Q62893 Amhr2 Anti-Muellerian hormone type-2 receptor Rattus norvegicus (Rat) PR
P38438 Tgfbr2 TGF-beta receptor type-2 Rattus norvegicus (Rat) PR
P38445 Acvr2b Activin receptor type-2B Rattus norvegicus (Rat) PR
P50488 daf-4 Cell surface receptor daf-4 Caenorhabditis elegans PR
10 20 30 40 50 60
MTAPWAALAL LWGSLCVGSG RGEAETRECI YYNANWELER TNQSGLERCE GEQDKRLHCY
70 80 90 100 110 120
ASWRNSSGTI ELVKKGCWLD DFNCYDRQEC VATEENPQVY FCCCEGNFCN ERFTHLPEAG
130 140 150 160 170 180
GPEVTYEPPP TAPTLLTVLA YSLLPIGGLS LIVLLAFWMY RHRKPPYGHV DIHEDPGPPP
190 200 210 220 230 240
PSPLVGLKPL QLLEIKARGR FGCVWKAQLM NDFVAVKIFP LQDKQSWQSE REIFSTPGMK
250 260 270 280 290 300
HENLLQFIAA EKRGSNLEVE LWLITAFHDK GSLTDYLKGN IITWNELCHV AETMSRGLSY
310 320 330 340 350 360
LHEDVPWCRG EGHKPSIAHR DFKSKNVLLK SDLTAVLADF GLAVRFEPGK PPGDTHGQVG
370 380 390 400 410 420
TRRYMAPEVL EGAINFQRNA FLRIDMYAMG LVLWELVSRC KAADGPVDEY MLPFEEEIGQ
430 440 450 460 470 480
HPSLEELQEV VVHKKMRPAI KDHWLKHPGL AQLCVTIEEC WDHDAEARLS AGCVEERVSL
490 500 510
IRRSVNGTTS DCLVSLVTSV TNVDLPPKES SI