Q5CD18

PR
Gene name
TGFBR1
Protein name
TGF-beta receptor type-1
Names
TGFR-1, TGF-beta type I receptor, Transforming growth factor-beta receptor type I, TGF-beta receptor type I, TbetaR-I
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:396665
EC number
2.7.11.30: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

141-212 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

350-377 (Activation loop from InterPro)

Target domain

205-495 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q5CD18

Entry ID Method Resolution Chain Position Source
AF-Q5CD18-F1 Predicted AlphaFoldDB

2 variants for Q5CD18

Variant ID(s) Position Change Description Diseaes Association Provenance
8 P>S No
417 I>V No

No associated diseases with Q5CD18

8 regional properties for Q5CD18

Type Name Position InterPro Accession
domain THIF-type NAD/FAD binding fold 54 - 444 IPR000594-1
domain THIF-type NAD/FAD binding fold 450 - 945 IPR000594-2
conserved_site Ubiquitin-activating enzyme E1, conserved site 410 - 418 IPR018074
domain Ubiquitin-activating enzyme E1, C-terminal 922 - 1053 IPR018965
domain Ubiquitin-activating enzyme, SCCH domain 637 - 884 IPR019572
domain Ubiquitin-activating enzyme E1, FCCH domain 226 - 295 IPR032418
domain Ubiquitin-activating enzyme E1, four-helix bundle 297 - 365 IPR032420
active_site Ubiquitin-activating enzyme E1, Cys active site 629 - 637 IPR033127

Functions

Description
EC Number 2.7.11.30 Protein-serine/threonine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • Cell junction, tight junction
  • Membrane raft
  • Cell surface
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
activin receptor complex A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed.
bicellular tight junction An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
cell surface The external part of the cell wall and/or plasma membrane.
endosome A vacuole to which materials ingested by endocytosis are delivered.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
membrane raft Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
receptor complex Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

8 GO annotations of molecular function

Name Definition
activin binding Binding to activin, a dimer of inhibin-beta subunits.
activin receptor activity, type I Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
SMAD binding Binding to a SMAD signaling protein.
transforming growth factor beta binding Binding to TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types.
transforming growth factor beta receptor activity, type I Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals.

16 GO annotations of biological process

Name Definition
activin receptor signaling pathway The series of molecular signals initiated by an extracellular ligand binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
cardiac epithelial to mesenchymal transition A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
cellular response to growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
endothelial cell activation The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
heart development The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
mesenchymal cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of endothelial cell proliferation Any process that activates or increases the rate or extent of endothelial cell proliferation.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of epithelial to mesenchymal transition Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
transforming growth factor beta receptor signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8NER5 ACVR1C Activin receptor type-1C Homo sapiens (Human) PR
P36897 TGFBR1 TGF-beta receptor type-1 Homo sapiens (Human) PR
Q61288 Acvrl1 Serine/threonine-protein kinase receptor R3 Mus musculus (Mouse) PR
Q8K348 Acvr1c Activin receptor type-1C Mus musculus (Mouse) PR
Q64729 Tgfbr1 TGF-beta receptor type-1 Mus musculus (Mouse) PR
Q66T47 ACVR2B Activin receptor type-2B Sus scrofa (Pig) PR
P80201 Acvr1 Activin receptor type-1 Rattus norvegicus (Rat) PR
P70539 Acvr1c Activin receptor type-1C Rattus norvegicus (Rat) PR
P20792 daf-1 Cell surface receptor daf-1 Caenorhabditis elegans PR
10 20 30 40 50 60
MEVAAGAPRS RLLLFVLAAT ATLAPEATAF QCFCHLCTKD NFTCVTDGLC FVSVTETTDK
70 80 90 100 110 120
VIHNSMCIAE IDLIPRDRPF VCAPSSKTGS VTTTYCCNQD HCNKIELPTV GPFPGKPPSG
130 140 150 160 170 180
LGPVELAAVI AGPVCFVCIS LMLMVYICHN RTVIHHRVPN EEDPSLDRPF ISEGTTLKDL
190 200 210 220 230 240
IYDMTTSGSG SGLPLLVQRT IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER
250 260 270 280 290 300
SWFREAEIYQ TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE
310 320 330 340 350 360
GMIKLALSTA SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA DLGLAVRHDS
370 380 390 400 410 420
ATDTIDIAPN HRVGTKRYMA PEVLDDSINM KHFESFKRAD IYAMGLVFWE IARRCSIGGI
430 440 450 460 470 480
HEDYQLPYYD LVPSDPSVEE MRKVVCEQKL RPNIPNRWQS CEALRVMAKI MRECWYANGA
490 500
ARLTALRIKK TLSQLSQQEG IKM