P20792

PR
Gene name
daf-1 (F29C4.1)
Protein name
Cell surface receptor daf-1
Names
Abnormal dauer formation protein 1
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_F29C4.1
EC number
2.7.11.30: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

178-313 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

440-468 (Activation loop from InterPro)

Target domain

293-594 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P20792

Entry ID Method Resolution Chain Position Source
AF-P20792-F1 Predicted AlphaFoldDB

No variants for P20792

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P20792

No associated diseases with P20792

5 regional properties for P20792

Type Name Position InterPro Accession
domain PLAT/LH2 domain 10 - 164 IPR001024
domain Lipoxygenase, C-terminal 166 - 857 IPR013819
binding_site Lipoxygenase, iron binding site 513 - 527 IPR020833
conserved_site Lipoxygenase, conserved site 540 - 550 IPR020834
domain Plant lipoxygenase, PLAT/LH2 domain 10 - 164 IPR042057

Functions

Description
EC Number 2.7.11.30 Protein-serine/threonine kinases
Subcellular Localization
  • Membrane; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
activin receptor complex A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
receptor complex Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

5 GO annotations of molecular function

Name Definition
activin binding Binding to activin, a dimer of inhibin-beta subunits.
activin receptor activity, type I Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
transforming growth factor beta receptor activity Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

16 GO annotations of biological process

Name Definition
activin receptor signaling pathway The series of molecular signals initiated by an extracellular ligand binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
cellular response to growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
dauer entry Entry into the facultative diapause of the dauer (enduring) larval stage of nematode development.
dauer larval development The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding.
defense response to Gram-negative bacterium Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
detection of bacterium The series of events in which a stimulus from a bacterium is received and converted into a molecular signal.
determination of adult lifespan The pathways that regulate the duration of the adult phase of the life-cycle of an animal.
larval feeding behavior Feeding behavior in a larval (immature) organism.
negative regulation of dauer larval development Any process that decreases the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding.
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of dauer larval development Any process that modulates the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding.
regulation of eating behavior Any process that modulates the frequency, rate or extent of eating behavior.
regulation of pharyngeal pumping Any process that modulates the contraction and relaxation movements of the pharyngeal muscle that mediates feeding in nematodes.
transforming growth factor beta receptor signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8NER5 ACVR1C Activin receptor type-1C Homo sapiens (Human) PR
P36897 TGFBR1 TGF-beta receptor type-1 Homo sapiens (Human) PR
Q61288 Acvrl1 Serine/threonine-protein kinase receptor R3 Mus musculus (Mouse) PR
Q8K348 Acvr1c Activin receptor type-1C Mus musculus (Mouse) PR
Q64729 Tgfbr1 TGF-beta receptor type-1 Mus musculus (Mouse) PR
Q5CD18 TGFBR1 TGF-beta receptor type-1 Sus scrofa (Pig) PR
P80201 Acvr1 Activin receptor type-1 Rattus norvegicus (Rat) PR
P70539 Acvr1c Activin receptor type-1C Rattus norvegicus (Rat) PR
P50488 daf-4 Cell surface receptor daf-4 Caenorhabditis elegans PR
10 20 30 40 50 60
MRIRHVVFCL LALVYGAETS DDDLDERTNI FIRDKLIPAL KLAEVTKVNF TRLHLCHCSR
70 80 90 100 110 120
EVGCNARTTG WVPGIEFLNE TDRSFYENTC YTDGSCYQSA RPSPEISHFG CMDEKSVTDE
130 140 150 160 170 180
TEFHDTAAKV CTNNTKDPHA TVWICCDKGN FCANETIIHL APGPQQSSTW LILTILALLT
190 200 210 220 230 240
FIVLLGIAIF LTRKSWEAKF DWYIRFKPKP GDPLRETENN VPMVTMGDGA GSSVPEVAPI
250 260 270 280 290 300
EQQGSTMSTS AGNSFPPGIM PNNMKDMLDV LEETSGSGMG PTTLHKLTIG GQIRLTGRVG
310 320 330 340 350 360
SGRFGNVSRG DYRGEAVAVK VFNALDEPAF HKETEIFETR MLRHPNVLRY IGSDRVDTGF
370 380 390 400 410 420
VTELWLVTEY HPSGSLHDFL LENTVNIETY YNLMRSTASG LAFLHNQIGG SKESNKPAMA
430 440 450 460 470 480
HRDIKSKNIM VKNDLTCAIG DLGLSLSKPE DAASDIIANE NYKCGTVRYL APEILNSTMQ
490 500 510 520 530 540
FTVFESYQCA DVYSFSLVMW ETLCRCEDGD VLPREAATVI PYIEWTDRDP QDAQMFDVVC
550 560 570 580 590 600
TRRLRPTENP LWKDHPEMKH IMEIIKTCWN GNPSARFTSY ICRKRMDERQ QLLLDKKAKA
610 620 630 640 650 660
VAQTAGVTVQ DRKILGPQKP KDESPANGAP RIVQKEIDRE DEQENWRETA KTPNGHISSN
DDSSRPLLG