P50488
PR
Gene name |
daf-4 |
Protein name |
Cell surface receptor daf-4 |
Names |
Abnormal dauer formation protein 4 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_C05D2.1 |
EC number |
2.7.11.30: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P50488
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P50488-F1 | Predicted | AlphaFoldDB |
No variants for P50488
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P50488 | |||||
No associated diseases with P50488
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.30 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| activin receptor complex | A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| activin binding | Binding to activin, a dimer of inhibin-beta subunits. |
| activin receptor activity | Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| BMP binding | Binding to a member of the bone morphogenetic protein (BMP) family. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| transmembrane receptor protein serine/threonine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
22 GO annotations of biological process
| Name | Definition |
|---|---|
| activin receptor signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| BMP signaling pathway | The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| cellular response to growth factor stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. |
| dauer entry | Entry into the facultative diapause of the dauer (enduring) larval stage of nematode development. |
| dauer larval development | The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding. |
| defense response to fungus | Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. |
| determination of adult lifespan | The pathways that regulate the duration of the adult phase of the life-cycle of an animal. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| larval feeding behavior | Feeding behavior in a larval (immature) organism. |
| negative regulation of BMP signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway. |
| negative regulation of dauer larval development | Any process that decreases the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding. |
| nematode larval development | The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. |
| oviposition | The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water. |
| positive regulation of BMP signaling pathway | Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity. |
| positive regulation of multicellular organism growth | Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size. |
| positive regulation of nematode male tail tip morphogenesis | Any process that activates or increases the frequency, rate or extent of nematode male tail tip morphogenesis. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of cell morphogenesis | Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized. |
| regulation of dauer larval development | Any process that modulates the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding. |
| regulation of eating behavior | Any process that modulates the frequency, rate or extent of eating behavior. |
| regulation of mesodermal cell fate specification | Any process that modulates the frequency, rate or extent of mesoderm cell fate specification. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q95126 | ACVR2B | Activin receptor type-2B | Bos taurus (Bovine) | PR |
| Q90670 | ACVR2B | Activin receptor type-2B | Gallus gallus (Chicken) | PR |
| Q90999 | TGFBR2 | TGF-beta receptor type-2 | Gallus gallus (Chicken) | PR |
| P37173 | TGFBR2 | TGF-beta receptor type-2 | Homo sapiens (Human) | PR |
| Q13705 | ACVR2B | Activin receptor type-2B | Homo sapiens (Human) | PR |
| Q8K592 | Amhr2 | Anti-Muellerian hormone type-2 receptor | Mus musculus (Mouse) | PR |
| P27040 | Acvr2b | Activin receptor type-2B | Mus musculus (Mouse) | PR |
| Q62312 | Tgfbr2 | TGF-beta receptor type-2 | Mus musculus (Mouse) | PR |
| Q66T47 | ACVR2B | Activin receptor type-2B | Sus scrofa (Pig) | PR |
| Q62893 | Amhr2 | Anti-Muellerian hormone type-2 receptor | Rattus norvegicus (Rat) | PR |
| P38445 | Acvr2b | Activin receptor type-2B | Rattus norvegicus (Rat) | PR |
| P38438 | Tgfbr2 | TGF-beta receptor type-2 | Rattus norvegicus (Rat) | PR |
| P20792 | daf-1 | Cell surface receptor daf-1 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNQKGTVRLK | ALVLICLPLF | LIATPVPVAV | TEDDRQDRIE | SEAAEKEWAN | TLVSKVAQSN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GTGTIKVSAP | AKPTLRRMDN | EEDEVISIEC | VYYDEMECEK | SGDCEITKKT | CYSEAHLKAV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GCLAVFGLPT | QEINSTEPYL | KVDKPQYKSL | GCMPYQHADS | MNCENESSCR | QGRSFRGGIG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MCCCSTNNCN | MPDLIEMVNP | SLKKDSDNSA | LLWASTPSNM | DLESLDKFPF | YWIIIIALSV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ILCIALLILA | YVGWKFQQNK | KEEIKKQQKI | KFDMEKTDAL | EAGNVPLVEP | EEEMIEMVET |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PKELPITDFQ | LISKGRFGKV | FKAQYTPDSG | EKRLVAVKKL | NEFQKASFLA | EKRIFDELNE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YPKWYKSIVE | FVCAEKIGDE | YWIVTEFHER | LSLYELLKNN | VISITSANRI | IMSMIDGLQF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LHDDRPYFFG | HPKKPIIHRD | IKSKNILVKS | DMTTCIADFG | LARIYSYDIE | QSDLLGQVGT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KRYMSPEMLE | GATEFTPTAF | KAMDVYSMGL | VMWEVISRTK | LHQTDEPPNY | QMPFQVIGFD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PTIGLMRNYV | VSKKERPQWR | DEIIKHEYMS | LLKKVTEEMW | DPEACARITA | GCAFARVWNH |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IMSSPDSSEG | YHSGSSMKNR | GVDDVEQSEK | PEGIEEMQHY | HASSPSKRQH | PSPNPFFDSC |
| 670 | 680 | 690 | 700 | 710 | 720 |
| PPPPPIPVIL | ENGGILQPDN | AEPEPEELPD | LPIVEKIYDI | ATNMLFSREE | LDLMNAQRQV |
| 730 | 740 | ||||
| EYEAGADTRA | STPTPSGTFG | TFTT |