AiPD: Autoinhibited Protein Database

Gene name	ACVR2B
Protein name	Activin receptor type-2B
Names	Activin receptor type IIB, ACTR-IIB
Species	Gallus gallus (Chicken)
KEGG Pathway	gga:374213
EC number	2.7.11.30: Protein-serine/threonine kinases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-84 (Predicted disordered autoinhibitory region) PR

1-84 (Predicted disordered autoinhibitory region)

cis-regPred

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q90670-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs316598051	21	H>R	No	Ensembl
rs733128165	44	S>R	No	Ensembl
rs736436281	49	C>G	No	Ensembl
rs735813371	52	E>G	No	Ensembl
rs732268432	54	D>E	No	Ensembl
rs737076002	58	H>P	No	Ensembl
rs731675143	89	E>G	No	Ensembl
rs734340630	90	C>G	No	Ensembl
rs1059349079	104	C>Y	No	Ensembl
rs736719517	164	K>Q	No	Ensembl
rs1060020864	198	R>K	No	Ensembl
rs317408255	249	A>E	No	Ensembl
rs315170077	250	A>E	No	Ensembl
rs740424615	300	Y>F	No	Ensembl
rs732189460	336	V>G	No	Ensembl
rs741067092	337	L>V	No	Ensembl
rs317920401	343	A>S	No	Ensembl
rs1058789126	430	V>A	No	Ensembl
rs741593795	451	A>V	No	Ensembl
rs731852548	458	E>A	No	Ensembl
rs1057696155	464	D>G	No	Ensembl
rs312854816	476	E>G	No	Ensembl
rs15874998	488	T>S	No	Ensembl

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q90670

		Description
EC Number	2.7.11.30	Protein-serine/threonine kinases
Subcellular Localization	Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
basal part of cell	The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Name	Definition
activin binding	Binding to activin, a dimer of inhibin-beta subunits.
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding	Binding to a metal ion.
transmembrane receptor protein serine/threonine kinase activity	Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

Name	Definition
activin receptor signaling pathway	The series of molecular signals initiated by an extracellular ligand binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
axis specification	The establishment, maintenance and elaboration of a pattern along a line or around a point.
cell population proliferation	The multiplication or reproduction of cells, resulting in the expansion of a cell population.
cranial ganglion development	The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure.
mesodermal cell differentiation	The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell.
negative regulation of transforming growth factor beta activation	Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta activation.
positive regulation of neuron apoptotic process	Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
protein phosphorylation	The process of introducing a phosphate group on to a protein.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q95126	ACVR2B	Activin receptor type-2B	Bos taurus (Bovine)	PR
Q90999	TGFBR2	TGF-beta receptor type-2	Gallus gallus (Chicken)	PR
P37173	TGFBR2	TGF-beta receptor type-2	Homo sapiens (Human)	PR
Q13705	ACVR2B	Activin receptor type-2B	Homo sapiens (Human)	PR
Q8K592	Amhr2	Anti-Muellerian hormone type-2 receptor	Mus musculus (Mouse)	PR
Q62312	Tgfbr2	TGF-beta receptor type-2	Mus musculus (Mouse)	PR
P27040	Acvr2b	Activin receptor type-2B	Mus musculus (Mouse)	PR
Q66T47	ACVR2B	Activin receptor type-2B	Sus scrofa (Pig)	PR
Q62893	Amhr2	Anti-Muellerian hormone type-2 receptor	Rattus norvegicus (Rat)	PR
P38438	Tgfbr2	TGF-beta receptor type-2	Rattus norvegicus (Rat)	PR
P38445	Acvr2b	Activin receptor type-2B	Rattus norvegicus (Rat)	PR
P50488	daf-4	Cell surface receptor daf-4	Caenorhabditis elegans	PR