Q61598
PR
Gene name |
Gdi2 (Gdi3) |
Protein name |
Rab GDP dissociation inhibitor beta |
Names |
Rab GDI beta, GDI-3, Guanosine diphosphate dissociation inhibitor 2, GDI-2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:14569 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q61598
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q61598-F1 | Predicted | AlphaFoldDB |
18 variants for Q61598
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389258894 | 19 | L>P | No | EVA | |
| rs3389269149 | 22 | I>V | No | EVA | |
| rs3389240312 | 34 | D>V | No | EVA | |
| rs3389265965 | 47 | T>K | No | EVA | |
| rs3389252409 | 61 | Q>P | No | EVA | |
| rs3389225541 | 66 | M>V | No | EVA | |
| rs3389197493 | 187 | H>Y | No | EVA | |
| rs3389282227 | 215 | S>Y | No | EVA | |
| rs3389268918 | 221 | K>R | No | EVA | |
| rs3389265622 | 258 | I>F | No | EVA | |
| rs3389277529 | 276 | R>H | No | EVA | |
| rs3389240268 | 294 | V>M | No | EVA | |
| rs3403404443 | 322 | P>R | No | EVA | |
| rs3389197471 | 330 | S>P | No | EVA | |
| rs3389225488 | 357 | V>M | No | EVA | |
| rs3389275705 | 410 | F>S | No | EVA | |
| rs3389240313 | 423 | R>K | No | EVA | |
| rs3389263114 | 437 | K>Q | No | EVA |
No associated diseases with Q61598
No regional properties for Q61598
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q61598 | |||
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| myelin sheath | An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| Rab GDP-dissociation inhibitor activity | Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding. |
| small GTPase binding | Binding to a small monomeric GTPase. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of cilium assembly | Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly. |
| negative regulation of protein localization to cilium | Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| small GTPase mediated signal transduction | The series of molecular signals in which a small monomeric GTPase relays a signal. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P39958 | GDI1 | Rab GDP-dissociation inhibitor | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P21856 | GDI1 | Rab GDP dissociation inhibitor alpha | Bos taurus (Bovine) | PR |
| P50397 | GDI2 | Rab GDP dissociation inhibitor beta | Bos taurus (Bovine) | PR |
| P60028 | GDI1 | Rab GDP dissociation inhibitor alpha | Pan troglodytes (Chimpanzee) | PR |
| O97556 | GDI2 | Rab GDP dissociation inhibitor beta | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| P31150 | GDI1 | Rab GDP dissociation inhibitor alpha | Homo sapiens (Human) | PR |
| P50395 | GDI2 | Rab GDP dissociation inhibitor beta | Homo sapiens (Human) | PR |
| P50396 | Gdi1 | Rab GDP dissociation inhibitor alpha | Mus musculus (Mouse) | PR |
| Q9QZD5 | Chml | Rab proteins geranylgeranyltransferase component A 2 | Mus musculus (Mouse) | PR |
| P50398 | Gdi1 | Rab GDP dissociation inhibitor alpha | Rattus norvegicus (Rat) | PR |
| P50399 | Gdi2 | Rab GDP dissociation inhibitor beta | Rattus norvegicus (Rat) | PR |
| Q9LXC0 | At5g09550 | Guanosine nucleotide diphosphate dissociation inhibitor At5g09550 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O24653 | GDI2 | Guanosine nucleotide diphosphate dissociation inhibitor 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q96254 | GDI1 | Guanosine nucleotide diphosphate dissociation inhibitor 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNEEYDVIVL | GTGLTECILS | GIMSVNGKKV | LHMDQNPYYG | GESASITPLE | DLYKRFKLPG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QPPASMGRGR | DWNVDLIPKF | LMANGQLVKM | LLFTEVTRYM | DFKVIEGSFV | YKGGKIYKVP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| STEAEALASS | LMGLFEKRRF | RKFLVYVANF | DEKDPRTFEG | VDPKKTSMRD | VYKKFDLGQD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VIDFTGHSLA | LYRTDDYLDQ | PCCETINRIK | LYSESLARYG | KSPYLYPLYG | LGELPQGFAR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LSAIYGGTYM | LNKPIEEIIV | QNGKVVGVKS | EGEIARCKQL | ICDPSYVKDR | VEKVGQVIRV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ICILSHPIKN | TNDANSCQII | IPQNQVNRKS | DIYVCMISFA | HNVAAQGKYI | AIVSTTVETK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EPEKEIRPAL | ELLEPIEQKF | VSISDLFVPK | DLGTDSQIFI | SRAYDATTHF | ETTCDDIKDI |
| 430 | 440 | ||||
| YKRMTGSEFD | FEEMKRKKND | IYGED |