O97556

PR
Gene name
GDI2
Protein name
Rab GDP dissociation inhibitor beta
Names
Rab GDI beta, Guanosine diphosphate dissociation inhibitor 2, GDI-2
Species
Canis lupus familiaris (Dog) (Canis familiaris)
KEGG Pathway
cfa:403818
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

20-91 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O97556

Entry ID Method Resolution Chain Position Source
AF-O97556-F1 Predicted AlphaFoldDB

No variants for O97556

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O97556

No associated diseases with O97556

No regional properties for O97556

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O97556

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

2 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
Rab GDP-dissociation inhibitor activity Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding.

5 GO annotations of biological process

Name Definition
negative regulation of cilium assembly Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly.
negative regulation of protein localization to cilium Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
small GTPase mediated signal transduction The series of molecular signals in which a small monomeric GTPase relays a signal.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P39958 GDI1 Rab GDP-dissociation inhibitor Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P50397 GDI2 Rab GDP dissociation inhibitor beta Bos taurus (Bovine) PR
O97555 GDI1 Rab GDP dissociation inhibitor alpha Canis lupus familiaris (Dog) (Canis familiaris) PR
P50395 GDI2 Rab GDP dissociation inhibitor beta Homo sapiens (Human) PR
Q61598 Gdi2 Rab GDP dissociation inhibitor beta Mus musculus (Mouse) PR
P50399 Gdi2 Rab GDP dissociation inhibitor beta Rattus norvegicus (Rat) PR
O24653 GDI2 Guanosine nucleotide diphosphate dissociation inhibitor 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LXC0 At5g09550 Guanosine nucleotide diphosphate dissociation inhibitor At5g09550 Arabidopsis thaliana (Mouse-ear cress) PR
Q96254 GDI1 Guanosine nucleotide diphosphate dissociation inhibitor 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MNEEYDVIVL GTGLTECILS GIMTVNGKKV LHMDRNPYYG GESASITPLE DLYKRFKIPG
70 80 90 100 110 120
APPASMGRGR DWNLDLIPKF LMANGQLVKM LLYTEVTRYL DFKVTEGSFV YKGGKIYKVP
130 140 150 160 170 180
STEAEALASS LMGLFEKRRF RKFLVYVANF DEKDPRTFEG IDPKKTAIGE VYKKFDLGQD
190 200 210 220 230 240
VIDFTGHALA LYRTDDYLDQ PCCETINRIK LYSESLARYG KSPYLYPLYG LGELPQGFAR
250 260 270 280 290 300
LSAIYGGTYM LNKPIEEIIV QNGKVIGVKS EGEVARCKQL ICDPSYVKDR VEKVGQVIRV
310 320 330 340 350 360
ICILSHPIKN TNDANSCQII IPQNQVNRKS DIYVCMISSA HNVAAQGKYI AIVSTTAETK
370 380 390 400 410 420
EPEKEIRPAL ELLEPIEQKF VSISDLLVPK DLGTESQIFI SRTYDATTHF ETTCDDIKNI
430 440
YKRMTGSEFD FEEMKRKKND IYGED