Q96254
Gene name |
GDI1 (At2g44100, F6E13.23) |
Protein name |
Guanosine nucleotide diphosphate dissociation inhibitor 1 |
Names |
AtGDI1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G44100 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q96254
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q96254-F1 | Predicted | AlphaFoldDB |
17 variants for Q96254
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_2_18242427_G_T | 63 | A>S | No | 1000Genomes | |
| ENSVATH14613635 | 63 | A>V | No | 1000Genomes | |
| tmp_2_18242432_T_A | 64 | H>Q | No | 1000Genomes | |
| tmp_2_18242569_G_T | 80 | M>I | No | 1000Genomes | |
| tmp_2_18242951_A_T | 145 | Y>F | No | 1000Genomes | |
| tmp_2_18243010_G_A | 165 | V>I | No | 1000Genomes | |
| ENSVATH05714133 | 166 | T>K | No | 1000Genomes | |
| tmp_2_18243134_G_A | 175 | G>D | No | 1000Genomes | |
| tmp_2_18243528_G_T | 237 | A>S | No | 1000Genomes | |
| tmp_2_18243720_G_A | 262 | E>K | No | 1000Genomes | |
| tmp_2_18243752_G_C | 272 | E>D | No | 1000Genomes | |
| ENSVATH13633402 | 278 | C>S | No | 1000Genomes | |
| ENSVATH05714143 | 345 | A>T | No | 1000Genomes | |
| ENSVATH13633404 | 389 | E>G | No | 1000Genomes | |
| ENSVATH05714145 | 402 | S>T | No | 1000Genomes | |
| tmp_2_18244706_T_C | 424 | L>S | No | 1000Genomes | |
| ENSVATH05714149 | 433 | S>T | No | 1000Genomes |
No associated diseases with Q96254
No regional properties for Q96254
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q96254 | |||
2 GO annotations of cellular component
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| Rab GDP-dissociation inhibitor activity | Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| small GTPase mediated signal transduction | The series of molecular signals in which a small monomeric GTPase relays a signal. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P39958 | GDI1 | Rab GDP-dissociation inhibitor | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P21856 | GDI1 | Rab GDP dissociation inhibitor alpha | Bos taurus (Bovine) | PR |
| P50397 | GDI2 | Rab GDP dissociation inhibitor beta | Bos taurus (Bovine) | PR |
| P60028 | GDI1 | Rab GDP dissociation inhibitor alpha | Pan troglodytes (Chimpanzee) | PR |
| O97555 | GDI1 | Rab GDP dissociation inhibitor alpha | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| O97556 | GDI2 | Rab GDP dissociation inhibitor beta | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| P31150 | GDI1 | Rab GDP dissociation inhibitor alpha | Homo sapiens (Human) | PR |
| P50395 | GDI2 | Rab GDP dissociation inhibitor beta | Homo sapiens (Human) | PR |
| P50396 | Gdi1 | Rab GDP dissociation inhibitor alpha | Mus musculus (Mouse) | PR |
| Q61598 | Gdi2 | Rab GDP dissociation inhibitor beta | Mus musculus (Mouse) | PR |
| P50398 | Gdi1 | Rab GDP dissociation inhibitor alpha | Rattus norvegicus (Rat) | PR |
| P50399 | Gdi2 | Rab GDP dissociation inhibitor beta | Rattus norvegicus (Rat) | PR |
| O24653 | GDI2 | Guanosine nucleotide diphosphate dissociation inhibitor 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LXC0 | At5g09550 | Guanosine nucleotide diphosphate dissociation inhibitor At5g09550 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDEEYEVIVL | GTGLKECILS | GLLSVDGLKV | LHMDRNDYYG | GESTSLNLNQ | LWKKFRGEEK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| APAHLGSSRD | YNVDMMPKFM | MANGKLVRVL | IHTDVTKYLS | FKAVDGSYVF | VQGKVQKVPA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TPMEALKSPL | MGIFEKRRAG | KFFSYVQEYD | EKDPKTHDGM | DLRRVTTKDL | IAKFGLKEDT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IDFIGHAVAL | HCNDNHLHQP | AYDTVMRMKL | YAESLARFQG | GSPYIYPLYG | LGELPQAFAR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LSAVYGGTYM | LNKPECKVEF | DEEGKVSGVT | SEGETAKCKK | VVCDPSYLTN | KVRKIGRVAR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AIAIMSHPIP | NTNDSQSVQV | ILPQKQLGRK | SDMYVFCCSY | SHNVAPKGKF | IAFVSTDAET |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DNPQTELQPG | IDLLGPVDEL | FFDIYDRYEP | VNEPTLDNCF | ISTSYDATTH | FDTTVVDVLN |
| 430 | 440 | ||||
| MYKLITGKEL | DLSVDLNAAS | AAEEE |