P21856
PR
Gene name |
GDI1 (RABGDIA) |
Protein name |
Rab GDP dissociation inhibitor alpha |
Names |
Lyb-2, Lyb-2, Lymphocyte antigen 32, Ly-32, Rab GDI alpha, Guanosine diphosphate dissociation inhibitor 1, GDI-1, SMG p25A GDI |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:281188 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for P21856
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1D5T | X-ray | 104 A | A | 1-431 | PDB |
| 1GND | X-ray | 181 A | A | 1-447 | PDB |
| 1LV0 | X-ray | 200 A | A | 1-447 | PDB |
| AF-P21856-F1 | Predicted | AlphaFoldDB |
190 variants for P21856
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs444039192 | 2 | D>A | No | EVA | |
| rs457858818 | 2 | D>E | No | EVA | |
| rs444039192 | 2 | D>G | No | EVA | |
| rs475439084 | 2 | D>Y | No | EVA | |
| rs471459345 | 3 | E>A | No | EVA | |
| rs471459345 | 3 | E>G | No | EVA | |
| rs460323714 | 4 | E>D | No | EVA | |
| rs440055404 | 4 | E>G | No | EVA | |
| rs480402720 | 5 | Y>C | No | EVA | |
| rs462677705 | 6 | D>A | No | EVA | |
| rs462677705 | 6 | D>G | No | EVA | |
| rs449109904 | 6 | D>H | No | EVA | |
| rs450779205 | 7 | V>E | No | EVA | |
| rs450779205 | 7 | V>G | No | EVA | |
| rs482073499 | 7 | V>L | No | EVA | |
| rs482073499 | 7 | V>M | No | EVA | |
| rs464527650 | 8 | I>V | No | EVA | |
| rs467144543 | 9 | V>G | No | EVA | |
| rs446890671 | 9 | V>M | No | EVA | |
| rs456075810 | 10 | L>P | No | EVA | |
| rs435775872 | 10 | L>V | No | EVA | |
| rs476080085 | 12 | T>P | No | EVA | |
| rs471376724 | 15 | T>P | No | EVA | |
| rs471376724 | 15 | T>S | No | EVA | |
| rs432205444 | 17 | C>W | No | EVA | |
| rs452295353 | 18 | I>L | No | EVA | |
| rs434682952 | 24 | S>T | No | EVA | |
| rs454782509 | 25 | V>A | No | EVA | |
| rs474236500 | 28 | K>R | No | EVA | |
| rs442842382 | 35 | R>W | No | EVA | |
| rs463083279 | 36 | N>K | No | EVA | |
| rs476690636 | 39 | Y>D | No | EVA | |
| rs438852194 | 44 | S>F | No | EVA | |
| rs459145757 | 47 | T>P | No | EVA | |
| rs474961238 | 54 | K>E | No | EVA | |
| rs443907210 | 54 | K>R | No | EVA | |
| rs477086923 | 57 | Q>R | No | EVA | |
| rs439163062 | 59 | L>M | No | EVA | |
| rs479573028 | 65 | T>K | No | EVA | |
| rs482004644 | 67 | G>A | No | EVA | |
| rs482004644 | 67 | G>D | No | EVA | |
| rs468376036 | 67 | G>S | No | EVA | |
| rs432389758 | 71 | D>E | No | EVA | |
| rs876577006 | 71 | D>G | No | EVA | |
| rs466154677 | 74 | V>D | No | EVA | |
| rs446010596 | 74 | V>L | No | EVA | |
| rs434852296 | 76 | L>S | No | EVA | |
| rs437356009 | 78 | P>H | No | EVA | |
| rs475049115 | 78 | P>T | No | EVA | |
| rs457669918 | 82 | M>V | No | EVA | |
| rs479645248 | 87 | L>V | No | EVA | |
| rs468375139 | 88 | V>G | No | EVA | |
| rs448376577 | 88 | V>L | No | EVA | |
| rs482147522 | 96 | V>G | No | EVA | |
| rs450925942 | 98 | R>H | No | EVA | |
| rs464736538 | 102 | F>V | No | EVA | |
| rs453565976 | 103 | K>M | No | EVA | |
| rs433362369 | 103 | K>Q | No | EVA | |
| rs455348141 | 106 | E>Q | No | EVA | |
| rs475350893 | 113 | G>V | No | EVA | |
| rs444100985 | 114 | G>A | No | EVA | |
| rs471621098 | 123 | E>G | No | EVA | |
| rs440167188 | 124 | T>A | No | EVA | |
| rs460311728 | 124 | T>I | No | EVA | |
| rs442651555 | 126 | A>T | No | EVA | |
| rs482232122 | 127 | L>W | No | EVA | |
| rs478480755 | 128 | A>D | No | EVA | |
| rs464640103 | 128 | A>T | No | EVA | |
| rs447079791 | 129 | S>P | No | EVA | |
| rs435878599 | 130 | N>D | No | EVA | |
| rs461338506 | 132 | M>I | No | EVA | |
| rs434692275 | 132 | M>L | No | EVA | |
| rs454786853 | 135 | F>I | No | EVA | |
| rs454786853 | 135 | F>L | No | EVA | |
| rs454786853 | 135 | F>V | No | EVA | |
| rs467803159 | 135 | F>Y | No | EVA | |
| rs456662284 | 136 | E>D | No | EVA | |
| rs476718905 | 138 | R>P | No | EVA | |
| rs438843231 | 139 | R>G | No | EVA | |
| rs452614177 | 140 | F>L | No | EVA | |
| rs472574045 | 142 | K>T | No | EVA | |
| rs443188301 | 145 | V>G | No | EVA | |
| rs474456401 | 145 | V>M | No | EVA | |
| rs463323835 | 147 | V>L | No | EVA | |
| rs445695428 | 149 | N>H | No | EVA | |
| rs459555675 | 151 | D>N | No | EVA | |
| rs448417541 | 153 | N>K | No | EVA | |
| rs479589919 | 153 | N>S | No | EVA | |
| rs436430313 | 154 | D>A | No | EVA | |
| rs468465766 | 154 | D>Y | No | EVA | |
| rs450010030 | 155 | P>T | No | EVA | |
| rs470173345 | 166 | T>S | No | EVA | |
| rs432493662 | 167 | S>R | No | EVA | |
| rs452475106 | 172 | Y>* | No | EVA | |
| rs472635707 | 173 | R>L | No | EVA | |
| rs434950076 | 174 | K>Q | No | EVA | |
| rs455114595 | 175 | F>I | No | EVA | |
| rs457608252 | 196 | D>E | No | EVA | |
| rs470571412 | 196 | D>N | No | EVA | |
| rs464854538 | 197 | Y>H | No | EVA | |
| rs433415539 | 197 | Y>S | No | EVA | |
| rs452929135 | 198 | L>R | No | EVA | |
| rs446470754 | 199 | D>A | No | EVA | |
| rs446470754 | 199 | D>G | No | EVA | |
| rs472960322 | 199 | D>H | No | EVA | |
| rs455403687 | 200 | Q>K | No | EVA | |
| rs475657630 | 201 | P>S | No | EVA | |
| rs444211992 | 202 | C>W | No | EVA | |
| rs477911897 | 204 | E>D | No | EVA | |
| rs457826688 | 204 | E>G | No | EVA | |
| rs440235999 | 205 | T>A | No | EVA | |
| rs440235999 | 205 | T>S | No | EVA | |
| rs479600308 | 206 | I>L | No | EVA | |
| rs448512615 | 206 | I>N | No | EVA | |
| rs482519204 | 207 | N>K | No | EVA | |
| rs468693747 | 207 | N>T | No | EVA | |
| rs451084961 | 209 | I>T | No | EVA | |
| rs464675099 | 210 | K>R | No | EVA | |
| rs433479036 | 213 | S>N | No | EVA | |
| rs453616071 | 215 | S>P | No | EVA | |
| rs453616071 | 215 | S>T | No | EVA | |
| rs466600511 | 216 | L>Q | No | EVA | |
| rs435176613 | 219 | Y>H | No | EVA | |
| rs455391699 | 221 | K>T | No | EVA | |
| rs475556239 | 226 | Y>C | No | EVA | |
| rs475556239 | 226 | Y>F | No | EVA | |
| rs437639493 | 228 | L>I | No | EVA | |
| rs440508739 | 242 | S>R | No | EVA | |
| rs460758341 | 265 | V>A | No | EVA | |
| rs480861190 | 266 | V>E | No | EVA | |
| rs472715016 | 274 | V>A | No | EVA | |
| rs441477914 | 276 | R>L | No | EVA | |
| rs525835245 | 282 | C>* | No | EVA | |
| rs443327188 | 283 | D>A | No | EVA | |
| rs463463541 | 283 | D>E | No | EVA | |
| rs477239221 | 285 | S>N | No | EVA | |
| rs439435890 | 291 | V>E | No | EVA | |
| rs459494716 | 297 | V>F | No | EVA | |
| rs479730574 | 303 | I>T | No | EVA | |
| rs448332449 | 304 | L>P | No | EVA | |
| rs467774131 | 309 | K>N | No | EVA | |
| rs481440388 | 311 | T>P | No | EVA | |
| rs470121871 | 315 | N>K | No | EVA | |
| rs432406519 | 316 | S>A | No | EVA | |
| rs452614246 | 324 | N>T | No | EVA | |
| rs466170582 | 326 | V>F | No | EVA | |
| rs455203163 | 328 | R>S | No | EVA | |
| rs435112902 | 328 | R>W | No | EVA | |
| rs482454343 | 333 | Y>C | No | EVA | |
| rs444654036 | 338 | S>T | No | EVA | |
| rs458303718 | 349 | Y>D | No | EVA | |
| rs478522554 | 350 | I>S | No | EVA | |
| rs480270492 | 358 | E>G | No | EVA | |
| rs466616400 | 358 | E>Q | No | EVA | |
| rs449012784 | 359 | T>P | No | EVA | |
| rs468916951 | 366 | V>G | No | EVA | |
| rs437611212 | 368 | P>Q | No | EVA | |
| rs451417806 | 371 | E>G | No | EVA | |
| rs464961913 | 373 | L>P | No | EVA | |
| rs433886087 | 377 | D>V | No | EVA | |
| rs453919609 | 378 | Q>P | No | EVA | |
| rs436243917 | 381 | V>G | No | EVA | |
| rs475783983 | 384 | S>R | No | EVA | |
| rs438136608 | 389 | P>A | No | EVA | |
| rs472029371 | 391 | D>E | No | EVA | |
| rs451823127 | 391 | D>G | No | EVA | |
| rs460709256 | 392 | D>E | No | EVA | |
| rs440603345 | 392 | D>G | No | EVA | |
| rs440603345 | 392 | D>V | No | EVA | |
| rs474535282 | 393 | G>V | No | EVA | |
| rs462416243 | 395 | E>* | No | EVA | |
| rs482402371 | 395 | E>D | No | EVA | |
| rs444946422 | 396 | S>I | No | EVA | |
| rs458463535 | 396 | S>R | No | EVA | |
| rs444946422 | 396 | S>T | No | EVA | |
| rs478711648 | 397 | Q>E | No | EVA | |
| rs447392774 | 397 | Q>P | No | EVA | |
| rs443451288 | 399 | F>V | No | EVA | |
| rs463523611 | 400 | C>R | No | EVA | |
| rs477317650 | 404 | Y>D | No | EVA | |
| rs445948038 | 425 | A>P | No | EVA | |
| rs479051013 | 427 | S>Y | No | EVA | |
| rs447726470 | 431 | F>C | No | EVA | |
| rs467898100 | 432 | E>G | No | EVA | |
| rs436406541 | 436 | R>G | No | EVA | |
| rs456593379 | 443 | G>R | No | EVA | |
| rs470174898 | 445 | A>P | No | EVA | |
| rs432675444 | 446 | D>A | No | EVA | |
| rs432675444 | 446 | D>G | No | EVA | |
| rs452774267 | 448 | Q>R | No | EVA |
No associated diseases with P21856
No regional properties for P21856
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P21856 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| midbody | A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| Rab GDP-dissociation inhibitor activity | Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of axonogenesis | Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis. |
| negative regulation of protein targeting to membrane | Any process that decreases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| Rab protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P39958 | GDI1 | Rab GDP-dissociation inhibitor | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P50397 | GDI2 | Rab GDP dissociation inhibitor beta | Bos taurus (Bovine) | PR |
| P60028 | GDI1 | Rab GDP dissociation inhibitor alpha | Pan troglodytes (Chimpanzee) | PR |
| O97555 | GDI1 | Rab GDP dissociation inhibitor alpha | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| P50395 | GDI2 | Rab GDP dissociation inhibitor beta | Homo sapiens (Human) | PR |
| P31150 | GDI1 | Rab GDP dissociation inhibitor alpha | Homo sapiens (Human) | PR |
| Q61598 | Gdi2 | Rab GDP dissociation inhibitor beta | Mus musculus (Mouse) | PR |
| P50396 | Gdi1 | Rab GDP dissociation inhibitor alpha | Mus musculus (Mouse) | PR |
| P50398 | Gdi1 | Rab GDP dissociation inhibitor alpha | Rattus norvegicus (Rat) | PR |
| P50399 | Gdi2 | Rab GDP dissociation inhibitor beta | Rattus norvegicus (Rat) | PR |
| O24653 | GDI2 | Guanosine nucleotide diphosphate dissociation inhibitor 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LXC0 | At5g09550 | Guanosine nucleotide diphosphate dissociation inhibitor At5g09550 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q96254 | GDI1 | Guanosine nucleotide diphosphate dissociation inhibitor 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDEEYDVIVL | GTGLTECILS | GIMSVNGKKV | LHMDRNPYYG | GESSSITPLE | ELYKRFQLLE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GPPETMGRGR | DWNVDLIPKF | LMANGQLVKM | LLYTEVTRYL | DFKVVEGSFV | YKGGKIYKVP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| STETEALASN | LMGMFEKRRF | RKFLVFVANF | DENDPKTFEG | VDPQNTSMRD | VYRKFDLGQD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VIDFTGHALA | LYRTDDYLDQ | PCLETINRIK | LYSESLARYG | KSPYLYPLYG | LGELPQGFAR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LSAIYGGTYM | LNKPVDDIIM | ENGKVVGVKS | EGEVARCKQL | ICDPSYVPDR | VRKAGQVIRI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ICILSHPIKN | TNDANSCQII | IPQNQVNRKS | DIYVCMISYA | HNVAAQGKYI | AIASTTVETT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DPEKEVEPAL | ELLEPIDQKF | VAISDLYEPI | DDGSESQVFC | SCSYDATTHF | ETTCNDIKDI |
| 430 | 440 | ||||
| YKRMAGSAFD | FENMKRKQND | VFGEADQ |