P31150
PR
Gene name |
GDI1 (GDIL, OPHN2, RABGDIA, XAP4) |
Protein name |
Rab GDP dissociation inhibitor alpha |
Names |
Rab GDI alpha, Guanosine diphosphate dissociation inhibitor 1, GDI-1, Oligophrenin-2, Protein XAP-4 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:2664 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P31150
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P31150-F1 | Predicted | AlphaFoldDB |
153 variants for P31150
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs121434608 CA121621 RCV000012393 |
70 | R>* | Intellectual disability, X-linked 41 [ClinVar] | Yes |
ClinGen ClinVar Ensembl dbSNP |
|
RCV001797587 rs121434607 CA121620 VAR_008130 RCV000012392 |
92 | L>P | Intellectual disability, X-linked 41 XLID41; causes reduced binding and recycling of RAB3A [ClinVar, UniProt] | Yes |
ClinGen ClinVar UniProt Ensembl dbSNP |
|
rs369835365 RCV002315277 CA10562961 |
128 | A>G | Inborn genetic diseases [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs1375956716 CA415203243 RCV000624361 |
138 | R>W | Inborn genetic diseases [ClinVar] | Yes |
ClinGen ClinVar TOPMed dbSNP |
|
rs782755945 RCV001260618 CA415203994 |
193 | R>L | Intellectual disability [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
rs2068750338 RCV001253206 |
263 | G>missing | Intellectual disability, X-linked 41 [ClinVar] | Yes |
ClinVar dbSNP |
|
RCV002316815 CA415206952 rs1569553456 |
289 | D>H | Inborn genetic diseases [ClinVar] | Yes |
ClinGen ClinVar Ensembl dbSNP |
|
RCV001252003 rs2068755805 |
354 | S>missing | Intellectual disability, X-linked 41 [ClinVar] | Yes |
ClinVar dbSNP |
|
RCV001253739 RCV001255375 rs2068757385 |
392 | D>T* | Intellectual disability Intellectual disability, X-linked 41 [ClinVar] | Yes |
ClinVar dbSNP |
|
rs398122814 RCV000022824 |
396 | S>missing | Intellectual disability, X-linked 41 [ClinVar] | Yes |
ClinVar dbSNP |
|
RCV000012394 CA121623 rs121434609 VAR_008131 |
423 | R>P | Intellectual disability, X-linked 41 XLID41 [ClinVar, UniProt] | Yes |
ClinGen ClinVar UniProt Ensembl dbSNP |
|
CA16621261 rs1064796588 RCV001197554 RCV000478709 |
428 | A>V | Intellectual disability, X-linked 41 [ClinVar] | Yes |
ClinGen ClinVar Ensembl dbSNP |
|
rs782709055 CA10562843 |
2 | D>N | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 5 | Y>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs781939489 CA10562844 |
8 | I>V | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 9 | V>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 12 | T>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1557197975 CA415198739 |
13 | G>S | No |
ClinGen gnomAD |
|
| TCGA novel | 17 | C>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 24 | S>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA415201323 rs1426513830 |
37 | P>H | No |
ClinGen TOPMed |
|
|
CA10562894 rs782638600 |
41 | G>A | No |
ClinGen ExAC gnomAD |
|
|
CA10562896 rs372327910 |
46 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA415201540 rs782473016 |
49 | L>V | No |
ClinGen ExAC |
|
|
rs782571802 CA10562924 |
54 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
rs782192899 CA10562925 |
55 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs1557198301 CA415201939 |
61 | G>E | No |
ClinGen gnomAD |
|
|
CA10562926 rs199816411 |
63 | P>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1483016125 CA415202015 |
64 | E>G | No |
ClinGen TOPMed |
|
|
CA16621260 RCV000482246 rs1064796769 |
65 | S>L | No |
ClinGen ClinVar dbSNP gnomAD |
|
| TCGA novel | 65 | S>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA415202035 RCV000503006 rs1557198307 |
65 | S>T | No |
ClinGen ClinVar Ensembl dbSNP |
|
|
rs1064796769 CA415202042 |
65 | S>W | No |
ClinGen gnomAD |
|
|
rs1236930706 CA415202105 |
68 | R>G | No |
ClinGen TOPMed |
|
|
CA10562929 rs782398267 |
69 | G>S | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 71 | D>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs373515131 CA10562931 RCV000514221 |
76 | L>V | No |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1232151642 CA415202311 |
78 | P>S | No |
ClinGen TOPMed |
|
|
rs1330317228 CA415202416 |
84 | N>D | No |
ClinGen TOPMed |
|
| rs1557198351 | 85 | G>= | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 86 | Q>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs781969088 CA10562953 |
92 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA415202751 rs1206505446 |
111 | Y>C | No |
ClinGen TOPMed |
|
|
CA10562957 rs782779627 |
112 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs1557198365 RCV000499956 CA415202768 |
113 | G>E | No |
ClinGen ClinVar dbSNP gnomAD |
|
|
TCGA novel rs782485883 CA10562959 |
114 | G>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA |
|
CA10562958 rs781873561 |
114 | G>C | No |
ClinGen ExAC gnomAD |
|
|
CA337298506 rs887682009 |
115 | K>R | No |
ClinGen TOPMed |
|
|
rs1557198533 CA415203206 |
133 | G>A | No |
ClinGen gnomAD |
|
|
CA415203225 rs1557198535 |
135 | F>L | No |
ClinGen gnomAD |
|
|
rs1557198536 CA415203227 |
136 | E>Q | No |
ClinGen gnomAD |
|
|
CA415203248 rs1557198539 |
139 | R>C | No |
ClinGen gnomAD |
|
|
rs782153547 CA415203264 |
141 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs782153547 CA10562994 |
141 | R>L | No |
ClinGen ExAC gnomAD |
|
|
CA415203314 rs1419794378 |
149 | N>D | No |
ClinGen TOPMed gnomAD |
|
|
rs1419794378 CA415203313 |
149 | N>H | No |
ClinGen TOPMed gnomAD |
|
|
CA415203319 rs1557198545 |
149 | N>K | No |
ClinGen gnomAD |
|
|
CA415203322 rs1557198548 |
150 | F>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA415203345 rs1557198552 |
152 | E>G | No |
ClinGen gnomAD |
|
|
CA415203359 rs1180730896 |
153 | N>S | No |
ClinGen TOPMed |
|
| TCGA novel | 157 | T>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA415203415 rs1557198562 |
157 | T>S | No |
ClinGen gnomAD |
|
|
CA415203436 RCV000498377 rs1557198566 |
158 | F>S | No |
ClinGen ClinVar Ensembl dbSNP |
|
|
CA415203472 rs782515310 |
161 | V>F | No |
ClinGen ExAC gnomAD |
|
|
CA10563003 rs782515310 |
161 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA415203470 rs782515310 |
161 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA337299078 rs959323773 |
164 | Q>H | No |
ClinGen Ensembl |
|
|
rs1032352955 CA337299076 |
164 | Q>P | No |
ClinGen TOPMed |
|
|
CA10563005 rs782218380 |
165 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA415203537 rs1346713482 |
165 | T>S | No |
ClinGen TOPMed |
|
|
rs1557198579 CA415203580 |
168 | M>T | No |
ClinGen gnomAD |
|
|
rs782493570 CA10563006 |
171 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA415203626 rs1253930257 |
173 | R>Q | No |
ClinGen TOPMed |
|
|
rs782575041 COSM457113 CA10563007 |
173 | R>W | Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
| TCGA novel | 178 | G>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1557198588 CA415203727 |
179 | Q>H | No |
ClinGen Ensembl |
|
|
rs1557198592 CA415203754 |
181 | V>I | No |
ClinGen gnomAD |
|
|
CA10563012 rs782341404 |
182 | I>T | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 188 | A>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs782348055 CA10563017 |
192 | Y>C | No |
ClinGen 1000Genomes ExAC |
|
|
rs1334602482 CA415203978 |
193 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
CA10563018 rs782755945 |
193 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA415204006 rs1557198602 |
194 | T>N | No |
ClinGen gnomAD |
|
|
rs782322629 CA10563037 |
205 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1326048690 CA415204523 |
206 | V>I | No |
ClinGen TOPMed gnomAD |
|
|
rs868992491 COSM457114 CA415204601 |
208 | R>H | Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated Ensembl NCI-TCGA |
|
rs782096197 CA10563039 |
212 | Y>C | No |
ClinGen ExAC |
|
|
CA10563040 rs782724839 |
218 | R>Q | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 219 | Y>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs781868282 CA10563041 |
224 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA337299437 rs112686555 |
225 | L>V | No |
ClinGen Ensembl |
|
| TCGA novel | 240 | R>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 248 | T>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs11549300 CA10563062 |
256 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA337300044 rs11549300 |
256 | D>Y | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 259 | I>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10563064 rs782553556 |
260 | M>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782353238 CA337300052 |
263 | G>S | No |
ClinGen Ensembl |
|
|
rs1324100712 CA415206389 |
264 | K>R | No |
ClinGen TOPMed |
|
|
rs781807551 CA10563066 |
266 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA10563087 rs782477424 |
276 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10563088 rs367767418 |
278 | K>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10563089 rs781848542 |
287 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs782594873 CA10563091 |
288 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs1214056877 CA415206942 |
288 | P>S | No |
ClinGen TOPMed |
|
|
CA415206962 rs1557198938 |
289 | D>G | No |
ClinGen gnomAD |
|
|
CA415206976 rs1345871844 |
290 | R>H | No |
ClinGen TOPMed |
|
|
rs782607768 CA10563094 |
292 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782493730 CA10563093 |
292 | R>W | No |
ClinGen ExAC gnomAD |
|
|
rs1557198952 CA415207116 |
299 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs782030587 CA10563097 |
299 | R>S | No |
ClinGen ExAC |
|
|
CA415207257 rs1557198956 |
308 | I>V | No |
ClinGen gnomAD |
|
|
CA10563100 rs781917575 |
313 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs868908537 CA415207377 |
314 | A>D | No |
ClinGen Ensembl |
|
|
rs782128887 CA10563102 |
314 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
| TCGA novel | 327 | N>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs782169795 CA415207758 |
336 | M>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782169795 CA10563127 |
336 | M>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1557199031 CA415207793 |
337 | I>M | No |
ClinGen gnomAD |
|
|
CA337300778 rs983015889 |
339 | Y>C | No |
ClinGen Ensembl |
|
|
rs1458210975 CA415207916 |
345 | A>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs1557199037 CA415207923 |
345 | A>V | No |
ClinGen gnomAD |
|
|
CA10563131 rs782606377 |
350 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs781819035 CA10563132 |
355 | T>S | No |
ClinGen ExAC gnomAD |
|
|
CA10563133 rs150955632 |
360 | T>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10563134 rs782629762 |
360 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782289676 CA10563135 |
361 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA415209793 rs1557199054 |
369 | A>V | No |
ClinGen gnomAD |
|
| TCGA novel | 370 | L>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10563138 rs782346555 |
377 | D>V | No |
ClinGen ExAC gnomAD |
|
|
rs782600356 CA10563154 |
381 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA10563155 rs782263053 |
383 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA337300988 rs782655354 |
387 | Y>F | No |
ClinGen 1000Genomes gnomAD |
|
|
CA415210146 rs1557199100 |
387 | Y>H | No |
ClinGen gnomAD |
|
|
CA415210198 rs1557199102 |
390 | I>V | No |
ClinGen gnomAD |
|
|
CA337301126 rs375181856 |
409 | H>Q | No |
ClinGen ESP TOPMed |
|
|
rs1569553475 RCV000782056 CA415210632 |
413 | T>A | No |
ClinGen ClinVar Ensembl dbSNP |
|
|
CA415210661 rs1395798124 |
415 | N>D | No |
ClinGen TOPMed |
|
|
rs1557199126 CA415210683 |
416 | D>N | No |
ClinGen gnomAD |
|
|
rs1471022308 CA415210816 |
424 | M>V | No |
ClinGen TOPMed |
|
|
CA415210825 rs1557199133 |
425 | A>T | No |
ClinGen gnomAD |
|
|
CA415210836 rs1557199134 |
425 | A>V | No |
ClinGen gnomAD |
|
|
rs138939602 CA10563180 RCV001818897 RCV000930319 |
427 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ClinVar ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
CA10563182 rs781915148 |
428 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1365920642 CA415210931 |
430 | D>Y | No |
ClinGen TOPMed |
|
|
CA10563183 rs782090801 |
434 | M>V | No |
ClinGen ExAC gnomAD |
|
|
CA415211056 rs1603385587 |
435 | K>N | No |
ClinGen Ensembl |
|
|
CA337301188 rs1016702150 |
440 | D>N | No |
ClinGen Ensembl |
|
|
CA10563185 rs368376382 |
440 | D>V | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1557199147 CA415211157 |
441 | V>I | No |
ClinGen gnomAD |
|
|
CA10563187 rs782788866 |
442 | F>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10563188 rs781807167 |
446 | E>V | No |
ClinGen ExAC gnomAD |
|
|
rs1462312464 CA415211263 |
447 | Q>* | No |
ClinGen TOPMed |
1 associated diseases with P31150
[MIM: 300849]: Intellectual developmental disorder, X-linked 41 (XLID41)
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked forms, while syndromic forms present with associated physical, neurological and/or psychiatric manifestations. {ECO:0000269|PubMed:9620768, ECO:0000269|PubMed:9668174}. Note=The disease is caused by variants affecting the gene represented in this entry.
Without disease ID
- A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked forms, while syndromic forms present with associated physical, neurological and/or psychiatric manifestations. {ECO:0000269|PubMed:9620768, ECO:0000269|PubMed:9668174}. Note=The disease is caused by variants affecting the gene represented in this entry.
No regional properties for P31150
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P31150 | |||
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| midbody | A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. |
| myelin sheath | An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| GDP-dissociation inhibitor activity | Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding. |
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| Rab GDP-dissociation inhibitor activity | Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding. |
| small GTPase binding | Binding to a small monomeric GTPase. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of axonogenesis | Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis. |
| negative regulation of protein targeting to membrane | Any process that decreases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. |
| positive regulation of axon extension | Any process that activates or increases the frequency, rate or extent of axon extension. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| Rab protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state. |
| response to calcium ion | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P39958 | GDI1 | Rab GDP-dissociation inhibitor | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P50397 | GDI2 | Rab GDP dissociation inhibitor beta | Bos taurus (Bovine) | PR |
| P21856 | GDI1 | Rab GDP dissociation inhibitor alpha | Bos taurus (Bovine) | PR |
| P60028 | GDI1 | Rab GDP dissociation inhibitor alpha | Pan troglodytes (Chimpanzee) | PR |
| O97555 | GDI1 | Rab GDP dissociation inhibitor alpha | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| P50395 | GDI2 | Rab GDP dissociation inhibitor beta | Homo sapiens (Human) | PR |
| Q61598 | Gdi2 | Rab GDP dissociation inhibitor beta | Mus musculus (Mouse) | PR |
| P50396 | Gdi1 | Rab GDP dissociation inhibitor alpha | Mus musculus (Mouse) | PR |
| P50398 | Gdi1 | Rab GDP dissociation inhibitor alpha | Rattus norvegicus (Rat) | PR |
| P50399 | Gdi2 | Rab GDP dissociation inhibitor beta | Rattus norvegicus (Rat) | PR |
| O24653 | GDI2 | Guanosine nucleotide diphosphate dissociation inhibitor 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LXC0 | At5g09550 | Guanosine nucleotide diphosphate dissociation inhibitor At5g09550 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q96254 | GDI1 | Guanosine nucleotide diphosphate dissociation inhibitor 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDEEYDVIVL | GTGLTECILS | GIMSVNGKKV | LHMDRNPYYG | GESSSITPLE | ELYKRFQLLE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GPPESMGRGR | DWNVDLIPKF | LMANGQLVKM | LLYTEVTRYL | DFKVVEGSFV | YKGGKIYKVP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| STETEALASN | LMGMFEKRRF | RKFLVFVANF | DENDPKTFEG | VDPQTTSMRD | VYRKFDLGQD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VIDFTGHALA | LYRTDDYLDQ | PCLETVNRIK | LYSESLARYG | KSPYLYPLYG | LGELPQGFAR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LSAIYGGTYM | LNKPVDDIIM | ENGKVVGVKS | EGEVARCKQL | ICDPSYIPDR | VRKAGQVIRI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ICILSHPIKN | TNDANSCQII | IPQNQVNRKS | DIYVCMISYA | HNVAAQGKYI | AIASTTVETT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DPEKEVEPAL | ELLEPIDQKF | VAISDLYEPI | DDGCESQVFC | SCSYDATTHF | ETTCNDIKDI |
| 430 | 440 | ||||
| YKRMAGTAFD | FENMKRKQND | VFGEAEQ |