P39958

PR
Gene name
GDI1 (SEC19, YER136W)
Protein name
Rab GDP-dissociation inhibitor
Names
Rab GDI, Secretory pathway GDP dissociation inhibitor
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YER136W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

30-104 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for P39958

Entry ID Method Resolution Chain Position Source
1UKV X-ray 150 A G 1-451 PDB
2BCG X-ray 148 A G 1-451 PDB
3CPH X-ray 290 A G/H 1-451 PDB
3CPI X-ray 230 A G/H 1-451 PDB
3CPJ X-ray 235 A G 1-451 PDB
AF-P39958-F1 Predicted AlphaFoldDB

2 variants for P39958

Variant ID(s) Position Change Description Diseaes Association Provenance
s05-439933 108 V>I No SGRP
s05-440424 271 D>E No SGRP

No associated diseases with P39958

No regional properties for P39958

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P39958

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
Rab GDP-dissociation inhibitor activity Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding.

3 GO annotations of biological process

Name Definition
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
small GTPase mediated signal transduction The series of molecular signals in which a small monomeric GTPase relays a signal.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P50397 GDI2 Rab GDP dissociation inhibitor beta Bos taurus (Bovine) PR
P21856 GDI1 Rab GDP dissociation inhibitor alpha Bos taurus (Bovine) PR
P60028 GDI1 Rab GDP dissociation inhibitor alpha Pan troglodytes (Chimpanzee) PR
O97556 GDI2 Rab GDP dissociation inhibitor beta Canis lupus familiaris (Dog) (Canis familiaris) PR
O97555 GDI1 Rab GDP dissociation inhibitor alpha Canis lupus familiaris (Dog) (Canis familiaris) PR
P50395 GDI2 Rab GDP dissociation inhibitor beta Homo sapiens (Human) PR
P31150 GDI1 Rab GDP dissociation inhibitor alpha Homo sapiens (Human) PR
Q61598 Gdi2 Rab GDP dissociation inhibitor beta Mus musculus (Mouse) PR
P50396 Gdi1 Rab GDP dissociation inhibitor alpha Mus musculus (Mouse) PR
P50399 Gdi2 Rab GDP dissociation inhibitor beta Rattus norvegicus (Rat) PR
P50398 Gdi1 Rab GDP dissociation inhibitor alpha Rattus norvegicus (Rat) PR
Q9LXC0 At5g09550 Guanosine nucleotide diphosphate dissociation inhibitor At5g09550 Arabidopsis thaliana (Mouse-ear cress) PR
O24653 GDI2 Guanosine nucleotide diphosphate dissociation inhibitor 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q96254 GDI1 Guanosine nucleotide diphosphate dissociation inhibitor 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MDQETIDTDY DVIVLGTGIT ECILSGLLSV DGKKVLHIDK QDHYGGEAAS VTLSQLYEKF
70 80 90 100 110 120
KQNPISKEER ESKFGKDRDW NVDLIPKFLM ANGELTNILI HTDVTRYVDF KQVSGSYVFK
130 140 150 160 170 180
QGKIYKVPAN EIEAISSPLM GIFEKRRMKK FLEWISSYKE DDLSTHQGLD LDKNTMDEVY
190 200 210 220 230 240
YKFGLGNSTK EFIGHAMALW TNDDYLQQPA RPSFERILLY CQSVARYGKS PYLYPMYGLG
250 260 270 280 290 300
ELPQGFARLS AIYGGTYMLD TPIDEVLYKK DTGKFEGVKT KLGTFKAPLV IADPTYFPEK
310 320 330 340 350 360
CKSTGQRVIR AICILNHPVP NTSNADSLQI IIPQSQLGRK SDIYVAIVSD AHNVCSKGHY
370 380 390 400 410 420
LAIISTIIET DKPHIELEPA FKLLGPIEEK FMGIAELFEP REDGSKDNIY LSRSYDASSH
430 440 450
FESMTDDVKD IYFRVTGHPL VLKQRQEQEK Q