O24653
Gene name |
GDI2 (At3g59920, F24G16.190) |
Protein name |
Guanosine nucleotide diphosphate dissociation inhibitor 2 |
Names |
Allergen Phl p 11, Pollen allergen Phl p 12, Profilin 4, AtGDI2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G59920 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O24653
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O24653-F1 | Predicted | AlphaFoldDB |
10 variants for O24653
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_22135181_G_A | 9 | V>I | No | 1000Genomes | |
| ENSVATH12841698 | 67 | A>S | No | 1000Genomes | |
| ENSVATH14457768 | 93 | T>S | No | 1000Genomes | |
| tmp_3_22136121_A_C | 156 | T>P | No | 1000Genomes | |
| tmp_3_22136155_C_T | 167 | T>I | No | 1000Genomes | |
| tmp_3_22137284_C_T | 308 | P>L | No | 1000Genomes | |
| ENSVATH02527923 | 372 | D>G | No | 1000Genomes | |
| tmp_3_22137823_G_A | 377 | V>I | No | 1000Genomes | |
| tmp_3_22138181_T_C | 432 | L>P | No | 1000Genomes | |
| tmp_3_22138207_G_T | 441 | A>S | No | 1000Genomes |
No associated diseases with O24653
No regional properties for O24653
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O24653 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| apoplast | The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| plasmodesma | A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| Rab GDP-dissociation inhibitor activity | Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| small GTPase mediated signal transduction | The series of molecular signals in which a small monomeric GTPase relays a signal. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P39958 | GDI1 | Rab GDP-dissociation inhibitor | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P21856 | GDI1 | Rab GDP dissociation inhibitor alpha | Bos taurus (Bovine) | PR |
| P50397 | GDI2 | Rab GDP dissociation inhibitor beta | Bos taurus (Bovine) | PR |
| P60028 | GDI1 | Rab GDP dissociation inhibitor alpha | Pan troglodytes (Chimpanzee) | PR |
| O97556 | GDI2 | Rab GDP dissociation inhibitor beta | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| O97555 | GDI1 | Rab GDP dissociation inhibitor alpha | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| P31150 | GDI1 | Rab GDP dissociation inhibitor alpha | Homo sapiens (Human) | PR |
| P50395 | GDI2 | Rab GDP dissociation inhibitor beta | Homo sapiens (Human) | PR |
| P50396 | Gdi1 | Rab GDP dissociation inhibitor alpha | Mus musculus (Mouse) | PR |
| Q61598 | Gdi2 | Rab GDP dissociation inhibitor beta | Mus musculus (Mouse) | PR |
| P50398 | Gdi1 | Rab GDP dissociation inhibitor alpha | Rattus norvegicus (Rat) | PR |
| P50399 | Gdi2 | Rab GDP dissociation inhibitor beta | Rattus norvegicus (Rat) | PR |
| Q9LXC0 | At5g09550 | Guanosine nucleotide diphosphate dissociation inhibitor At5g09550 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q96254 | GDI1 | Guanosine nucleotide diphosphate dissociation inhibitor 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDEEYEVIVL | GTGLKECILS | GLLSVDGVKV | LHMDRNDYYG | GESTSLNLNQ | LWKKFRGEEK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| APEHLGASRD | YNVDMMPKFM | MGNGKLVRTL | IHTDVTKYLS | FKAVDGSYVF | VKGKVQKVPA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TPMEALKSSL | MGIFEKRRAG | KFFSFVQEYD | EKDPKTHDGM | DLTRVTTKEL | IAKYGLDGNT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IDFIGHAVAL | HTNDQHLDQP | AFDTVMRMKL | YAESLARFQG | TSPYIYPLYG | LGELPQAFAR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LSAVYGGTYM | LNKPECKVEF | DEGGKVIGVT | SEGETAKCKK | IVCDPSYLPN | KVRKIGRVAR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AIAIMSHPIP | NTNDSHSVQV | IIPQKQLARK | SDMYVFCCSY | SHNVAPKGKF | IAFVSTDAET |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DNPQTELKPG | TDLLGPVDEI | FFDMYDRYEP | VNEPELDNCF | ISTSYDATTH | FETTVADVLN |
| 430 | 440 | ||||
| MYTLITGKQL | DLSVDLSAAS | AAEE |