P60028
Gene name |
GDI1 (RABGDIA) |
Protein name |
Rab GDP dissociation inhibitor alpha |
Names |
Rab GDI alpha, Guanosine diphosphate dissociation inhibitor 1, GDI-1 |
Species |
Pan troglodytes (Chimpanzee) |
KEGG Pathway |
ptr:450155 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P60028
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P60028-F1 | Predicted | AlphaFoldDB |
No variants for P60028
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P60028 | |||||
No associated diseases with P60028
No regional properties for P60028
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P60028 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| Rab GDP-dissociation inhibitor activity | Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of axonogenesis | Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis. |
| negative regulation of protein targeting to membrane | Any process that decreases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| Rab protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P39958 | GDI1 | Rab GDP-dissociation inhibitor | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P50397 | GDI2 | Rab GDP dissociation inhibitor beta | Bos taurus (Bovine) | PR |
| P21856 | GDI1 | Rab GDP dissociation inhibitor alpha | Bos taurus (Bovine) | PR |
| O97555 | GDI1 | Rab GDP dissociation inhibitor alpha | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| P50395 | GDI2 | Rab GDP dissociation inhibitor beta | Homo sapiens (Human) | PR |
| P31150 | GDI1 | Rab GDP dissociation inhibitor alpha | Homo sapiens (Human) | PR |
| Q61598 | Gdi2 | Rab GDP dissociation inhibitor beta | Mus musculus (Mouse) | PR |
| P50396 | Gdi1 | Rab GDP dissociation inhibitor alpha | Mus musculus (Mouse) | PR |
| P50399 | Gdi2 | Rab GDP dissociation inhibitor beta | Rattus norvegicus (Rat) | PR |
| P50398 | Gdi1 | Rab GDP dissociation inhibitor alpha | Rattus norvegicus (Rat) | PR |
| Q9LXC0 | At5g09550 | Guanosine nucleotide diphosphate dissociation inhibitor At5g09550 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O24653 | GDI2 | Guanosine nucleotide diphosphate dissociation inhibitor 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q96254 | GDI1 | Guanosine nucleotide diphosphate dissociation inhibitor 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDEEYDVIVL | GTGLTECILS | GIMSVNGKKV | LHMDRNPYYG | GESSSITPLE | ELYKRFQLLE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GPPESMGRGR | DWNVDLIPKF | LMANGQLVKM | LLYTEVTRYL | DFKVVEGSFV | YKGGKIYKVP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| STETEALASN | LMGMFEKRRF | RKFLVFVANF | DENDPKTFEG | VDPQTTSMRD | VYRKFDLGQD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VIDFTGHALA | LYRTDDYLDQ | PCLETVNRIK | LYSESLARYG | KSPYLYPLYG | LGELPQGFAR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LSAIYGGTYM | LNKPVDDIIM | ENGKVVGVKS | EGEVARCKQL | ICDPSYIPDR | VRKAGQVIRI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ICILSHPIKN | TNDANSCQII | IPQNQVNRKS | DIYVCMISYA | HNVAAQGKYI | AIASTTVETT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DPEKEVEPAL | ELLEPIDQKF | VAISDLYEPI | DDGCESQVFC | SCSYDATTHF | ETTCNDIKDI |
| 430 | 440 | ||||
| YKRMAGTAFD | FENMKRKQND | VFGEAEQ |