P50396
PR
Gene name |
Gdi1 (Rabgdia) |
Protein name |
Rab GDP dissociation inhibitor alpha |
Names |
Rab GDI alpha, Guanosine diphosphate dissociation inhibitor 1, GDI-1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:14567 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P50396
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P50396-F1 | Predicted | AlphaFoldDB |
26 variants for P50396
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389532829 | 12 | T>A | No | EVA | |
| rs3389544312 | 35 | R>* | No | EVA | |
| rs29035837 | 58 | I>M | No | EVA | |
| rs3410732875 | 89 | K>N | No | EVA | |
| rs3410689415 | 91 | L>V | No | EVA | |
| rs3389521889 | 121 | S>P | No | EVA | |
| rs3410682492 | 131 | L>Q | No | EVA | |
| rs3389580922 | 132 | M>R | No | EVA | |
| rs3389513540 | 155 | P>T | No | EVA | |
| rs3389567203 | 162 | D>V | No | EVA | |
| rs3389521862 | 193 | R>H | No | EVA | |
| rs3389569037 | 211 | L>F | No | EVA | |
| rs3410732859 | 235 | P>L | No | EVA | |
| rs3411055143 | 243 | A>V | No | EVA | |
| rs3410943339 | 245 | Y>H | No | EVA | |
| rs3410683437 | 249 | Y>C | No | EVA | |
| rs3409332074 | 257 | D>G | No | EVA | |
| rs3410689390 | 263 | G>D | No | EVA | |
| rs3389575782 | 276 | R>H | No | EVA | |
| rs3389567226 | 286 | Y>H | No | EVA | |
| rs3410802019 | 305 | S>I | No | EVA | |
| rs3389558717 | 344 | A>D | No | EVA | |
| rs3411312691 | 365 | E>A | No | EVA | |
| rs3389564340 | 372 | L>P | No | EVA | |
| rs3410311537 | 390 | I>F | No | EVA | |
| rs3389575744 | 426 | G>S | No | EVA |
No associated diseases with P50396
No regional properties for P50396
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P50396 | |||
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| midbody | A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. |
| myelin sheath | An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| Rab GDP-dissociation inhibitor activity | Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding. |
| small GTPase binding | Binding to a small monomeric GTPase. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of axonogenesis | Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis. |
| negative regulation of protein targeting to membrane | Any process that decreases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. |
| positive regulation of axon extension | Any process that activates or increases the frequency, rate or extent of axon extension. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| Rab protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state. |
| response to calcium ion | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P39958 | GDI1 | Rab GDP-dissociation inhibitor | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P50397 | GDI2 | Rab GDP dissociation inhibitor beta | Bos taurus (Bovine) | PR |
| P21856 | GDI1 | Rab GDP dissociation inhibitor alpha | Bos taurus (Bovine) | PR |
| P60028 | GDI1 | Rab GDP dissociation inhibitor alpha | Pan troglodytes (Chimpanzee) | PR |
| O97555 | GDI1 | Rab GDP dissociation inhibitor alpha | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| P50395 | GDI2 | Rab GDP dissociation inhibitor beta | Homo sapiens (Human) | PR |
| P31150 | GDI1 | Rab GDP dissociation inhibitor alpha | Homo sapiens (Human) | PR |
| Q61598 | Gdi2 | Rab GDP dissociation inhibitor beta | Mus musculus (Mouse) | PR |
| Q9QZD5 | Chml | Rab proteins geranylgeranyltransferase component A 2 | Mus musculus (Mouse) | PR |
| P50398 | Gdi1 | Rab GDP dissociation inhibitor alpha | Rattus norvegicus (Rat) | PR |
| P50399 | Gdi2 | Rab GDP dissociation inhibitor beta | Rattus norvegicus (Rat) | PR |
| O24653 | GDI2 | Guanosine nucleotide diphosphate dissociation inhibitor 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LXC0 | At5g09550 | Guanosine nucleotide diphosphate dissociation inhibitor At5g09550 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q96254 | GDI1 | Guanosine nucleotide diphosphate dissociation inhibitor 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDEEYDVIVL | GTGLTECILS | GIMSVNGKKV | LHMDRNPYYG | GESSSITPLE | ELYKRFQILE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GPPESMGRGR | DWNVDLIPKF | LMANGQLVKM | LLYTEVTRYL | DFKVVEGSFV | YKGGKIYKVP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| STETEALASN | LMGMFEKRRF | RKFLVFVANF | DENDPKTFEG | VDPQNTSMRD | VYRKFDLGQD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VIDFTGHALA | LYRTDDYLDQ | PCLETINRIK | LYSESLARYG | KSPYLYPLYG | LGELPQGFAR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LSAIYGGTYM | LNKPVDDIIM | ENGKVVGVKS | EGEVARCKQL | ICDPSYIPDR | VQKAGQVIRI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ICILSHPIKN | TNDANSCQII | IPQNQVNRKS | DIYVCMISYA | HNVAAQGKYI | AIASTTVETA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EPEKEVEPAL | ELLEPIDQKF | VAISDLYEPI | DDGSESQVFC | SCSYDATTHF | ETTCNDIKDI |
| 430 | 440 | ||||
| YKRMAGSAFD | FENMKRKQND | VFGEADQ |