Q9QZD5
Gene name |
Chml (Rep2) |
Protein name |
Rab proteins geranylgeranyltransferase component A 2 |
Names |
Choroideremia-like protein, Rab escort protein 2, REP-2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:12663 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9QZD5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9QZD5-F1 | Predicted | AlphaFoldDB |
No variants for Q9QZD5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9QZD5 | |||||
1 associated diseases with Q9QZD5
Without disease ID
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| Rab-protein geranylgeranyltransferase complex | An protein-containing complex which catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein. In mammals it is composed of an alpha and a beta subunit, and associates with an accessory protein Rep (Rab escort protein). |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GDP-dissociation inhibitor activity | Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding. |
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| small GTPase binding | Binding to a small monomeric GTPase. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| protein geranylgeranylation | The covalent attachment of a geranylgeranyl group to a protein. |
| small GTPase mediated signal transduction | The series of molecular signals in which a small monomeric GTPase relays a signal. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEKLPTEFD | VVIIGTGLPE | SILAAACSRS | GQRVLHVDSR | SYYGGNWASF | SFTGLQSWLK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DYQQNHDSEE | GVTATWQDLI | HETEEAISLR | KKDETIQHTE | VFCYASQDVE | DSVQDTETLQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RSSPLEASAT | PADSLDSASL | PKERQSAYST | SYEVPSRHTE | ESDRELSLPS | ANVEDSLEKE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KYCGDKTDMH | TVSGEDKGEH | KLVVQDSIEQ | PKRNRITYSQ | MVKESRRFNI | DLVSKPLYSQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GSLIDLLIKS | NVSRYAEFKN | VTRILAFWEG | KVEQVPCSRA | DVFNSKELSM | VEKRMLMKFL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TFCLDYEQHS | DEYQDFKQCS | FSDYLKTKKL | TPNLQHFILH | SIAMTSESSC | TTLDGLQATK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NFLQCLGRFG | NTPFIFPLYG | HGEIPQCFCR | MCAVFGGVYC | LRHKVQCLVV | DKDSGRCKGI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IDAFGQRISA | NYFIVEDSYL | PKETCSNVQY | KQISRAVLIT | DQSILKTDSD | QQISILVVPP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LEPGTTSVRV | MELCSSTMTC | MKDSYLVHLT | CSSSKTARED | LEPVVKQLFI | PEAEAEAGKD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ELRKPRLLWA | LYFNMRDSSG | VSRSSYCGLP | SNVYICSGPD | WGLGSEHAVK | QAETLFQEIF |
| 610 | 620 | ||||
| PSEEFCPPPP | NPEDIIFEAE | G |