Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q9QZD5

Entry ID Method Resolution Chain Position Source
AF-Q9QZD5-F1 Predicted AlphaFoldDB

No variants for Q9QZD5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9QZD5

1 associated diseases with Q9QZD5

Without disease ID

2 regional properties for Q9QZD5

Type Name Position InterPro Accession
conserved_site Sugar transporter, conserved site 160 - 176 IPR005829
domain Major facilitator superfamily domain 88 - 514 IPR020846

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
Rab-protein geranylgeranyltransferase complex An protein-containing complex which catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein. In mammals it is composed of an alpha and a beta subunit, and associates with an accessory protein Rep (Rab escort protein).

3 GO annotations of molecular function

Name Definition
GDP-dissociation inhibitor activity Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding.
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
small GTPase binding Binding to a small monomeric GTPase.

4 GO annotations of biological process

Name Definition
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
protein geranylgeranylation The covalent attachment of a geranylgeranyl group to a protein.
small GTPase mediated signal transduction The series of molecular signals in which a small monomeric GTPase relays a signal.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P50396 Gdi1 Rab GDP dissociation inhibitor alpha Mus musculus (Mouse) PR
Q61598 Gdi2 Rab GDP dissociation inhibitor beta Mus musculus (Mouse) PR
10 20 30 40 50 60
MAEKLPTEFD VVIIGTGLPE SILAAACSRS GQRVLHVDSR SYYGGNWASF SFTGLQSWLK
70 80 90 100 110 120
DYQQNHDSEE GVTATWQDLI HETEEAISLR KKDETIQHTE VFCYASQDVE DSVQDTETLQ
130 140 150 160 170 180
RSSPLEASAT PADSLDSASL PKERQSAYST SYEVPSRHTE ESDRELSLPS ANVEDSLEKE
190 200 210 220 230 240
KYCGDKTDMH TVSGEDKGEH KLVVQDSIEQ PKRNRITYSQ MVKESRRFNI DLVSKPLYSQ
250 260 270 280 290 300
GSLIDLLIKS NVSRYAEFKN VTRILAFWEG KVEQVPCSRA DVFNSKELSM VEKRMLMKFL
310 320 330 340 350 360
TFCLDYEQHS DEYQDFKQCS FSDYLKTKKL TPNLQHFILH SIAMTSESSC TTLDGLQATK
370 380 390 400 410 420
NFLQCLGRFG NTPFIFPLYG HGEIPQCFCR MCAVFGGVYC LRHKVQCLVV DKDSGRCKGI
430 440 450 460 470 480
IDAFGQRISA NYFIVEDSYL PKETCSNVQY KQISRAVLIT DQSILKTDSD QQISILVVPP
490 500 510 520 530 540
LEPGTTSVRV MELCSSTMTC MKDSYLVHLT CSSSKTARED LEPVVKQLFI PEAEAEAGKD
550 560 570 580 590 600
ELRKPRLLWA LYFNMRDSSG VSRSSYCGLP SNVYICSGPD WGLGSEHAVK QAETLFQEIF
610 620
PSEEFCPPPP NPEDIIFEAE G