Q05CL8
PR
Gene name |
Larp7 |
Protein name |
La-related protein 7 |
Names |
La ribonucleoprotein domain family member 7 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:28036 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q05CL8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q05CL8-F1 | Predicted | AlphaFoldDB |
51 variants for Q05CL8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388657813 | 43 | A>V | No | EVA | |
| rs230606323 | 49 | K>R | No | EVA | |
| rs3388662048 | 57 | K>T | No | EVA | |
| rs3388659875 | 62 | Y>* | No | EVA | |
| rs3388662020 | 86 | R>I | No | EVA | |
| rs3388655703 | 90 | S>G | No | EVA | |
| rs3388644872 | 136 | E>V | No | EVA | |
| rs3388657753 | 137 | R>S | No | EVA | |
| rs3388657807 | 139 | F>C | No | EVA | |
| rs3388666173 | 159 | P>H | No | EVA | |
| rs3388659902 | 160 | K>* | No | EVA | |
| rs3388652167 | 160 | K>R | No | EVA | |
| rs3388657800 | 161 | G>R | No | EVA | |
| rs3413058504 | 188 | P>L | No | EVA | |
| rs259105611 | 207 | R>Q | No | EVA | |
| rs581241976 | 209 | A>T | No | EVA | |
| rs3388644891 | 219 | K>E | No | EVA | |
| rs3388651100 | 224 | K>N | No | EVA | |
| rs13462046 | 242 | V>L | No | EVA | |
| rs583847846 | 257 | E>G | No | EVA | |
| rs3388663044 | 271 | K>* | No | EVA | |
| rs3388660999 | 272 | K>R | No | EVA | |
| rs3388652059 | 273 | K>M | No | EVA | |
| rs50312911 | 287 | A>S | No | EVA | |
| rs3388651170 | 298 | E>V | No | EVA | |
| rs244766811 | 317 | G>S | No | EVA | |
| rs3388659791 | 339 | K>N | No | EVA | |
| rs3388658443 | 340 | E>G | No | EVA | |
| rs1134900248 | 347 | S>P | No | EVA | |
| rs3388658494 | 360 | K>Q | No | EVA | |
| rs3388662002 | 361 | E>V | No | EVA | |
| rs3388659883 | 362 | R>S | No | EVA | |
| rs3388666991 | 363 | H>D | No | EVA | |
| rs3388651133 | 363 | H>G* | No | EVA | |
| rs3388659886 | 363 | H>L | No | EVA | |
| rs252370177 | 372 | L>M | No | EVA | |
| rs3388652178 | 372 | L>S | No | EVA | |
| rs1133640676 | 382 | D>A | No | EVA | |
| rs1133308786 | 384 | K>R | No | EVA | |
| rs3388655706 | 426 | C>Y | No | EVA | |
| rs3388658488 | 441 | T>N | No | EVA | |
| rs212766778 | 498 | Q>H | No | EVA | |
| rs231156249 | 506 | S>C | No | EVA | |
| rs3388657779 | 540 | R>G | No | EVA | |
| rs3412945302 | 551 | K>Q | No | EVA | |
| rs3393655714 | 555 | A>C* | No | EVA | |
| rs3388652173 | 556 | K>* | No | EVA | |
| rs3393655714 | 556 | K>C | No | EVA | |
| rs3388652173 | 556 | K>E | No | EVA | |
| rs3388644863 | 556 | K>M | No | EVA | |
| rs3388664772 | 568 | E>Q | No | EVA |
No associated diseases with Q05CL8
6 regional properties for Q05CL8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | RNA recognition motif domain | 119 - 196 | IPR000504 |
| domain | La-type HTH domain | 22 - 116 | IPR006630 |
| domain | La protein, xRRM domain | 438 - 551 | IPR014886 |
| domain | LARP7, RNA recognition motif 1 | 120 - 199 | IPR034887 |
| domain | LARP7, RNA recognition motif 2 | 442 - 523 | IPR034910 |
| domain | La-related protein 7, La domain | 25 - 105 | IPR034946 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| 7SK snRNP | A ribonucleoprotein complex that contains the 7SK snRNA. The 7SK snRNP plays a central role in RNA polymerase II elongation control by regulating the availability of active P-TEFb. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| ribonucleoprotein complex | A macromolecular complex that contains both RNA and protein molecules. |
| small nuclear ribonucleoprotein complex | A ribonucleoprotein complex that contains at least one RNA of the small nuclear RNA (snRNA) class and as well as its associated proteins. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP, U4/U6 snRNP, or 7SK snRNP. Many, of these complexes become part of the spliceosome involved in splicing of nuclear mRNAs. Others are involved in regulation of transcription elongation or 3'-end processing of replication-dependent histone pre-mRNAs. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 7SK snRNA binding | Binding to a 7SK small nuclear RNA (7SK snRNA). |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| U6 snRNA binding | Binding to a U6 small nuclear RNA (U6 snRNA). |
14 GO annotations of biological process
| Name | Definition |
|---|---|
| box C/D RNA 3'-end processing | Any process involved in forming the mature 3' end of a box C/D RNA molecule. |
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| germ cell proliferation | The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population. |
| mRNA processing | Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. |
| negative regulation of chromatin binding | Any process that stops or reduces the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| negative regulation of viral transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription. |
| positive regulation of G1/S transition of mitotic cell cycle | Any signalling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. |
| positive regulation of protein localization to Cajal body | Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body. |
| positive regulation of snRNA transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of snRNA transcription mediated by RNA polymerase II. |
| regulation of mRNA splicing, via spliceosome | Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism. |
| RNA splicing | The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
| U6 2'-O-snRNA methylation | The posttranscriptional addition a methyl group to the 2'-oxygen atom of a nucleotide residue in an U6 snRNA molecule. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8N9W6 | BOLL | Protein boule-like | Homo sapiens (Human) | PR |
| P42696 | RBM34 | RNA-binding protein 34 | Homo sapiens (Human) | PR |
| Q4G0J3 | LARP7 | La-related protein 7 | Homo sapiens (Human) | PR |
| P05455 | SSB | Lupus La protein | Homo sapiens (Human) | PR |
| Q924M5 | Boll | Protein boule-like | Mus musculus (Mouse) | PR |
| Q8C854 | Myef2 | Myelin expression factor 2 | Mus musculus (Mouse) | PR |
| Q6ZQ58 | Larp1 | La-related protein 1 | Mus musculus (Mouse) | PR |
| Q5XI01 | Larp7 | La-related protein 7 | Rattus norvegicus (Rat) | PR |
| Q9S7N9 | CID12 | Polyadenylate-binding protein-interacting protein 12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93ZV7 | LA1 | La protein 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q4KM14 | trnau1apl | tRNA selenocysteine 1-associated protein 1-like | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| METENQKTME | ESTKRKEEKK | KRSRVKQVLA | DIAKQVDFWF | GDANLHKDKF | LREQIEKSRD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GYVDISLLVS | FNKMKKLTTD | GKLIARALKS | SSVVELDLEG | TRIRRKKPLG | ERPKDEEERT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VYVELLPKNV | THSWIERVFG | KCGNVVYISI | PHYKSTGDPK | GFAFVEFETK | EQAAKAIEFL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NNPPEEAPRK | PGIFPKTVKN | KPIPSLRVAE | EKKKKKKKKG | RIKKEESVQA | KESAVDSSSS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GVCKATKRPR | TASEGSEAET | PEAPKQPAKK | KKKRDKVEAS | SLPEARAGKR | ERCSAEDEDC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LPPRPKAKKR | AQKDGVGQAA | SEVSKESRDL | EFCSTEEEKE | TDRKGDSLSK | VKRKHKKKHK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ERHKMGEEVI | PLRVLSKTEW | MDLKKEYLAL | QKASMASLKK | TISQIKLESE | METDCKAPTA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GSGQECSTQE | KVSAQGPQFV | TGVIVKIVSG | EPLPGRKQVK | DILATISEVV | YIDLLEGDTE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| CHARFKTPED | AQAVMNAQTE | IRKKHSWNLE | VLSGDHEQRY | WQKILVDRQA | KLNQPREKKR |
| 550 | 560 | ||||
| GTEKLITKAE | KIRLAKTQQA | SQHIRFSEYD |