Q8C854
Gene name |
Myef2 (Kiaa1341, Mef2) |
Protein name |
Myelin expression factor 2 |
Names |
MEF-2, MyEF-2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:17876 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8C854
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8C854-F1 | Predicted | AlphaFoldDB |
17 variants for Q8C854
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388588111 | 243 | V>M | No | EVA | |
| rs3388588556 | 353 | S>N | No | EVA | |
| rs3388575749 | 370 | G>E | No | EVA | |
| rs3388575827 | 393 | G>R | No | EVA | |
| rs3388578938 | 394 | E>* | No | EVA | |
| rs3388588300 | 404 | M>L | No | EVA | |
| rs3388586669 | 406 | R>* | No | EVA | |
| rs3388586447 | 407 | D>V | No | EVA | |
| rs3388588099 | 411 | G>C | No | EVA | |
| rs3392213227 | 429 | A>V | No | EVA | |
| rs3392137195 | 431 | I>S | No | EVA | |
| rs3388583217 | 444 | G>A | No | EVA | |
| rs3388589813 | 533 | K>I | No | EVA | |
| rs3388586445 | 537 | C>* | No | EVA | |
| rs3388582325 | 538 | G>C | No | EVA | |
| rs3388585650 | 571 | R>S | No | EVA | |
| rs3388590865 | 588 | D>V | No | EVA |
No associated diseases with Q8C854
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| post-mRNA release spliceosomal complex | A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, including U5. |
| ribonucleoprotein complex | A macromolecular complex that contains both RNA and protein molecules. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription repressor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II. |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| single-stranded DNA binding | Binding to single-stranded DNA. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| regulation of mRNA stability involved in response to oxidative stress | A process of regulation of mRNA stability that is involved in a response to oxidative stress. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8N9W6 | BOLL | Protein boule-like | Homo sapiens (Human) | PR |
| P42696 | RBM34 | RNA-binding protein 34 | Homo sapiens (Human) | PR |
| Q05CL8 | Larp7 | La-related protein 7 | Mus musculus (Mouse) | PR |
| Q924M5 | Boll | Protein boule-like | Mus musculus (Mouse) | PR |
| Q8C854 | Myef2 | Myelin expression factor 2 | Mus musculus (Mouse) | PR |
| Q5XI01 | Larp7 | La-related protein 7 | Rattus norvegicus (Rat) | PR |
| Q9S7N9 | CID12 | Polyadenylate-binding protein-interacting protein 12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93ZV7 | LA1 | La protein 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q4KM14 | trnau1apl | tRNA selenocysteine 1-associated protein 1-like | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADADKSEAA | AGDDGSQQQP | AEPRRDTHPG | EPEKPPRSSA | NGVKMENDES | VKEEKSDLKE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KSTGNKKANR | FHPYSKDKNS | GTGEKKGPNR | NRVFISNIPY | DMKWQAIKDL | MREKVGEVTY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VELFKDAEGK | SRGCGVVEFK | DEEFVKKALE | TMNKYDLSGR | PLNIKEDPDG | ENARRALQRT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GTSFQGSHAS | DVGSGLVNLP | PSILNNPNIP | PEVISNLQAG | RLGSTIFVAN | LDFKVGWKKL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KEVFSIAGTV | KRADIKEDKD | GKSRGMGTVT | FEQAIEAVQA | ISMFNGQFLF | DRPMHVKMDD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KSVPHEDYRS | HDSKTSQLPR | GLGGIGMGLG | PGGQPISASQ | LNITGVMGNL | GPSGMGMDGP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GFGGVNRIGG | GVGFGGLEAM | NSMAGFGGVG | RMGELYRGAM | TSSMERDFGR | GDIGLSRGFG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DSFGRLGSAM | IGGFAGRIGA | SNMGPVGTGI | SGSMSGMSTV | TGGMGMGLDR | MSSSFDRMGP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GIGAILERSI | DVDRGFLSGP | MGSGMRDRLG | SKGNQIFVRN | LPFDLTWQKL | KEKFSQCGHV |
| 550 | 560 | 570 | 580 | 590 | |
| MFAEIKMENG | KSKGCGTVRF | ESAESAEKAC | RIMNGIKISG | REIDVRLDRN | A |