AiPD: Autoinhibited Protein Database

P05455

Gene name	SSB
Protein name	Lupus La protein
Names	La autoantigen, La ribonucleoprotein, Sjoegren syndrome type B antigen, SS-B
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6741
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

55-132 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

55-132 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

10 structures for P05455

Entry ID	Method	Resolution	Chain	Position	Source
1OWX	NMR	-	A	225-334	PDB
1S79	NMR	-	A	105-202	PDB
1S7A	NMR	-	A	1-103	PDB
1YTY	X-ray	229 A	A/B	1-194	PDB
1ZH5	X-ray	185 A	A/B	1-194	PDB
2VOD	X-ray	210 A	A/B	4-194	PDB
2VON	X-ray	210 A	A/B	4-194	PDB
2VOO	X-ray	180 A	A/B	4-194	PDB
2VOP	X-ray	280 A	A	4-194	PDB
AF-P05455-F1	Predicted				AlphaFoldDB

224 variants for P05455

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA1959089 rs546772759	2	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1959091 rs747161057	4	N>D		No	ClinGen ExAC TOPMed gnomAD
rs776632185 CA1959093	6	D>G		No	ClinGen ExAC gnomAD
rs1438499171 CA348875637	7	N>D		No	ClinGen gnomAD
CA348875716 rs1273050684	10	M>V		No	ClinGen gnomAD
rs146485470 CA1959094	12	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA1959095 rs367922508	13	L>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1297190319 CA348875831	15	A>S		No	ClinGen gnomAD
rs1352326179 CA348875962	19	H>Y		No	ClinGen TOPMed
rs1318082149 CA348879025	26	G>S		No	ClinGen gnomAD
CA348879052 rs1318117371	27	D>N		No	ClinGen TOPMed
CA348879113 rs1252719505	29	N>D		No	ClinGen TOPMed
CA1959115 rs769907654 COSM3787890	29	N>S	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs566356422 CA1959117	32	R>W		No	ClinGen ExAC TOPMed gnomAD
CA1959118 rs771484976	33	D>N		No	ClinGen ExAC gnomAD
rs905545381 CA59566712	34	K>R		No	ClinGen TOPMed
CA59566715 rs267599002	39	Q>H		No	ClinGen Ensembl
rs1374635098 CA348879470	39	Q>R		No	ClinGen TOPMed
CA1959119 rs774515446	41	K>T		No	ClinGen ExAC gnomAD
TCGA novel	41	K>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348879641 rs1290474636	45	G>A		No	ClinGen TOPMed gnomAD
CA59566730 rs3191574	48	P>S		No	ClinGen Ensembl
CA59566746 rs911514709	53	I>T		No	ClinGen gnomAD
CA1959122 rs532347388	53	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1358069216 CA348879934	56	N>K		No	ClinGen gnomAD
rs918728303 CA59566801	60	R>C		No	ClinGen TOPMed gnomAD
CA59566802 rs891627030 COSM1009367	60	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA348880133 rs1333146440	63	T>A		No	ClinGen gnomAD
rs1336724784 CA348880156	64	D>E		No	ClinGen gnomAD
rs774983377 CA348880199 CA1959137	66	N>K		No	ClinGen ExAC gnomAD
rs772605830 CA1959138	68	I>T		No	ClinGen ExAC TOPMed gnomAD
CA59566821 rs1009985222	71	A>V		No	ClinGen TOPMed
rs1343007959 CA348880301	73	S>G		No	ClinGen gnomAD
rs548069992 CA1959141	77	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA1959142 rs753217349	78	E>Q		No	ClinGen ExAC gnomAD
CA1959143 rs761453238	79	L>F		No	ClinGen ExAC TOPMed gnomAD
CA348880437 rs761453238	79	L>V		No	ClinGen ExAC TOPMed gnomAD
rs141623414 CA1959146	80	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs765070949 CA1959145	80	M>L		No	ClinGen ExAC TOPMed gnomAD
rs765070949 CA1959144	80	M>V		No	ClinGen ExAC TOPMed gnomAD
CA348880614 rs1439034558	84	E>D		No	ClinGen gnomAD
rs568279000 CA1959148	93	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA348880964 rs751375349	94	S>C		No	ClinGen ExAC TOPMed gnomAD
rs751375349 CA1959149	94	S>G		No	ClinGen ExAC TOPMed gnomAD
CA348881048 rs1396770481	96	P>L		No	ClinGen gnomAD
rs1159787253 CA348881030	96	P>S		No	ClinGen TOPMed
CA1959150 rs756264443	103	E>G		No	ClinGen ExAC TOPMed gnomAD
rs1400085380 CA348881411	107	D>Y		No	ClinGen gnomAD
rs749319622 CA1959152	108	V>L		No	ClinGen ExAC gnomAD
CA1959153 rs537120356	110	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA59566906 rs879196529	113	V>I		No	ClinGen Ensembl
CA1959156 rs377101371	114	Y>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA348881804 rs1220189594	115	I>M		No	ClinGen gnomAD
CA1959157 rs557065020	115	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs757444172 CA1959193	120	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1183288270 CA348882409	121	D>G		No	ClinGen gnomAD
rs887376306 CA59567510	121	D>Y		No	ClinGen Ensembl
rs1236503677 CA348882458	122	A>G		No	ClinGen TOPMed
CA348882555 rs1254474557	125	D>N		No	ClinGen gnomAD
CA1959194 rs372066287	127	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA348882660 rs1558971269	127	I>R		No	ClinGen Ensembl
TCGA novel	129	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1959195 rs200789540	131	L>I		No	ClinGen ExAC TOPMed gnomAD
rs1392147580 CA348882897	133	D>E		No	ClinGen TOPMed
rs1558971287 CA348882877	133	D>N		No	ClinGen Ensembl
rs1573960351 CA348882931	135	G>C		No	ClinGen Ensembl
rs147074057 CA1959196	136	Q>*		No	ClinGen ESP ExAC gnomAD
rs1359864396 CA348882972	137	V>I		No	ClinGen gnomAD
rs747558417 CA1959198	140	I>T		No	ClinGen ExAC gnomAD
rs376401398 CA1959199	147	H>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA1959200 rs376401398	147	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs546270676 CA1959201	149	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA348883335 rs546270676	149	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1959202 rs769419286	150	F>S		No	ClinGen ExAC gnomAD
TCGA novel	151	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	152	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1311333446 CA348883600	153	S>T		No	ClinGen gnomAD
CA348883630 rs1558971367	154	I>T		No	ClinGen Ensembl
CA348883619 rs1469063925	154	I>V		No	ClinGen gnomAD
CA348883680 rs1278992679	155	F>L		No	ClinGen TOPMed
TCGA novel	162	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs12467132 CA59567675	164	A>D		No	ClinGen Ensembl
rs1402256361 CA348883903	164	A>S		No	ClinGen TOPMed gnomAD
rs760452732 CA1959214	166	K>E		No	ClinGen ExAC gnomAD
CA348884055 rs1330673910	168	V>I		No	ClinGen gnomAD
CA1959217 rs186344908	171	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA59567693 rs369947209	178	T>A		No	ClinGen ESP gnomAD
CA1959219 rs751610012	179	D>E		No	ClinGen ExAC gnomAD
rs753095047 CA1959222	182	I>T		No	ClinGen ExAC gnomAD
CA348884436 rs1253703360	183	L>F		No	ClinGen TOPMed gnomAD
CA1959223 rs756488413	184	F>L		No	ClinGen ExAC gnomAD
CA348885640 rs1162673929	187	D>N		No	ClinGen TOPMed gnomAD
rs1364389649 CA348885714	188	Y>C		No	ClinGen gnomAD
CA348885814 COSM1009370 rs1419788745	191	K>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs753297385	193	N>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs753297385	193	N>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA348885924 rs1573961460	194	E>G		No	ClinGen Ensembl
rs1338004524 CA348885947	195	E>G		No	ClinGen gnomAD
CA1959249 rs745368217	196	R>G		No	ClinGen ExAC gnomAD
CA59568691 rs143377617 COSM106601	196	R>K	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
COSM108293 CA59568705 rs146255324	198	Q>K	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
rs139396181 COSM109894 CA59568713	199	N>K	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
TCGA novel	201	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1170235931 CA348886246	207	A>G		No	ClinGen gnomAD
rs779383125 CA1959271	209	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1227101487 CA348886295	209	Q>K		No	ClinGen gnomAD
CA59568967 rs940739370	210	E>Q		No	ClinGen TOPMed
rs139144686 CA1959272	210	E>V		No	ClinGen ESP ExAC gnomAD
CA1959273 rs754892743	211	Q>*		No	ClinGen ExAC gnomAD
CA59568990 rs866315535	213	A>T		No	ClinGen Ensembl
CA1959276 rs747940610	215	Q>E		No	ClinGen ExAC gnomAD
CA1959277 rs76002866	217	L>S		No	ClinGen 1000Genomes ESP TOPMed gnomAD
rs1377932338 CA348886702	218	E>Q		No	ClinGen gnomAD
CA1959279 rs145573186	219	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs142716482 CA1959280	220	D>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs368954177 CA1959281	221	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs772353316 CA1959282	222	E>D		No	ClinGen ExAC gnomAD
CA348886836 rs1336518068	223	M>T		No	ClinGen gnomAD
CA1959324 rs768885266	226	L>Q		No	ClinGen ExAC gnomAD
rs201142063 CA1959323	226	L>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA1959325 rs781186776	227	E>Q		No	ClinGen ExAC gnomAD
CA1959326 rs748264074	229	K>R		No	ClinGen ExAC gnomAD
CA59570378 rs374153062	232	C>Y		No	ClinGen ESP TOPMed gnomAD
rs773826217 CA1959328	237	S>L		No	ClinGen ExAC TOPMed
CA348888639 rs1444030710	241	D>G		No	ClinGen gnomAD
CA348888622 rs1291798115	241	D>N		No	ClinGen TOPMed
rs771385009 CA1959330	244	T>I		No	ClinGen ExAC gnomAD
rs1247538983 CA348888741	246	R>G		No	ClinGen TOPMed
rs4813 CA59570413	247	E>G		No	ClinGen ESP TOPMed
rs4813 CA59570414	247	E>V		No	ClinGen ESP TOPMed
CA1959331 rs774879990	248	D>N		No	ClinGen ExAC gnomAD
rs1296401220 CA348888824	250	H>Y		No	ClinGen TOPMed
CA1959333 rs767282588	251	I>V		No	ClinGen ExAC gnomAD
CA348889091 rs571911479	258	E>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs763919441 CA1959336	258	E>D		No	ClinGen ExAC TOPMed gnomAD
rs571911479 CA1959335	258	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1309326051 CA348889293	265	V>I		No	ClinGen TOPMed gnomAD
TCGA novel	269	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1028236877 CA348889406	270	E>*		No	ClinGen gnomAD
rs1028236877 CA59570469	270	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	271	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1323344081 CA348889703	274	L>V		No	ClinGen gnomAD
CA1959349 rs746301438	276	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1029985868 CA59570906	282	A>T		No	ClinGen TOPMed
CA348890182 rs1176724563	283	L>F		No	ClinGen gnomAD
CA348890246 rs1268198088	284	G>V		No	ClinGen gnomAD
CA1959351 rs775265757	287	K>R		No	ClinGen ExAC gnomAD
rs763617054 CA1959353	289	A>E		No	ClinGen ExAC gnomAD
rs776024514 CA348890550	292	G>A		No	ClinGen ExAC TOPMed gnomAD
CA1959354 rs776024514	292	G>D		No	ClinGen ExAC TOPMed gnomAD
rs761677581 CA348890755	297	R>S		No	ClinGen ExAC gnomAD
rs143840972 CA1959356	298	N>K		No	ClinGen ESP ExAC gnomAD
rs750214755 CA1959357	300	E>V		No	ClinGen ExAC gnomAD
rs989775196 CA59571013	305	V>I		No	ClinGen Ensembl
CA1959359 rs767702957	306	L>I		No	ClinGen ExAC gnomAD
CA1959360 rs533896111	307	E>G		No	ClinGen 1000Genomes ExAC gnomAD
rs1260510662 CA348891031	310	V>M		No	ClinGen gnomAD
CA348891047 rs1268095950	311	E>G		No	ClinGen TOPMed
rs777720784 CA1959361	312	K>E		No	ClinGen ExAC gnomAD
rs777853278 CA1959362	313	E>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA348891078 rs1204501885	313	E>K		No	ClinGen gnomAD
CA1959364 rs757835858	314	A>V		No	ClinGen ExAC gnomAD
CA348891145 rs1197455395	316	K>R		No	ClinGen gnomAD
CA348891277 rs1268463610	319	I>M		No	ClinGen gnomAD
rs1194154895 CA348891348	320	E>D		No	ClinGen gnomAD
rs1421436926 CA348891359	321	D>Y		No	ClinGen gnomAD
TCGA novel	326	L>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348891563 rs1308312482	327	N>K		No	ClinGen TOPMed
rs1573963390 CA348891628	329	W>R		No	ClinGen Ensembl
CA1959381 rs760886261	334	R>C		No	ClinGen ExAC TOPMed gnomAD
CA348891958 rs760886261	334	R>G		No	ClinGen ExAC TOPMed gnomAD
CA1959382 rs761080670	334	R>H		No	ClinGen ExAC gnomAD
rs753941499 CA1959383	335	R>S		No	ClinGen ExAC TOPMed gnomAD
CA348891993 rs1573963543	335	R>T		No	ClinGen Ensembl
CA1959386 rs757465425	337	K>T		No	ClinGen ExAC gnomAD
rs1244472114 CA348892237	341	K>R		No	ClinGen gnomAD
rs1314437256 CA348892248	342	G>D		No	ClinGen gnomAD
CA348892244 rs1284349421	342	G>S		No	ClinGen TOPMed
TCGA novel	343	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348892356 rs1304156691	344	K>N		No	ClinGen TOPMed
CA348892347 rs1349178116	344	K>T		No	ClinGen TOPMed
TCGA novel	346	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348892413 rs1558973597	346	A>V		No	ClinGen Ensembl
CA348892439 rs1558973605	347	Q>H		No	ClinGen Ensembl
CA1959387 rs370543439	347	Q>P		No	ClinGen ESP ExAC gnomAD
rs370543439 CA1959388	347	Q>R		No	ClinGen ESP ExAC gnomAD
rs1390297049 CA348892461	349	G>R		No	ClinGen TOPMed
rs374202019 CA59571188	349	G>V		No	ClinGen ESP TOPMed
CA1959389 rs758993474	352	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA1959390 rs780405113	354	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1237885774 CA348892704	356	Q>H		No	ClinGen gnomAD
CA348892691 rs1255649253	356	Q>P		No	ClinGen gnomAD
CA1959393 rs747335133	359	G>S		No	ClinGen ExAC TOPMed gnomAD
rs780764356 CA1959396	362	T>K		No	ClinGen ExAC TOPMed gnomAD
CA1959395 rs780764356	362	T>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	366	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1177202454 CA348892950	366	S>T		No	ClinGen gnomAD
rs762821643 CA1959400	367	D>E		No	ClinGen ExAC gnomAD
CA1959399 rs772739645	367	D>G		No	ClinGen ExAC gnomAD
rs1558973669 CA348892963	367	D>H		No	ClinGen Ensembl
CA1959401 rs377472931	368	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1377650498 CA348893027	369	E>K		No	ClinGen gnomAD
rs1053269262 CA59571245	370	H>N		No	ClinGen TOPMed
CA59571253 rs901363673	370	H>R		No	ClinGen TOPMed
rs1350265055 CA348893094	371	D>G		No	ClinGen gnomAD
rs575866793 CA1959403	372	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1959404 rs759308232	373	H>Y		No	ClinGen ExAC gnomAD
CA59571268 rs934249542	374	D>N		No	ClinGen TOPMed
rs1201618687 CA348893170	375	E>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA1959405 rs139847090	375	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1201618687 CA348893175	375	E>V		No	ClinGen TOPMed gnomAD
rs1308557439 CA348893281	379	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs762159811 CA1959407	380	G>R		No	ClinGen ExAC TOPMed gnomAD
CA348894333 rs1358250965	381	P>S		No	ClinGen TOPMed gnomAD
CA1959430 rs150765079	387	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA1959431 rs773416649	389	T>K		No	ClinGen ExAC gnomAD
CA348894476 rs1338105682	391	K>R		No	ClinGen gnomAD
CA1959435 rs766886435	395	A>T		No	ClinGen ExAC gnomAD
rs752046045 CA1959436	399	Q>K		No	ClinGen ExAC gnomAD
CA59571641 rs758688051	401	T>I		No	ClinGen gnomAD
CA1959439 rs753066667	407	D>H		No	ClinGen ExAC gnomAD
rs957310075 CA348894788	408	Q>*		No	ClinGen gnomAD
rs957310075 CA59571648	408	Q>K		No	ClinGen gnomAD
CA1959441 rs777460087	408	Q>P		No	ClinGen ExAC gnomAD

No associated diseases with P05455

3 regional properties for P05455

Type	Name	Position	InterPro Accession
domain	RNA recognition motif domain	111 - 187	IPR000504
domain	La-type HTH domain	7 - 99	IPR006630
domain	La protein, xRRM domain	227 - 348	IPR014886

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
chromosome, telomeric region	The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribonucleoprotein complex	A macromolecular complex that contains both RNA and protein molecules.

6 GO annotations of molecular function

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
mRNA binding	Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
poly(U) RNA binding	Binding to a sequence of uracil residues in an RNA molecule.
RNA binding	Binding to an RNA molecule or a portion thereof.
sequence-specific mRNA binding	Binding to messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif.
tRNA binding	Binding to a transfer RNA.

9 GO annotations of biological process

Name	Definition
histone mRNA metabolic process	The chemical reactions and pathways involving an mRNA encoding a histone.
IRES-dependent viral translational initiation	Process by which viral mRNA translation is initiated, where a domain in the 5' untranslated region (UTR) of the viral mRNA called an internal ribosome entry site (IRES) binds the host 43S preinitiation complex, circumventing regular cap-dependent translation initiation.
nuclear histone mRNA catabolic process	The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA) within the nucleus.
protein localization to cytoplasmic stress granule	A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule.
tRNA 3'-end processing	The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA.
tRNA 5'-leader removal	Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P.
tRNA export from nucleus	The directed movement of tRNA from the nucleus to the cytoplasm.
tRNA modification	The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.
tRNA processing	The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

6 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q4G0J3	LARP7	La-related protein 7	Homo sapiens (Human)	PR
Q71RC2	LARP4	La-related protein 4	Homo sapiens (Human)	PR
Q6PKG0	LARP1	La-related protein 1	Homo sapiens (Human)	PR
Q659C4	LARP1B	La-related protein 1B	Homo sapiens (Human)	PR
Q05CL8	Larp7	La-related protein 7	Mus musculus (Mouse)	PR
Q93ZV7	LA1	La protein 1	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MAENGDNEKM	AALEAKICHQ	IEYYFGDFNL	PRDKFLKEQI	KLDEGWVPLE	IMIKFNRLNR
70	80	90	100	110	120
LTTDFNVIVE	ALSKSKAELM	EISEDKTKIR	RSPSKPLPEV	TDEYKNDVKN	RSVYIKGFPT
130	140	150	160	170	180
DATLDDIKEW	LEDKGQVLNI	QMRRTLHKAF	KGSIFVVFDS	IESAKKFVET	PGQKYKETDL
190	200	210	220	230	240
LILFKDDYFA	KKNEERKQNK	VEAKLRAKQE	QEAKQKLEED	AEMKSLEEKI	GCLLKFSGDL
250	260	270	280	290	300
DDQTCREDLH	ILFSNHGEIK	WIDFVRGAKE	GIILFKEKAK	EALGKAKDAN	NGNLQLRNKE
310	320	330	340	350	360
VTWEVLEGEV	EKEALKKIIE	DQQESLNKWK	SKGRRFKGKG	KGNKAAQPGS	GKGKVQFQGK
370	380	390	400
KTKFASDDEH	DEHDENGATG	PVKRAREETD	KEEPASKQQK	TENGAGDQ