AiPD: Autoinhibited Protein Database

Q71RC2

Gene name	LARP4 (PP13296)
Protein name	La-related protein 4
Names	La ribonucleoprotein domain family member 4
Species	Homo sapiens (Human)
KEGG Pathway	hsa:113251
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

391-500 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

391-500 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for Q71RC2

Entry ID	Method	Resolution	Chain	Position	Source
2CQK	NMR	-	A	113-200	PDB
3PKN	X-ray	180 A	B	13-26	PDB
6I9B	NMR	-	A	111-287	PDB
AF-Q71RC2-F1	Predicted				AlphaFoldDB

499 variants for Q71RC2

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1469241927 CA384816312	2	L>F		No	ClinGen TOPMed gnomAD
TCGA novel	3	L>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs377730344 CA6563497	4	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs772183477 CA6563496	4	F>Y		No	ClinGen ExAC gnomAD
CA6563498 rs201028627	5	V>M		No	ClinGen 1000Genomes ExAC gnomAD
CA384816331 rs1197583403	6	E>K		No	ClinGen gnomAD
CA6563524 rs146142861	9	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs146142861 CA236772636	9	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA236772654 rs948280281	11	K>*		No	ClinGen Ensembl
rs767218428 TCGA novel CA6563526	11	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen ExAC TOPMed gnomAD
rs761470805 CA6563525	11	K>T		No	ClinGen ExAC
rs1229510474 CA384816965	14	G>S		No	ClinGen TOPMed
rs1352962187 CA384816972	15	L>V		No	ClinGen TOPMed
CA384816991 rs1296207965	17	P>H		No	ClinGen gnomAD
CA6563528 rs760222423	20	K>T		No	ClinGen ExAC gnomAD
CA384817013 rs1253930124	21	V>I		No	ClinGen gnomAD
rs1043969698 CA236772725	26	A>V		No	ClinGen Ensembl
TCGA novel	29	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA384817072 rs1209151931	29	N>S		No	ClinGen gnomAD
rs1249738250 CA384817080	30	T>I		No	ClinGen gnomAD
rs199674991 CA236772737	31	D>H		No	ClinGen Ensembl
CA384817092 rs1463498908	32	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA384817102 rs753837725	34	P>A		No	ClinGen ExAC gnomAD
rs754689963 CA6563531	34	P>L		No	ClinGen ExAC gnomAD
CA6563530 rs753837725	34	P>S		No	ClinGen ExAC gnomAD
rs751771966 CA6563533	35	V>I		No	ClinGen ExAC gnomAD
CA384817120 rs1377318584	37	H>R		No	ClinGen gnomAD
rs935475317 CA236772785	38	G>R		No	ClinGen Ensembl
rs757537792 CA6563534	41	S>N		No	ClinGen ExAC TOPMed gnomAD
CA236772793 rs370676327	42	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA
rs1322986534 COSM468491 CA384817156	43	W>R	kidney [Cosmic]	No	ClinGen cosmic curated gnomAD
CA384817169 rs1386979214	44	H>L		No	ClinGen TOPMed gnomAD
rs1386979214 CA384817168	44	H>R		No	ClinGen TOPMed gnomAD
rs745911828 CA6563536	46	I>T		No	ClinGen ExAC gnomAD
CA6563535 rs781628490	46	I>V		No	ClinGen ExAC gnomAD
CA384817189 rs1273960935	47	A>G		No	ClinGen Ensembl
rs1367663563 CA384817185	47	A>T		No	ClinGen gnomAD
rs756263092 CA6563537	48	A>P		No	ClinGen ExAC gnomAD
CA6563538 rs140187240	49	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6563539 rs749830137	49	T>I		No	ClinGen ExAC TOPMed gnomAD
rs749830137 CA384817199	49	T>R		No	ClinGen ExAC TOPMed gnomAD
rs368233624 CA6563540	51	G>V		No	ClinGen ESP ExAC TOPMed
CA6563541 rs774688114	52	A>G		No	ClinGen ExAC gnomAD
CA6563542 rs748581555	53	H>R		No	ClinGen ExAC TOPMed gnomAD
CA236772869 rs371940413	53	H>Y		No	ClinGen ESP TOPMed gnomAD
rs200311098 CA6563543	56	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs779439702 CA6563561	57	N>D		No	ClinGen ExAC gnomAD
rs1309427853 CA384817388	61	S>L		No	ClinGen gnomAD
CA6563564 rs772813238	62	E>K		No	ClinGen ExAC TOPMed gnomAD
CA384817405 rs1441141360	63	D>H		No	ClinGen gnomAD
CA6563565 rs746679880	63	D>V		No	ClinGen ExAC gnomAD
rs541317273 CA6563568	64	I>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA236774077 rs541317273	64	I>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs541317273 CA6563567	64	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1476634625 CA384817517	70	V>G		No	ClinGen TOPMed
CA6563569 rs769822581	71	M>R		No	ClinGen ExAC TOPMed gnomAD
CA6563571 rs775618096	75	S>F		No	ClinGen ExAC gnomAD
CA6563572 rs762786792	76	C>S		No	ClinGen ExAC TOPMed gnomAD
rs762786792 CA6563573	76	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs750605740 CA6563574	78	T>N		No	ClinGen ExAC gnomAD
rs375805371 CA6563575	79	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs375805371 CA6563576	79	T>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA6563579 rs779344035	80	R>I		No	ClinGen ExAC gnomAD
rs1181739914 CA384817656	81	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs753238473 CA6563580	82	T>I		No	ClinGen ExAC TOPMed gnomAD
rs758699442 CA6563581	83	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1346805584 CA384817708	85	I>T		No	ClinGen TOPMed
CA384817758 rs1169956192	89	T>A		No	ClinGen gnomAD
rs1409009576 CA384817783	91	G>R		No	ClinGen gnomAD
COSM358699 CA6563584 rs747392424 CA6563583	92	M>I	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1360658488 CA384817798	92	M>V		No	ClinGen gnomAD
rs1411987795 CA384817832	95	G>R		No	ClinGen TOPMed
CA6563585 rs780745502	100	S>C		No	ClinGen ExAC gnomAD
CA384817870 rs780745502	100	S>G		No	ClinGen ExAC gnomAD
rs745357845 CA6563586	101	Y>C		No	ClinGen ExAC gnomAD
CA384817899 rs1338896464	102	Q>E		No	ClinGen gnomAD
rs558066547 CA6563587	105	D>N		No	ClinGen 1000Genomes ExAC gnomAD
CA384817964 rs1209862636	106	V>G		No	ClinGen gnomAD
CA384817966 rs1249132771	107	S>A		No	ClinGen gnomAD
CA6563611 rs774205855	110	S>G		No	ClinGen ExAC gnomAD
CA384818197 rs1260578384	111	N>S		No	ClinGen gnomAD
CA6563612 rs747927894	114	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1212210601 CA384818222	115	S>F		No	ClinGen gnomAD
rs142269189 CA6563613	116	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6563615 rs759770835	116	T>I		No	ClinGen ExAC gnomAD
rs142269189 CA6563614	116	T>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA384818231 rs1252130456	117	E>G		No	ClinGen gnomAD
CA384818239 rs1473413238	118	D>V		No	ClinGen gnomAD
CA6563620 rs752025559	122	C>Y		No	ClinGen ExAC gnomAD
rs757597872 CA6563621	123	L>P		No	ClinGen ExAC gnomAD
CA384818293 rs1424126982	126	Q>K		No	ClinGen gnomAD
CA6563624 rs370261750 CA384818312	128	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA384818317 rs1358507376	129	F>S		No	ClinGen TOPMed gnomAD
CA384818344 rs1408322438	133	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA384818345 rs1306719325	133	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	134	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6563645 rs774854357 COSM416214	136	L>F	urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA236780810 rs970894460	138	K>Q		No	ClinGen TOPMed
TCGA novel	140	L>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	141	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA384818661 rs1309862165	142	L>F		No	ClinGen TOPMed
CA384818668 rs1224768549	143	I>M		No	ClinGen gnomAD
rs977935863 CA236780817	143	I>V		No	ClinGen TOPMed gnomAD
CA6563646 rs762238929	145	Q>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA384818699 rs1483433932	148	S>G		No	ClinGen gnomAD
rs750812094 CA6563649	150	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1189213980 CA384818737	153	P>T		No	ClinGen gnomAD
CA384818744 rs1392065755	154	I>V		No	ClinGen gnomAD
CA384818752 rs1175446913	155	W>G		No	ClinGen TOPMed
CA6563652 rs753577735	155	W>S		No	ClinGen ExAC gnomAD
CA384818759 rs1378429954	156	T>A		No	ClinGen gnomAD
CA384818785 rs1467850082 COSM1639148	160	M>V	stomach [Cosmic]	No	ClinGen cosmic curated gnomAD
TCGA novel	166	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA384818846 rs754471636 COSM548703	168	T>A	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs754471636 CA6563653	168	T>S		No	ClinGen ExAC gnomAD
CA384818854 rs1457522009	169	D>G		No	ClinGen TOPMed
rs778303791 CA6563654	170	P>A		No	ClinGen ExAC gnomAD
CA236780887 CA384818869 rs989389169	171	D>E		No	ClinGen TOPMed gnomAD
rs1366683136 CA384818888	175	E>K		No	ClinGen gnomAD
rs1418394879 CA384818896	176	V>M		No	ClinGen TOPMed
CA384818915 rs1380061657	178	R>S		No	ClinGen gnomAD
CA384819153 rs1266078613	181	P>A		No	ClinGen gnomAD
rs78631494 CA6563680	182	M>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6563681 rs78631494	182	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6563682 rs780977801	187	E>K		No	ClinGen ExAC gnomAD
CA6563685 rs768753799	189	G>C		No	ClinGen ExAC TOPMed gnomAD
rs768753799 CA6563684	189	G>S		No	ClinGen ExAC TOPMed gnomAD
CA236783449 rs200185443	192	V>A		No	ClinGen TOPMed
rs375971492 CA6563686	196	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1418998899 CA384819315	198	R>H		No	ClinGen gnomAD
TCGA novel	200	I>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772226829 CA6563687	200	I>V		No	ClinGen ExAC TOPMed gnomAD
CA6563689 rs773788540	208	E>K		No	ClinGen ExAC gnomAD
CA6563690 rs761278563	209	T>A		No	ClinGen ExAC gnomAD
CA6563692 rs201686100	212	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA384820060 rs1183558422	216	K>E		No	ClinGen gnomAD
CA236786142 rs777330525	217	G>A		No	ClinGen ExAC TOPMed gnomAD
CA6563714 rs777330525	217	G>D		No	ClinGen ExAC TOPMed gnomAD
CA384820080 rs1169248383	219	F>L		No	ClinGen gnomAD
rs1254385705 CA384820097	221	S>N		No	ClinGen TOPMed
CA6563715 rs369661355 CA384820116	223	N>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA384820126 rs1408107893	225	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1047085836 CA236786163	227	V>M		No	ClinGen TOPMed
CA384820151 rs1336052490	229	S>R		No	ClinGen gnomAD
CA236786169 rs994204824	232	F>L		No	ClinGen TOPMed gnomAD
CA236786174 rs888419312	235	N>S		No	ClinGen TOPMed
CA6563721 rs761350873	237	N>S		No	ClinGen ExAC gnomAD
CA384820219 rs1328467123	238	W>R		No	ClinGen TOPMed
TCGA novel	242	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1273734374 CA384820283	246	T>I		No	ClinGen TOPMed
rs1008258563 CA236787076	255	L>F		No	ClinGen TOPMed
CA384820397 rs1341161531	255	L>V		No	ClinGen gnomAD
CA236787100 rs375893849	256	R>K		No	ClinGen ESP TOPMed gnomAD
rs1039294577 CA236787101	258	E>D		No	ClinGen TOPMed
TCGA novel	263	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs540112594 CA236787110	263	Q>R		No	ClinGen 1000Genomes
TCGA novel	264	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774037968 CA6563741	267	I>V		No	ClinGen ExAC TOPMed gnomAD
CA384821407 rs1399019945	271	I>K		No	ClinGen gnomAD
CA384821406 rs1469344529	271	I>V		No	ClinGen TOPMed
CA384821426 rs1390056703	274	I>V		No	ClinGen gnomAD
CA384821436 rs1328691507	275	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA384821456 rs1255427393	278	F>V		No	ClinGen TOPMed
TCGA novel	280	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1004285132 CA236796800	281	N>D		No	ClinGen TOPMed
CA384821483 rs1341604657	282	G>S		No	ClinGen gnomAD
CA6563760 rs771680507	290	I>V		No	ClinGen ExAC TOPMed gnomAD
CA384821550 rs1244724910	291	Y>C		No	ClinGen gnomAD
CA236796803 rs957659476	293	H>Q		No	ClinGen Ensembl
CA6563762 rs760146452	294	P>L		No	ClinGen ExAC TOPMed gnomAD
CA6563761 rs370399330	294	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA236796827 rs988930174	295	I>V		No	ClinGen TOPMed gnomAD
CA6563763 rs770883830	300	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs770883830 CA6563764	300	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA6563765 rs759368478	302	A>T		No	ClinGen ExAC TOPMed gnomAD
CA6563766 rs765125087	303	S>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	303	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1375004043 CA384821668	309	P>T		No	ClinGen gnomAD
CA384821678 rs1407819020	310	V>A		No	ClinGen TOPMed
COSM3739713 CA6563767 rs751771927	311	Y>C	liver [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1361739596 CA384821688	312	N>D		No	ClinGen gnomAD
TCGA novel	313	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1403436660 CA384821707	314	H>Q		No	ClinGen gnomAD
CA6563768 rs762110345	315	Q>P		No	ClinGen ExAC gnomAD
rs762110345 CA384821712	315	Q>R		No	ClinGen ExAC gnomAD
rs1379892195 CA384821733	318	S>A		No	ClinGen gnomAD
CA6563770 rs200920592	318	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6563771 rs201761805	319	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs971599267 CA236796911	320	Y>C		No	ClinGen TOPMed gnomAD
rs981708446 CA236796919	321	S>N		No	ClinGen TOPMed
CA384821760 rs1250523374	322	I>T		No	ClinGen gnomAD
CA384821779 rs1387608336	325	Q>R		No	ClinGen gnomAD
rs1303705101 CA384821819	331	P>A		No	ClinGen gnomAD
rs375407142 CA6563773	332	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA6563775 rs201409653	333	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA384821836 rs1272552209	334	Y>D		No	ClinGen TOPMed
CA384821851 rs1230797654	336	E>Q		No	ClinGen gnomAD
CA6563777 rs371625011	337	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs771728085 CA6563778	338	P>S		No	ClinGen ExAC gnomAD
rs766384339 CA6563791	340	A>P		No	ClinGen ExAC TOPMed gnomAD
CA384821902 rs1409401460	342	F>L		No	ClinGen TOPMed
rs1481589594 CA384821904	343	P>T		No	ClinGen gnomAD
CA6563793 rs755473780	344	N>S		No	ClinGen ExAC gnomAD
rs753976983 CA6563792	344	N>Y		No	ClinGen ExAC gnomAD
rs368192050 CA6563794	346	S>T		No	ClinGen ESP ExAC
rs74623055 CA236797595	348	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6563795 rs74623055	348	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	349	N>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6563796 rs17124706 VAR_055936	351	F>L		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs777446576 CA6563797	353	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1454913593 CA384822006	354	P>L		No	ClinGen TOPMed
rs756730225 CA6563799	355	G>R		No	ClinGen ExAC gnomAD
rs369863425 CA236797600	356	S>A		No	ClinGen ESP TOPMed gnomAD
CA236797603 rs866906397	356	S>F		No	ClinGen Ensembl
TCGA novel	359	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs372889084 CA6563801	360	N>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1565683772 CA384822070	360	N>S		No	ClinGen Ensembl
CA384822081 rs1593277748	361	A>G		No	ClinGen Ensembl
rs868265535 CA236797612	363	A>S		No	ClinGen Ensembl
CA384822109 rs1440979781	364	M>T		No	ClinGen TOPMed
CA6563803 rs775616209	364	M>V		No	ClinGen ExAC TOPMed gnomAD
rs749060996 CA384822162	368	R>P		No	ClinGen ExAC TOPMed gnomAD
CA6563805 rs749060996	368	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA6563806 rs768367207	369	P>A		No	ClinGen ExAC gnomAD
rs369005701 CA6563807	370	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs372731812 CA236797643	373	N>D		No	ClinGen ESP
rs1179425728	373	N>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA384822232 rs1406435935	374	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs567199331 CA236797645	374	R>H		No	ClinGen Ensembl
CA236802682 rs989019765	377	P>L		No	ClinGen TOPMed gnomAD
rs1480591174 CA384822626	379	F>L		No	ClinGen gnomAD
rs780099369 CA6563822	380	R>K		No	ClinGen ExAC TOPMed gnomAD
rs768697912 CA6563824	382	S>A		No	ClinGen ExAC gnomAD
rs768697912 CA384822639	382	S>T		No	ClinGen ExAC gnomAD
CA384822649 rs1221674574	383	G>D		No	ClinGen TOPMed gnomAD
rs1410239744 CA384822650	384	G>S		No	ClinGen TOPMed gnomAD
CA384822677 rs1352583954	387	H>Q		No	ClinGen gnomAD
rs1292799616 CA384822681	388	S>L		No	ClinGen TOPMed
rs748018488 CA6563826	388	S>P		No	ClinGen ExAC gnomAD
rs371027233 CA6563827	389	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA384822683 rs371027233	389	T>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA384822688 rs1328225707	390	E>K		No	ClinGen TOPMed
CA384822699 rs1385027473	391	G>D		No	ClinGen gnomAD
rs759574517 CA236802733	392	S>C		No	ClinGen ExAC gnomAD
rs759574517 CA6563829	392	S>F		No	ClinGen ExAC gnomAD
rs776863677 CA6563828	392	S>P		No	ClinGen ExAC TOPMed gnomAD
CA6563832 rs763351976	395	L>S		No	ClinGen ExAC gnomAD
rs376206501 CA6563833	396	G>R		No	ClinGen ESP ExAC gnomAD
CA384822759 rs1204812849	397	D>A		No	ClinGen gnomAD
CA384822775 rs1462221049	399	Q>K		No	ClinGen gnomAD
CA384822782 rs1181198826	399	Q>R		No	ClinGen TOPMed gnomAD
rs377340378 CA6563836	403	Y>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA6563838 rs755619174	406	R>S		No	ClinGen ExAC TOPMed gnomAD
CA6563839 rs370323231	408	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs530201797 COSM371026 CA6563841	409	P>A	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA236802763 rs549517796	409	P>L		No	ClinGen Ensembl
rs1468223852 CA384822917	410	A>T		No	ClinGen gnomAD
rs375041452 CA6563843	411	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs367988641 CA6563845	412	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA6563844 rs771888389	412	R>W		No	ClinGen ExAC TOPMed gnomAD
CA6563846 rs547081047	413	H>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1289830461 CA384822968	414	N>K		No	ClinGen TOPMed
CA384822977 rs1340251091	415	P>L		No	ClinGen gnomAD
rs1196829830 CA384822973	415	P>T		No	ClinGen TOPMed
CA236802784 rs1042081836	420	H>Q		No	ClinGen Ensembl
CA236802795 rs567741000	422	E>G		No	ClinGen ExAC gnomAD
rs566991372 CA6563850	422	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6563851 rs567741000	422	E>V		No	ClinGen ExAC gnomAD
CA384823096 rs1167075221	426	L>F		No	ClinGen gnomAD
rs1217439495 CA384823136	429	E>K		No	ClinGen gnomAD
CA384823153 rs1240002563	430	T>N		No	ClinGen gnomAD
CA384823165 rs1305401614	431	S>C		No	ClinGen TOPMed
rs767998240 CA6563853	437	Q>R		No	ClinGen ExAC gnomAD
rs201082833 CA384823249	438	N>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201082833 CA6563854	438	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1479399817 CA384823254	439	G>R		No	ClinGen gnomAD
rs1408750702 CA384823283	441	Y>C		No	ClinGen TOPMed gnomAD
TCGA novel	441	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6563858 rs754539713	443	R>G		No	ClinGen ExAC gnomAD
CA384823325 rs1393781050	445	R>K		No	ClinGen TOPMed
rs1593371706 CA384823354	447	T>S		No	ClinGen Ensembl
CA384823374 rs1209037766	450	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1251055740 CA384823382	451	G>D		No	ClinGen TOPMed gnomAD
rs372217208 CA6563892	452	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA6563891 rs372217208	452	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA6563893 rs748279624	452	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1445347191 CA384823395	454	R>*		No	ClinGen gnomAD
rs375470659 CA384823396	454	R>L		No	ClinGen ESP TOPMed gnomAD
rs375470659 CA236803675	454	R>Q		No	ClinGen ESP TOPMed gnomAD
CA6563895 rs772685651 COSM940363	455	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs773880201 CA6563896	456	E>D		No	ClinGen ExAC
rs771333693 CA6563898	459	R>T		No	ClinGen ExAC TOPMed gnomAD
CA384823434 rs1408693701	460	I>T		No	ClinGen gnomAD
CA236803721 rs1043750286	460	I>V		No	ClinGen gnomAD
rs1236024936 CA384823455	462	R>G		No	ClinGen TOPMed
rs1193379691 CA384823462	463	P>T		No	ClinGen TOPMed gnomAD
CA236806152 rs201492759	464	H>R		No	ClinGen 1000Genomes gnomAD
CA384823476 rs1481692284	465	P>A		No	ClinGen gnomAD
rs1174601470 CA384823479	465	P>R		No	ClinGen gnomAD
CA384823484 rs1376290504	466	S>L		No	ClinGen gnomAD
rs774214753 CA6563926	467	T>I		No	ClinGen ExAC TOPMed gnomAD
rs996091753 CA236806162	468	A>G		No	ClinGen TOPMed
rs1289025094 CA384823508	470	S>*		No	ClinGen gnomAD
CA6563928 rs375232209	472	A>S		No	ClinGen ExAC TOPMed gnomAD
COSM295393 CA6563929 rs749476328	472	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1278370858 CA384823534	474	T>I		No	ClinGen TOPMed gnomAD
rs1241050528 CA384823537	475	P>S		No	ClinGen TOPMed
CA384823565 rs1379165765	479	L>I		No	ClinGen TOPMed
rs758496893 CA6563933	481	A>D		No	ClinGen ExAC gnomAD
rs758496893 CA384823583	481	A>V		No	ClinGen ExAC gnomAD
TCGA novel	483	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6563934 rs201955736	486	P>S		No	ClinGen ExAC gnomAD
rs751661033 CA6563935	488	P>H		No	ClinGen ExAC TOPMed gnomAD
CA384823627 rs751661033	488	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1262629400 CA384823630	489	G>R		No	ClinGen gnomAD
rs757755491 CA384823655	493	R>G		No	ClinGen ExAC TOPMed gnomAD
CA6563937 rs781594961	494	M>R		No	ClinGen ExAC gnomAD
CA384823664 rs1216222883	494	M>V		No	ClinGen gnomAD
CA384823681 rs1394462618	496	G>V		No	ClinGen TOPMed
rs143065665 CA6563939	498	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs748951248 CA6563941	499	V>I		No	ClinGen ExAC TOPMed gnomAD
CA6563943 rs371444659	500	L>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6563945 rs755045538	502	N>D		No	ClinGen ExAC TOPMed gnomAD
rs17124715 CA384823715	502	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
VAR_055937 CA6563946 rs17124715	502	N>T		No	ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
rs755045538 CA6563944	502	N>Y		No	ClinGen ExAC TOPMed gnomAD
CA384823743 rs1365924799	506	D>Y		No	ClinGen TOPMed gnomAD
CA6563947 rs374829101	507	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA384823784 rs1291656032	512	Y>C		No	ClinGen gnomAD
CA384823785 rs1291656032	512	Y>F		No	ClinGen gnomAD
rs766292951 CA6563948	514	E>G		No	ClinGen ExAC TOPMed gnomAD
rs1366803023 CA384823798	514	E>K		No	ClinGen gnomAD
rs959809603 CA236809769	516	D>V		No	ClinGen TOPMed
rs988601605 CA236809772	518	E>G		No	ClinGen TOPMed
CA384824514 rs1355402962	519	E>A		No	ClinGen TOPMed
rs200518612 CA6563959	522	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1238449141 CA384824542	523	S>I		No	ClinGen TOPMed
CA384824571 rs1316629085	527	P>L		No	ClinGen TOPMed
CA384824572 rs1314103291	528	A>S		No	ClinGen TOPMed
CA236809801 rs751795234	530	E>K		No	ClinGen gnomAD
TCGA novel	532	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747655030 CA6563962	535	T>I		No	ClinGen ExAC gnomAD
rs912990449 CA236809820	536	S>C		No	ClinGen TOPMed gnomAD
rs968507524 CA236809825	537	A>T		No	ClinGen TOPMed
rs1412750012 CA384824641	538	Q>P		No	ClinGen gnomAD
rs771488452 CA6563963	539	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1172660344 CA384824655	540	L>F		No	ClinGen gnomAD
CA384824658 rs1398007450	540	L>R		No	ClinGen gnomAD
CA236809832 rs1063078	541	N>S		No	ClinGen TOPMed gnomAD
CA6563964 rs78511636	542	M>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1361014635 CA384824679	543	S>N		No	ClinGen gnomAD
CA6563965 rs746932732	544	T>A		No	ClinGen ExAC gnomAD
rs370779483 CA6563966	544	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	545	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs374440389 CA6563967	545	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA6563968 rs759458238	547	P>L		No	ClinGen ExAC gnomAD
rs764358562 CA6563969	552	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1139998 CA236809871	552	L>P		No	ClinGen Ensembl
CA384824742 rs1224708842	554	A>T		No	ClinGen gnomAD
CA384824789 rs1565769829	559	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1157107432 CA384824807	561	E>G		No	ClinGen gnomAD
rs1196223143 CA384824819	563	D>N		No	ClinGen TOPMed
rs753170552 CA6563997	565	I>L		No	ClinGen ExAC TOPMed gnomAD
rs757953216 CA6563998	565	I>M		No	ClinGen ExAC gnomAD
rs1565770002 CA384824851	567	D>E		No	ClinGen Ensembl
CA384824857 rs1326014496	568	S>C		No	ClinGen gnomAD
CA384824861 rs1436438270	569	S>A		No	ClinGen gnomAD
rs376154925 CA6563999	569	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	569	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751060354 CA6564000	571	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1370237938 CA384824890	573	D>V		No	ClinGen TOPMed
rs1440898713 CA384824909	576	N>S		No	ClinGen TOPMed
CA6564001 rs756863416	578	T>A		No	ClinGen ExAC gnomAD
rs1283448206 CA384824930	579	T>I		No	ClinGen gnomAD
CA6564004 rs769831090	583	S>F		No	ClinGen ExAC TOPMed gnomAD
rs1449764438 CA384824961	584	P>L		No	ClinGen gnomAD
rs1198138710 CA384824969	586	S>G		No	ClinGen TOPMed gnomAD
CA6564005 rs779711403	587	T>I		No	ClinGen ExAC gnomAD
CA6564006 rs376999643	588	T>S		No	ClinGen ExAC gnomAD
CA236810170 rs374130369	589	K>Q		No	ClinGen ESP TOPMed gnomAD
CA384825001 rs1425607216	591	S>A		No	ClinGen gnomAD
COSM3416916 rs370890092 CA236810176	591	S>L	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA384825013 rs1405235197	593	A>S		No	ClinGen gnomAD
TCGA novel	594	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6564008 rs773444730	595	T>S		No	ClinGen ExAC gnomAD
TCGA novel	596	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6564009 rs760680436	597	S>T		No	ClinGen ExAC
rs200379125 CA6564010	599	C>Y		No	ClinGen ESP TOPMed gnomAD
rs1400304178 CA384825060	600	N>K		No	ClinGen gnomAD
CA6564012 rs771011602	601	N>Y		No	ClinGen ExAC gnomAD
rs1306532071 CA384825071	602	N>Y		No	ClinGen gnomAD
rs776748586 CA6564013	603	I>T		No	ClinGen ExAC gnomAD
CA384825087 rs1245117504	604	N>S		No	ClinGen gnomAD
rs759954171 CA6564014	605	A>V		No	ClinGen ExAC gnomAD
CA6564015 rs202224219	607	T>P		No	ClinGen ExAC TOPMed gnomAD
CA6564016 rs752978169	609	V>A		No	ClinGen ExAC TOPMed gnomAD
CA236810193 rs1028742675	609	V>M		No	ClinGen TOPMed
CA6564017 rs763394191	610	A>P		No	ClinGen ExAC TOPMed gnomAD
CA384825119 rs1361843724	610	A>V		No	ClinGen gnomAD
rs1459080848 CA384825123	611	L>V		No	ClinGen gnomAD
CA384825128 rs1398482706	612	Q>*		No	ClinGen gnomAD
rs986718590 CA236810840	615	R>Q		No	ClinGen TOPMed
CA6564059 rs757446558	624	Q>R		No	ClinGen ExAC gnomAD
rs1398024321 CA384825509	626	P>L		No	ClinGen gnomAD
CA384825517 rs1312787565	628	K>E		No	ClinGen gnomAD
COSM1606234 CA384825536 rs1593515867	630	P>L	liver [Cosmic]	No	ClinGen cosmic curated Ensembl
CA236810874 rs1017834437	632	S>L		No	ClinGen TOPMed
CA384825545 rs1254410635	632	S>P		No	ClinGen gnomAD
CA6564063 rs372751783	633	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs769917313 CA6564062	633	V>F		No	ClinGen ExAC
rs1217690574 CA384825557	634	L>P		No	ClinGen gnomAD
CA6564064 rs749791498	635	V>G		No	ClinGen ExAC TOPMed gnomAD
rs1290842781 CA384825561	635	V>L		No	ClinGen gnomAD
rs377181777 CA6564067	639	R>Q		No	ClinGen ESP ExAC gnomAD
rs774826971 CA6564066	639	R>W		No	ClinGen ExAC gnomAD
CA6564068 rs767231125	640	E>K		No	ClinGen ExAC gnomAD
rs1200332176 CA384825596	641	L>P		No	ClinGen gnomAD
CA236810895 rs556835847	641	L>V		No	ClinGen Ensembl
rs370588459 CA6564069	642	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA6564071 rs765899403	644	N>K		No	ClinGen ExAC gnomAD
CA6564070 rs760045934	644	N>S		No	ClinGen ExAC gnomAD
CA6564072 rs753354204	645	V>M		No	ClinGen ExAC gnomAD
rs765205260 CA6564075	647	S>A		No	ClinGen ExAC TOPMed gnomAD
CA6564074 rs765205260	647	S>P		No	ClinGen ExAC TOPMed gnomAD
CA6564076 rs758217567	649	T>N		No	ClinGen ExAC
CA6564077 rs781320632	652	E>K		No	ClinGen ExAC gnomAD
rs746119768 CA6564078	653	D>N		No	ClinGen ExAC gnomAD
rs1299256124 CA384825672	654	N>D		No	ClinGen gnomAD
rs756353381 CA6564079	654	N>S		No	ClinGen ExAC gnomAD
CA384825683 rs1241101259	655	G>E		No	ClinGen TOPMed gnomAD
rs780181827 CA6564080	656	A>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	657	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA384825700 rs749369876	658	E>K		No	ClinGen ExAC TOPMed gnomAD
CA6564081 rs749369876	658	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs200404338 CA236810944	658	E>V		No	ClinGen Ensembl
CA6564083 rs775022827	661	V>A		No	ClinGen ExAC gnomAD
CA384825742 rs374242008	661	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
COSM3667169 CA6564082 rs374242008	661	V>I	liver [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1190000870 CA384825772	663	K>N		No	ClinGen TOPMed gnomAD
rs748484357 CA6564084	663	K>R		No	ClinGen ExAC TOPMed gnomAD
rs748484357 CA384825769	663	K>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	664	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6564085 rs772569395	664	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1178803154 CA384825793	665	H>R		No	ClinGen gnomAD
TCGA novel	666	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1381764513 CA384825833	668	P>T		No	ClinGen TOPMed gnomAD
CA384825867 rs1287381421	670	A>G		No	ClinGen TOPMed
CA236810957 rs573470956	670	A>T		No	ClinGen Ensembl
CA6564086 rs773506924	671	R>K		No	ClinGen ExAC TOPMed gnomAD
rs1158066961 CA384825893	672	A>G		No	ClinGen gnomAD
CA384825884 rs1356577933	672	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs760370223 CA6564087	673	S>G		No	ClinGen ExAC gnomAD
rs1459334779 CA384825905	673	S>T		No	ClinGen gnomAD
TCGA novel	677	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs928975486 CA236810964	680	R>*		No	ClinGen TOPMed
rs553516648 CA6564088	680	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA6564089 rs776182357	682	N>S		No	ClinGen ExAC gnomAD
rs776182357 CA384826026	682	N>T		No	ClinGen ExAC gnomAD
rs908966750 CA236810975	683	I>V		No	ClinGen TOPMed gnomAD
rs752631432 CA6564092	688	A>P		No	ClinGen ExAC TOPMed gnomAD
rs752631432 CA6564093	688	A>S		No	ClinGen ExAC TOPMed gnomAD
CA6564094 rs763939123	689	A>V		No	ClinGen ExAC TOPMed gnomAD
CA6564095 rs201243004	691	K>I		No	ClinGen ExAC TOPMed gnomAD
rs201243004 CA236810979	691	K>T		No	ClinGen ExAC TOPMed gnomAD
rs1265382552 CA384826083	692	I>L		No	ClinGen gnomAD
CA384826089 rs1181821962	692	I>M		No	ClinGen TOPMed
rs1458649255 CA384826107	695	Q>*		No	ClinGen gnomAD
CA6564096 rs756332538	697	R>C		No	ClinGen ExAC TOPMed gnomAD
CA384826122 rs1259798490	697	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1185532330 CA384826128	698	Q>P		No	ClinGen TOPMed
rs201453176 CA6564098	699	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6564099 rs753922775	700	S>N		No	ClinGen ExAC gnomAD
CA6564100 rs755140929	701	H>R		No	ClinGen ExAC TOPMed gnomAD
CA384826149 rs1414201049	701	H>Y		No	ClinGen gnomAD
rs779497198 COSM3772645 CA6564101	703	A>G	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA384826162 rs1162533430	703	A>P		No	ClinGen gnomAD
CA6564102 rs779497198	703	A>V		No	ClinGen ExAC TOPMed gnomAD
CA6564103 rs772773414	704	I>V		No	ClinGen ExAC TOPMed gnomAD
CA6564104 rs778167144	705	P>R		No	ClinGen ExAC gnomAD
CA236811025 rs56037675	706	Q>R		No	ClinGen Ensembl
CA6564105 rs747380198	707	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1447985139 CA384826188	708	V>M		No	ClinGen gnomAD
CA6564108 COSM3416917 rs776176069	710	R>*	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs776176069 CA384826200	710	R>G		No	ClinGen ExAC gnomAD
rs769304230 CA384826202	710	R>L		No	ClinGen ExAC TOPMed gnomAD
rs769304230 CA6564109	710	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA6564110 rs367566217	711	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs576259847 CA6564112	711	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs576259847 CA6564111	711	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1593519326 CA384826206	712	N>H		No	ClinGen Ensembl
rs371799393 CA384826218	713	G>D		No	ClinGen ESP TOPMed gnomAD
CA384826214 rs1319175110	713	G>S		No	ClinGen gnomAD
rs371799393 CA236811067	713	G>V		No	ClinGen ESP TOPMed gnomAD
rs1033070930 CA236811071	714	K>E		No	ClinGen TOPMed
CA6564113 rs199611225	715	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1420329667 CA384826263	720	P>S		No	ClinGen TOPMed
CA384826272 rs1484064833	721	R>S		No	ClinGen TOPMed gnomAD
CA384826275 rs1179899912	722	S>P		No	ClinGen gnomAD
rs755051248 CA6564117	725	K>K		No	ClinGen ExAC gnomAD

No associated diseases with Q71RC2

2 regional properties for Q71RC2

Type	Name	Position	InterPro Accession
domain	La-type HTH domain	113 - 202	IPR006630
domain	LARP4, RNA recognition motif	199 - 275	IPR034903

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm, Stress granule Cytoplasm, cytosol	Localized throughout the cytosol Partially localized in stress granules in response to arsenite treatment
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytoplasmic stress granule	A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

3 GO annotations of molecular function

Name	Definition
mRNA 3'-UTR binding	Binding to a 3' untranslated region of an mRNA molecule.
poly(A) binding	Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.
RNA binding	Binding to an RNA molecule or a portion thereof.

5 GO annotations of biological process

Name	Definition
cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
positive regulation of translation	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
post-transcriptional regulation of gene expression	Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
regulation of cell morphogenesis	Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized.
translation	The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

5 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q4G0J3	LARP7	La-related protein 7	Homo sapiens (Human)	PR
P05455	SSB	Lupus La protein	Homo sapiens (Human)	PR
Q6PKG0	LARP1	La-related protein 1	Homo sapiens (Human)	PR
Q659C4	LARP1B	La-related protein 1B	Homo sapiens (Human)	PR
Q6ZQ58	Larp1	La-related protein 1	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MLLFVEQVAS	KGTGLNPNAK	VWQEIAPGNT	DATPVTHGTE	SSWHEIAATS	GAHPEGNAEL
70	80	90	100	110	120
SEDICKEYEV	MYSSSCETTR	NTTGIEESTD	GMILGPEDLS	YQIYDVSGES	NSAVSTEDLK
130	140	150	160	170	180
ECLKKQLEFC	FSRENLSKDL	YLISQMDSDQ	FIPIWTVANM	EEIKKLTTDP	DLILEVLRSS
190	200	210	220	230	240
PMVQVDEKGE	KVRPSHKRCI	VILREIPETT	PIEEVKGLFK	SENCPKVISC	EFAHNSNWYI
250	260	270	280	290	300
TFQSDTDAQQ	AFKYLREEVK	TFQGKPIMAR	IKAINTFFAK	NGYRLMDSSI	YSHPIQTQAQ
310	320	330	340	350	360
YASPVFMQPV	YNPHQQYSVY	SIVPQSWSPN	PTPYFETPLA	PFPNGSFVNG	FNSPGSYKTN
370	380	390	400	410	420
AAAMNMGRPF	QKNRVKPQFR	SSGGSEHSTE	GSVSLGDGQL	NRYSSRNFPA	ERHNPTVTGH
430	440	450	460	470	480
QEQTYLQKET	STLQVEQNGD	YGRGRRTLFR	GRRRREDDRI	SRPHPSTAES	KAPTPKFDLL
490	500	510	520	530	540
ASNFPPLPGS	SSRMPGELVL	ENRMSDVVKG	VYKEKDNEEL	TISCPVPADE	QTECTSAQQL
550	560	570	580	590	600
NMSTSSPCAA	ELTALSTTQQ	EKDLIEDSSV	QKDGLNQTTI	PVSPPSTTKP	SRASTASPCN
610	620	630	640	650	660
NNINAATAVA	LQEPRKLSYA	EVCQKPPKEP	SSVLVQPLRE	LRSNVVSPTK	NEDNGAPENS
670	680	690	700	710	720
VEKPHEKPEA	RASKDYSGFR	GNIIPRGAAG	KIREQRRQFS	HRAIPQGVTR	RNGKEQYVPP

RSPK