P49891

PR
Gene name
Sult1e1 (Est)
Protein name
Sulfotransferase 1E1
Names
ST1E1, Estrogen sulfotransferase, testis isoform, Sulfotransferase, estrogen-preferring
Species
Mus musculus (Mouse)
KEGG Pathway
EC number
2.8.2.4: Sulfotransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

69-138 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for P49891

Entry ID Method Resolution Chain Position Source
1AQU X-ray 160 A A/B 1-295 PDB
1AQY X-ray 175 A A/B 1-295 PDB
1BO6 X-ray 210 A A/B 1-295 PDB
AF-P49891-F1 Predicted AlphaFoldDB

No variants for P49891

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P49891

No associated diseases with P49891

1 regional properties for P49891

Type Name Position InterPro Accession
domain Sulfotransferase domain 38 - 287 IPR000863

Functions

Description
EC Number 2.8.2.4 Sulfotransferases
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.

6 GO annotations of molecular function

Name Definition
aryl sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.
estrone sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate.
flavonol 3-sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H(+) + quercetin 3-sulfate.
steroid binding Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.
steroid sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate.
sulfotransferase activity Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.

7 GO annotations of biological process

Name Definition
3'-phosphoadenosine 5'-phosphosulfate metabolic process The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems.
estrogen catabolic process The chemical reactions and pathways resulting in the breakdown of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
estrogen metabolic process The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
ethanol catabolic process The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation.
female pregnancy The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
positive regulation of fat cell differentiation Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.
sulfation The addition of a sulfate group to a molecule.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P19217 SULT1E1 Sulfotransferase 1E1 Bos taurus (Bovine) PR
Q06520 SULT2A1 Sulfotransferase 2A1 Homo sapiens (Human) PR
Q9BR01 SULT4A1 Sulfotransferase 4A1 Homo sapiens (Human) PR
P49888 SULT1E1 Sulfotransferase 1E1 Homo sapiens (Human) PR
O35403 Sult3a1 Amine sulfotransferase Mus musculus (Mouse) PR
P0CC03 Sult6b1 Sulfotransferase 6B1 Mus musculus (Mouse) PR
Q3UZZ6 Sult1d1 Sulfotransferase 1 family member D1 Mus musculus (Mouse) PR
P17988 Sult1a1 Sulfotransferase 1A1 Rattus norvegicus (Rat) PR
P49890 Ste2 Estrogen sulfotransferase Ste2 Rattus norvegicus (Rat) PR
P49889 Ste Estrogen sulfotransferase, isoform 3 Rattus norvegicus (Rat) PR
Q9FX55 STO9 Cytosolic sulfotransferase 9 Arabidopsis thaliana (Mouse-ear cress) PR
Q9STQ6 SOT3 Cytosolic sulfotransferase 3 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
METSMPEYYE VFGEFRGVLM DKRFTKYWED VEMFLARPDD LVIATYPKSG TTWISEVVYM
70 80 90 100 110 120
IYKEGDVEKC KEDAIFNRIP YLECRNEDLI NGIKQLKEKE SPRIVKTHLP PKLLPASFWE
130 140 150 160 170 180
KNCKMIYLCR NAKDVAVSYY YFLLMITSYP NPKSFSEFVE KFMQGQVPYG SWYDHVKAWW
190 200 210 220 230 240
EKSKNSRVLF MFYEDMKEDI RREVVKLIEF LERKPSAELV DRIIQHTSFQ EMKNNPSTNY
250 260 270 280 290
TMMPEEMMNQ KVSPFMRKGI IGDWKNHFPE ALRERFDEHY KQQMKDCTVK FRMEL