P17988

PR
Gene name
Sult1a1 (St1a1)
Protein name
Sulfotransferase 1A1
Names
ST1A1, Aryl sulfotransferase, Aryl sulfotransferase IV, ASTIV, Minoxidil sulfotransferase, Mx-ST, PST-1, Phenol sulfotransferase, Sulfokinase, Tyrosine-ester sulfotransferase
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:83783
EC number
2.8.2.1: Sulfotransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

203-276 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P17988

Entry ID Method Resolution Chain Position Source
AF-P17988-F1 Predicted AlphaFoldDB

No variants for P17988

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P17988

No associated diseases with P17988

1 regional properties for P17988

Type Name Position InterPro Accession
domain Sulfotransferase domain 34 - 283 IPR000863

Functions

Description
EC Number 2.8.2.1 Sulfotransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

7 GO annotations of molecular function

Name Definition
3'-phosphoadenosine 5'-phosphosulfate binding Binding to 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems.
aryl sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.
flavonol 3-sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H(+) + quercetin 3-sulfate.
identical protein binding Binding to an identical protein or proteins.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
steroid sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate.
sulfotransferase activity Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.

13 GO annotations of biological process

Name Definition
3'-phosphoadenosine 5'-phosphosulfate metabolic process The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems.
4-nitrophenol metabolic process The chemical reactions and pathways involving 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion.
catecholamine metabolic process The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.
estrogen metabolic process The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
ethanol catabolic process The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation.
flavonoid metabolic process The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins.
regulation of blood pressure Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
response to activity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
response to glucocorticoid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
response to insecticide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects.
sulfation The addition of a sulfate group to a molecule.
thyroid hormone metabolic process The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.
xenobiotic metabolic process The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P19217 SULT1E1 Sulfotransferase 1E1 Bos taurus (Bovine) PR
Q06520 SULT2A1 Sulfotransferase 2A1 Homo sapiens (Human) PR
P49888 SULT1E1 Sulfotransferase 1E1 Homo sapiens (Human) PR
Q9BR01 SULT4A1 Sulfotransferase 4A1 Homo sapiens (Human) PR
P49891 Sult1e1 Sulfotransferase 1E1 Mus musculus (Mouse) PR
O35403 Sult3a1 Amine sulfotransferase Mus musculus (Mouse) PR
Q3UZZ6 Sult1d1 Sulfotransferase 1 family member D1 Mus musculus (Mouse) PR
P0CC03 Sult6b1 Sulfotransferase 6B1 Mus musculus (Mouse) PR
P49890 Ste2 Estrogen sulfotransferase Ste2 Rattus norvegicus (Rat) PR
P49889 Ste Estrogen sulfotransferase, isoform 3 Rattus norvegicus (Rat) PR
Q9FX55 STO9 Cytosolic sulfotransferase 9 Arabidopsis thaliana (Mouse-ear cress) PR
Q9STQ6 SOT3 Cytosolic sulfotransferase 3 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEFSRPPLVH VKGIPLIKYF AETIGPLQNF TAWPDDLLIS TYPKSGTTWM SEILDMIYQG
70 80 90 100 110 120
GKLEKCGRAP IYARVPFLEF KCPGVPSGLE TLEETPAPRL LKTHLPLSLL PQSLLDQKVK
130 140 150 160 170 180
VIYIARNAKD VVVSYYNFYN MAKLHPDPGT WDSFLENFMD GEVSYGSWYQ HVKEWWELRH
190 200 210 220 230 240
THPVLYLFYE DIKENPKREI KKILEFLGRS LPEETVDSIV HHTSFKKMKE NCMTNYTTIP
250 260 270 280 290
TEIMDHNVSP FMRKGTTGDW KNTFTVAQNE RFDAHYAKTM TDCDFKFRCE L