P0CC03

PR
Gene name
Sult6b1
Protein name
Sulfotransferase 6B1
Names
ST6B1, Thyroxine sulfotransferase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:73671
EC number
2.8.2.n2: Sulfotransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

207-286 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0CC03

Entry ID Method Resolution Chain Position Source
AF-P0CC03-F1 Predicted AlphaFoldDB

30 variants for P0CC03

Variant ID(s) Position Change Description Diseaes Association Provenance
rs236419241 50 A>D No EVA
rs216769277 55 S>C No EVA
rs3408006067 66 C>F No EVA
rs3406181790 66 C>R No EVA
rs1132386285 84 K>E No EVA
rs1135078621 85 K>Q No EVA
rs1132647594 87 Y>D No EVA
rs51444952 88 A>T No EVA
rs3389481847 104 Q>L No EVA
rs257446071 110 P>S No EVA
rs3389460173 115 L>Q No EVA
rs3389493266 126 Q>* No EVA
rs264259782 133 A>V No EVA
rs3389472317 158 D>H No EVA
rs3389392362 159 I>F No EVA
rs3389475492 184 D>E No EVA
rs3389496260 216 Q>* No EVA
rs3389481801 224 S>F No EVA
rs3389481801 224 S>Y No EVA
rs3389481859 225 L>* No EVA
rs46691280 235 T>A No EVA
rs3389493322 235 T>I No EVA
rs3389475472 250 H>Q No EVA
rs49821777 254 G>R No EVA
rs3389472292 264 G>R No EVA
rs3389477307 270 F>S No EVA
rs3389475428 287 A>V No EVA
rs3407669513 294 K>* No EVA
rs3407388349 296 K>N No EVA
rs3389460161 302 L>Q No EVA

No associated diseases with P0CC03

1 regional properties for P0CC03

Type Name Position InterPro Accession
domain Sulfotransferase domain 56 - 289 IPR000863

Functions

Description
EC Number 2.8.2.n2 Sulfotransferases
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

1 GO annotations of molecular function

Name Definition
sulfotransferase activity Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.

1 GO annotations of biological process

Name Definition
sulfation The addition of a sulfate group to a molecule.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P19217 SULT1E1 Sulfotransferase 1E1 Bos taurus (Bovine) PR
Q06520 SULT2A1 Sulfotransferase 2A1 Homo sapiens (Human) PR
P49888 SULT1E1 Sulfotransferase 1E1 Homo sapiens (Human) PR
Q9BR01 SULT4A1 Sulfotransferase 4A1 Homo sapiens (Human) PR
Q3UZZ6 Sult1d1 Sulfotransferase 1 family member D1 Mus musculus (Mouse) PR
O35403 Sult3a1 Amine sulfotransferase Mus musculus (Mouse) PR
P49891 Sult1e1 Sulfotransferase 1E1 Mus musculus (Mouse) PR
P49890 Ste2 Estrogen sulfotransferase Ste2 Rattus norvegicus (Rat) PR
P17988 Sult1a1 Sulfotransferase 1A1 Rattus norvegicus (Rat) PR
Q9FX55 STO9 Cytosolic sulfotransferase 9 Arabidopsis thaliana (Mouse-ear cress) PR
Q9STQ6 SOT3 Cytosolic sulfotransferase 3 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MADKSKFIDY IDDALEKSKE TTLSQLFLTY QGIPYPVTMC TQETFRALDA FEARSDDVLL
70 80 90 100 110 120
ASYPKCGSNW ILHIVSELIF AVSKKKYACP EFPVLECGDA EKYQRMKLFP SPRILTTHLH
130 140 150 160 170 180
YDKLPQSIFK NKAKILVIFR NPKDTAVSFF HFHNDVPDIP SYASWDEFFR QFIKGQVSWG
190 200 210 220 230 240
SYFDFAINWN KHIDDENVKF ILYEDLKENL VVGIKQISEF LGFSLTDEQI ETISTQSTFL
250 260 270 280 290 300
AMRANSQETH GAIGPFLFRK GEVGDWKRLF NETQNQEMDE RFKECLAGTS LGDKLKYEAY
CLA