Q3UZZ6

PR
Gene name
Sult1d1 (St1d1)
Protein name
Sulfotransferase 1 family member D1
Names
ST1D1, Amine N-sulfotransferase, SULT-N, Dopamine sulfotransferase Sult1d1, Tyrosine-ester sulfotransferase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:53315
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

208-287 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

8 structures for Q3UZZ6

Entry ID Method Resolution Chain Position Source
2ZPT X-ray 115 A X 1-295 PDB
2ZVP X-ray 130 A X 1-295 PDB
2ZVQ X-ray 130 A X 1-295 PDB
2ZYT X-ray 155 A X 1-295 PDB
2ZYU X-ray 180 A X 1-295 PDB
2ZYV X-ray 181 A X 1-295 PDB
2ZYW X-ray 180 A X 1-295 PDB
AF-Q3UZZ6-F1 Predicted AlphaFoldDB

3 variants for Q3UZZ6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388761954 177 K>N No EVA
rs3388762866 180 W>G No EVA
rs254722008 243 M>I No EVA

No associated diseases with Q3UZZ6

1 regional properties for Q3UZZ6

Type Name Position InterPro Accession
domain Sulfotransferase domain 38 - 287 IPR000863

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
aryl sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.
sulfotransferase activity Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.

4 GO annotations of biological process

Name Definition
catecholamine metabolic process The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.
lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
sulfate assimilation The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds.
sulfation The addition of a sulfate group to a molecule.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P19217 SULT1E1 Sulfotransferase 1E1 Bos taurus (Bovine) PR
Q06520 SULT2A1 Sulfotransferase 2A1 Homo sapiens (Human) PR
P49888 SULT1E1 Sulfotransferase 1E1 Homo sapiens (Human) PR
Q9BR01 SULT4A1 Sulfotransferase 4A1 Homo sapiens (Human) PR
P0CC03 Sult6b1 Sulfotransferase 6B1 Mus musculus (Mouse) PR
O35403 Sult3a1 Amine sulfotransferase Mus musculus (Mouse) PR
P49891 Sult1e1 Sulfotransferase 1E1 Mus musculus (Mouse) PR
P49890 Ste2 Estrogen sulfotransferase Ste2 Rattus norvegicus (Rat) PR
P17988 Sult1a1 Sulfotransferase 1A1 Rattus norvegicus (Rat) PR
Q9FX55 STO9 Cytosolic sulfotransferase 9 Arabidopsis thaliana (Mouse-ear cress) PR
Q9STQ6 SOT3 Cytosolic sulfotransferase 3 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MDNKLDVFRR ELVDVEGIPL FWSIAEHWSQ VESFEARPDD ILISTYPKSG TTWVSEILDL
70 80 90 100 110 120
IYNNGDAEKC KRDAIYKRVP FMELIIPGIT NGVEMLNNMP SPRIVKTHLP VQLLPSSFWK
130 140 150 160 170 180
NDCKIIYVAR NAKDVVVSYY YFYQMAKIHP EPGTWEEFLE KFMAGQVSFG PWYDHVKSWW
190 200 210 220 230 240
EKRKEYRILY LFYEDMKENP KCEIQKILKF LEKDIPEEIL NKILYHSSFS VMKENPSANY
250 260 270 280 290
TTMMKEEMDH SVSPFMRKGI SGDWKNQFTV AQYEKFEEDY VKKMEDSTLK FRSEI