AiPD: Autoinhibited Protein Database

P49888

Gene name	SULT1E1 (STE)
Protein name	Sulfotransferase 1E1
Names	ST1E1, EST-1, Estrogen sulfotransferase, Sulfotransferase, estrogen-preferring
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6783
EC number	2.8.2.4: Sulfotransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

196-284 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

196-284 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

6 structures for P49888

Entry ID	Method	Resolution	Chain	Position	Source
1G3M	X-ray	170 A	A/B	1-294	PDB
1HY3	X-ray	180 A	A/B	1-294	PDB
4JVL	X-ray	194 A	A/B	1-294	PDB
4JVM	X-ray	199 A	A/B	1-294	PDB
4JVN	X-ray	205 A	A/B	1-294	PDB
AF-P49888-F1	Predicted				AlphaFoldDB

259 variants for P49888

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	4	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA357121063 rs1253443841	4	E>G		No	ClinGen gnomAD
CA2947907 rs759418370	5	L>P		No	ClinGen ExAC gnomAD
rs1337948815 CA357121050	6	D>A		No	ClinGen TOPMed
TCGA novel	6	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1337948815 CA357121052	6	D>G		No	ClinGen TOPMed
CA357121054 rs776448035	6	D>N		No	ClinGen ExAC TOPMed gnomAD
rs776448035 CA2947906	6	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA2947905 CA357121033 rs770601297	8	Y>*		No	ClinGen ExAC TOPMed gnomAD
CA357121035 rs1212237289	8	Y>C		No	ClinGen Ensembl
CA2947904 rs760568556	9	E>G		No	ClinGen ExAC gnomAD
CA357121018 rs1315010797	10	K>N		No	ClinGen gnomAD
CA357121025 rs1212729292	10	K>Q		No	ClinGen TOPMed
rs1283501045 CA552245759	13	E>V		No	ClinGen gnomAD
CA98902879 rs951769166	14	V>I		No	ClinGen TOPMed
rs1291656655 CA357120984	15	H>R		No	ClinGen gnomAD
rs1578107632 CA357120986	15	H>Y		No	ClinGen Ensembl
CA2947901 rs771777989	16	G>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA98902869 rs756987917	16	G>R		No	ClinGen Ensembl
CA357120973 rs1356472094	17	I>N		No	ClinGen gnomAD
COSM1540959 CA2947900 rs747589749	18	L>I	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA357120962 rs1452112056	19	M>T		No	ClinGen gnomAD
CA2947899 rs778407495	20	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA357120941 rs11569705	22	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
VAR_018907 CA2947898 rs11569705	22	D>Y		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA357120929 rs1400776691	23	F>C		No	ClinGen gnomAD
TCGA novel	23	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA357120924 rs1413605093	24	V>F		No	ClinGen gnomAD
rs995933228 CA98902826	29	N>I		No	ClinGen TOPMed gnomAD
CA98902800 rs965838849	29	N>K		No	ClinGen TOPMed gnomAD
CA2947896 rs780646274	30	V>A		No	ClinGen ExAC gnomAD
CA357120872 rs1462302523	31	E>G		No	ClinGen TOPMed
rs34547148 CA2947895	32	A>V	Variant assessed as Somatic; 4.625e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs781501252 CA2947893	34	Q>K		No	ClinGen ExAC gnomAD
CA2947892 rs150180382	35	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs140959829 CA2947891	36	R>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA357120807 rs1295363573	41	V>F		No	ClinGen gnomAD
rs994190559 CA98902757	42	I>V		No	ClinGen Ensembl
CA98902756 rs370310742	43	A>D		No	ClinGen Ensembl
CA357120795 rs1380820438	43	A>T		No	ClinGen gnomAD
CA357120791 rs1340652336	44	T>A		No	ClinGen TOPMed
CA98902750 rs771011878	46	P>L		No	ClinGen Ensembl
rs1361781887 CA357120771	47	K>*		No	ClinGen gnomAD
CA357120772 rs1361781887	47	K>E		No	ClinGen gnomAD
CA357120762 rs1336407598	48	S>C		No	ClinGen TOPMed
CA98902734 rs1052854963	48	S>P		No	ClinGen TOPMed
CA357120760 rs1210226778	49	G>S		No	ClinGen TOPMed
CA357120648 rs1460190031	49	G>V		No	ClinGen gnomAD
CA2947866 rs761632873	51	T>A		No	ClinGen ExAC TOPMed gnomAD
CA357120624 rs1170826222	51	T>I		No	ClinGen gnomAD
rs1393123762 CA357120603	53	V>F		No	ClinGen TOPMed gnomAD
CA357120601 rs1393123762	53	V>I		No	ClinGen TOPMed gnomAD
rs1169474896 CA357120585	54	S>N		No	ClinGen TOPMed
CA98900940 rs151059452	56	I>T		No	ClinGen ESP TOPMed
CA2947862 rs762363288	59	M>I		No	ClinGen ExAC gnomAD
rs374660092 CA2947863	59	M>R		No	ClinGen ESP ExAC gnomAD
rs1165860521 CA357120495	60	I>T		No	ClinGen TOPMed gnomAD
CA2947861 rs565167986	60	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs770155636 CA2947860	63	E>V		No	ClinGen ExAC gnomAD
CA357120413 rs1385185213	67	E>K		No	ClinGen TOPMed
rs1346169151 CA357120384	68	K>N		No	ClinGen gnomAD
rs898450686 CA98900892	69	C>*		No	ClinGen TOPMed
TCGA novel	69	C>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746411706 CA2947859	72	D>N		No	ClinGen ExAC gnomAD
CA2947858 rs546818174	73	V>A		No	ClinGen 1000Genomes ExAC gnomAD
rs1346200852 CA357120301	74	I>V		No	ClinGen TOPMed
COSM195320 rs143726522 CA2947856	77	R>*	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
COSM1057027 CA2947855 rs561070029	77	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA2947854 rs758649472	79	P>T		No	ClinGen ExAC gnomAD
TCGA novel	82	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1431397129 CA357120118	83	C>F		No	ClinGen gnomAD
CA98900854 rs201713752	84	R>K		No	ClinGen 1000Genomes
rs779072453 CA2947852	86	E>G		No	ClinGen ExAC TOPMed
rs779072453 CA357120075	86	E>V		No	ClinGen ExAC TOPMed
rs1373462403 CA357120060	87	N>T		No	ClinGen gnomAD
CA2947851 rs369931271	88	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA2947849 rs767488336	90	N>S		No	ClinGen ExAC gnomAD
rs1260261039 CA357119954	91	G>E		No	ClinGen gnomAD
COSM345654 CA98900096 CA357119941 rs1039261878	92	V>L	lung [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs781100262 CA2947827	94	Q>H		No	ClinGen ExAC gnomAD
CA357119898 rs1229728603	94	Q>L		No	ClinGen gnomAD
CA357119849 rs1560557484	98	M>R		No	ClinGen Ensembl
CA357119841 rs1448400065	99	N>Y		No	ClinGen TOPMed gnomAD
CA357119823 rs1578106152	101	P>L		No	ClinGen Ensembl
CA357119822 rs1578106137	102	R>G		No	ClinGen Ensembl
CA357119808 rs1342112380	104	V>M		No	ClinGen gnomAD
TCGA novel	106	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	107	H>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA357119784 rs1316115370	107	H>R		No	ClinGen gnomAD
rs1381627195 CA357119774	108	L>F		No	ClinGen gnomAD
rs1389330164 CA357119767	110	P>S		No	ClinGen gnomAD
rs757187819 CA2947826	111	E>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	112	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751266095 CA2947825	112	L>H		No	ClinGen ExAC gnomAD
rs1390191954 CA357119742	114	P>A		No	ClinGen TOPMed
CA357119735 rs1422748137	115	A>T		No	ClinGen TOPMed
rs369730845 CA98900074	116	S>L		No	ClinGen ESP TOPMed
CA357119707 rs1399809857	118	W>*		No	ClinGen TOPMed
rs758171863 CA2947823	119	E>A		No	ClinGen ExAC gnomAD
rs377668366 CA2947821	121	D>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA357119640 rs1250466056	122	C>S		No	ClinGen gnomAD
CA2947818 rs766932921	123	K>E		No	ClinGen ExAC gnomAD
rs369506037 CA2947817	123	K>R		No	ClinGen ESP ExAC gnomAD
rs767962674 CA2947796 COSM3767958	126	Y>C	liver [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs767962674 CA2947797	126	Y>S		No	ClinGen ExAC TOPMed gnomAD
CA357118904 rs1438726969	127	L>V		No	ClinGen TOPMed gnomAD
CA357118896 rs1334143781	128	C>G		No	ClinGen gnomAD
CA2947794 COSM1057025 rs774700339	129	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs762229711 CA2947795	129	R>W	Variant assessed as Somatic; 4.665e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA2947793 rs777085255	130	N>H		No	ClinGen ExAC gnomAD
rs200590298 CA2947792	131	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs775733144 CA357118858	134	V>L		No	ClinGen ExAC gnomAD
CA2947791 rs775733144	134	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
COSM448076 rs769898905 CA2947790	135	A>T	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA2947787 rs75140571	136	V>A		No	ClinGen ExAC TOPMed gnomAD
rs75140571 CA2947786	136	V>G		No	ClinGen ExAC TOPMed gnomAD
CA2947788 rs757405253	136	V>I		No	ClinGen ExAC TOPMed gnomAD
CA357118844 rs1208507410	137	S>P		No	ClinGen gnomAD
rs1347002481 CA357118829	139	Y>F		No	ClinGen gnomAD
rs1215845180 CA357118819	140	Y>F		No	ClinGen gnomAD
rs1220949195 COSM1057024 CA357118810	141	F>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA98896908 rs140624175	144	M>R		No	ClinGen ESP TOPMed gnomAD
CA357118756 rs200443686	145	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200443686 CA2947783	145	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1578104155 CA357118739	146	A>G		No	ClinGen Ensembl
CA357118728 rs1410720963	147	G>A		No	ClinGen gnomAD
rs779900694 CA2947782	148	H>N		No	ClinGen ExAC gnomAD
TCGA novel	148	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201072711 CA2947781	149	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs899287541 CA98896885	149	P>L		No	ClinGen TOPMed
rs201072711 CA98896890	149	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA357118695 rs1414567936	150	N>D		No	ClinGen TOPMed gnomAD
rs980448935 CA98896858	150	N>S		No	ClinGen gnomAD
CA2947780 rs749963767	153	S>C		No	ClinGen ExAC gnomAD
CA98896848 rs749963767	153	S>F		No	ClinGen ExAC gnomAD
rs17852473 CA98896843	154	F>L		No	ClinGen Ensembl
CA357118663 rs1405231725	154	F>S		No	ClinGen gnomAD
CA357118650 rs1167660789	155	P>L		No	ClinGen TOPMed
rs1578104125 CA357118654	155	P>S		No	ClinGen Ensembl
CA98896832 rs202059677	157	F>L		No	ClinGen 1000Genomes
CA2947778 rs200323054	159	E>D		No	ClinGen ExAC TOPMed gnomAD
CA357118576 rs1472692670	160	K>N		No	ClinGen TOPMed gnomAD
CA98896831 rs761297230	161	F>V		No	ClinGen Ensembl
CA2947777 rs751883127	162	M>I		No	ClinGen ExAC gnomAD
rs764414923 CA2947776	163	Q>*		No	ClinGen ExAC gnomAD
rs764414923 CA357118532	163	Q>K		No	ClinGen ExAC gnomAD
TCGA novel	164	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763360917 CA2947775	164	G>V		No	ClinGen ExAC gnomAD
CA357118361 rs1426530600	166	V>A		No	ClinGen TOPMed gnomAD
CA98895653 rs766053586	167	P>L		No	ClinGen Ensembl
TCGA novel	169	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA98895651 rs990652773	171	W>L		No	ClinGen TOPMed
CA2947743 rs745480703	173	K>*		No	ClinGen ExAC gnomAD
rs756748070 CA2947741	174	H>L		No	ClinGen ExAC gnomAD
CA2947742 rs780948555	174	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs187665009 CA98895628	175	V>I		No	ClinGen 1000Genomes gnomAD
CA98895624 rs762141758	177	S>C		No	ClinGen Ensembl
CA357118247 rs1341977417	178	W>*		No	ClinGen TOPMed gnomAD
CA357118249 rs746588635	178	W>*		No	ClinGen ExAC TOPMed gnomAD
rs746588635 CA2947740	178	W>L		No	ClinGen ExAC TOPMed gnomAD
CA357118240 rs1231316037	179	W>L		No	ClinGen gnomAD
CA2947739 rs778190574	179	W>R		No	ClinGen ExAC TOPMed gnomAD
rs761102787 CA357118236	180	E>*		No	ClinGen ExAC TOPMed gnomAD
CA2947737 rs761102787	180	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs761102787 CA2947738	180	E>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel rs1298507007 CA357118224	181	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen gnomAD NCI-TCGA
CA2947736 rs779178976	182	G>V		No	ClinGen ExAC gnomAD
rs375695702 CA98895603	183	K>N		No	ClinGen ESP
TCGA novel	184	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs753982089 CA2947734	186	R>C	Variant assessed as Somatic; 4.64e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA2947735 rs753982089	186	R>G		No	ClinGen ExAC gnomAD
CA2947733 rs143807523	186	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs143807523 CA98895582	186	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA357118191 rs750534499	187	V>E		No	ClinGen ExAC TOPMed gnomAD
CA2947731 rs750534499	187	V>G		No	ClinGen ExAC TOPMed gnomAD
CA357118176 rs1431509890	190	L>I		No	ClinGen gnomAD
rs1198182168 CA357118165	191	F>L		No	ClinGen TOPMed gnomAD
CA2947730 rs370876189	191	F>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA2947729 rs763005303	192	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1433851522 CA357118162	192	Y>H		No	ClinGen gnomAD
rs769456468 COSM1671053 CA2947727	193	E>K	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1578102027 CA357117642	199	I>F		No	ClinGen Ensembl
CA98892873 COSM734866 rs961222753	202	E>K	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA2947706 rs770525356	204	I>K		No	ClinGen ExAC gnomAD
CA2947707 rs770525356	204	I>T		No	ClinGen ExAC gnomAD
CA357117567 rs1333400088	204	I>V		No	ClinGen TOPMed gnomAD
CA357117516 rs760355185	207	I>L		No	ClinGen ExAC TOPMed gnomAD
rs760355185 CA2947705	207	I>V		No	ClinGen ExAC TOPMed gnomAD
CA357117467 rs1560554129	210	L>Q		No	ClinGen Ensembl
rs1318565962 CA357117459	211	E>G		No	ClinGen gnomAD
CA357117448 rs1185755140	213	K>E		No	ClinGen gnomAD
CA2947704 rs772895034	213	K>R		No	ClinGen ExAC gnomAD
rs373853968 CA2947702	214	P>T		No	ClinGen ESP ExAC gnomAD
rs779280969 CA2947701 COSM1186580	218	L>I	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA98892816 rs779280969	218	L>V		No	ClinGen ExAC TOPMed gnomAD
rs201005072 CA2947700	220	D>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	221	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	223	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA357117304 rs1444588366	224	H>R		No	ClinGen TOPMed gnomAD
rs140157798 CA2947698	225	H>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2947697 rs756363002	226	T>I		No	ClinGen ExAC gnomAD
rs756363002 CA357117274	226	T>S		No	ClinGen ExAC gnomAD
CA2947696 rs201902818	227	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1353949306 CA357117232	229	Q>*		No	ClinGen gnomAD
rs757281208 CA2947694	229	Q>R		No	ClinGen ExAC gnomAD
rs1560554082 CA357117191	233	N>D		No	ClinGen Ensembl
rs754969833 CA2947691	235	P>Q		No	ClinGen ExAC gnomAD
CA357117173 rs754969833	235	P>R		No	ClinGen ExAC gnomAD
rs1181745949 CA357117142	240	T>A		No	ClinGen TOPMed
rs1028422269 CA98892750	240	T>R		No	ClinGen Ensembl
CA357117137 rs1403778910	241	T>A		No	ClinGen gnomAD
rs1027244955 CA98892748	243	P>T		No	ClinGen TOPMed gnomAD
rs546191623 CA2947689	244	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA357117112 rs1578101927	245	E>G		No	ClinGen Ensembl
CA2947687 rs772834116 COSM448075	245	E>K	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1413235220 CA357117107	246	I>L		No	ClinGen TOPMed
rs1188553969 CA357117094	247	M>I		No	ClinGen gnomAD
CA2947686 rs767220507	249	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA2947685 rs761157490	252	S>L	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA98892694 COSM1671052 rs11569712	253	P>H	kidney [Cosmic]	No	ClinGen cosmic curated Ensembl
CA357117055 rs1230054260	253	P>S		No	ClinGen TOPMed
rs746067466 CA98892689	254	F>C		No	ClinGen Ensembl
rs1279885651 CA357117040	255	M>I		No	ClinGen TOPMed
CA2947683 rs768994692	255	M>T		No	ClinGen ExAC gnomAD
COSM1430720 rs1271614778 CA357117043	255	M>V	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA2947682 rs749832097	257	K>R		No	ClinGen ExAC gnomAD
TCGA novel	257	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2947659 rs375271880	260	T>A		No	ClinGen ExAC TOPMed gnomAD
CA2947658 rs372760545	260	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs748291221 CA2947656	261	G>E		No	ClinGen ExAC gnomAD
CA2947657 rs772175816	261	G>R		No	ClinGen ExAC gnomAD
TCGA novel	262	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1172688138 CA357116976	263	W>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA357116953 rs1481185629	266	H>R		No	ClinGen gnomAD
CA2947653 rs756055656	267	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1409331095 COSM1179875 CA357116945	267	F>S	prostate [Cosmic]	No	ClinGen cosmic curated gnomAD
CA98890682 rs1029957861	270	A>S		No	ClinGen Ensembl
rs200630976 CA98890680	270	A>V		No	ClinGen gnomAD
rs1208001735 CA357116926	271	L>M		No	ClinGen gnomAD
rs998851317 CA98890668	274	K>E		No	ClinGen TOPMed
rs1489081047 CA357116900	274	K>N		No	ClinGen TOPMed
CA2947651 rs181450741	274	K>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA357116871 rs1193885357	278	H>R		No	ClinGen TOPMed
rs1221033541 CA357116864	279	Y>C		No	ClinGen gnomAD
CA2947650 rs757040136	279	Y>H		No	ClinGen ExAC gnomAD
CA98890651 rs375864132	280	E>K		No	ClinGen ESP gnomAD
CA357116851 rs1229388897	281	Q>*		No	ClinGen gnomAD
rs1352776526 CA357116833	283	M>T		No	ClinGen gnomAD
CA98890646 rs1020568528	287	T>I		No	ClinGen TOPMed gnomAD
rs763722636 CA2947648	289	K>*		No	ClinGen ExAC gnomAD
CA357116793 rs1457203016	289	K>R		No	ClinGen gnomAD
CA357116794 rs1457203016	289	K>T		No	ClinGen gnomAD
CA98890644 rs865944040	290	F>L		No	ClinGen Ensembl
rs202067669 CA98890643	291	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
COSM1057019 CA2947646 rs748563147	291	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA357116775 rs1453193404	292	T>S		No	ClinGen TOPMed
rs765790939 CA2947645	293	E>D		No	ClinGen ExAC
CA98890635 rs1007085224	294	I>F		No	ClinGen Ensembl
TCGA novel	295	I>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with P49888

1 regional properties for P49888

Type	Name	Position	InterPro Accession
domain	Sulfotransferase domain	37 - 286	IPR000863

Functions

		Description
EC Number	2.8.2.4	Sulfotransferases
Subcellular Localization	Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear membrane	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.

6 GO annotations of molecular function

Name	Definition
aryl sulfotransferase activity	Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.
estrone sulfotransferase activity	Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate.
flavonol 3-sulfotransferase activity	Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H(+) + quercetin 3-sulfate.
steroid binding	Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.
steroid sulfotransferase activity	Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate.
sulfotransferase activity	Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.

7 GO annotations of biological process

Name	Definition
3'-phosphoadenosine 5'-phosphosulfate metabolic process	The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems.
estrogen catabolic process	The chemical reactions and pathways resulting in the breakdown of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
estrogen metabolic process	The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
ethanol catabolic process	The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation.
positive regulation of fat cell differentiation	Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.
steroid metabolic process	The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
sulfation	The addition of a sulfate group to a molecule.

12 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P19217	SULT1E1	Sulfotransferase 1E1	Bos taurus (Bovine)	PR
Q06520	SULT2A1	Sulfotransferase 2A1	Homo sapiens (Human)	PR
Q9BR01	SULT4A1	Sulfotransferase 4A1	Homo sapiens (Human)	PR
O35403	Sult3a1	Amine sulfotransferase	Mus musculus (Mouse)	PR
Q3UZZ6	Sult1d1	Sulfotransferase 1 family member D1	Mus musculus (Mouse)	PR
P0CC03	Sult6b1	Sulfotransferase 6B1	Mus musculus (Mouse)	PR
P49891	Sult1e1	Sulfotransferase 1E1	Mus musculus (Mouse)	PR
P17988	Sult1a1	Sulfotransferase 1A1	Rattus norvegicus (Rat)	PR
P49890	Ste2	Estrogen sulfotransferase Ste2	Rattus norvegicus (Rat)	PR
P49889	Ste	Estrogen sulfotransferase, isoform 3	Rattus norvegicus (Rat)	PR
Q9FX55	STO9	Cytosolic sulfotransferase 9	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9STQ6	SOT3	Cytosolic sulfotransferase 3	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MNSELDYYEK	FEEVHGILMY	KDFVKYWDNV	EAFQARPDDL	VIATYPKSGT	TWVSEIVYMI
70	80	90	100	110	120
YKEGDVEKCK	EDVIFNRIPF	LECRKENLMN	GVKQLDEMNS	PRIVKTHLPP	ELLPASFWEK
130	140	150	160	170	180
DCKIIYLCRN	AKDVAVSFYY	FFLMVAGHPN	PGSFPEFVEK	FMQGQVPYGS	WYKHVKSWWE
190	200	210	220	230	240
KGKSPRVLFL	FYEDLKEDIR	KEVIKLIHFL	ERKPSEELVD	RIIHHTSFQE	MKNNPSTNYT
250	260	270	280	290
TLPDEIMNQK	LSPFMRKGIT	GDWKNHFTVA	LNEKFDKHYE	QQMKESTLKF	RTEI