AiPD: Autoinhibited Protein Database

Q06520

Gene name	SULT2A1 (HST, STD)
Protein name	Sulfotransferase 2A1
Names	ST2A1, Bile salt sulfotransferase, Dehydroepiandrosterone sulfotransferase, DHEA-ST, DHEA-ST8, Hydroxysteroid Sulfotransferase, HST, ST2, SULT2A3
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6822
EC number	2.8.2.2: Sulfotransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

189-276 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

189-276 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

8 structures for Q06520

Entry ID	Method	Resolution	Chain	Position	Source
1EFH	X-ray	240 A	A/B	1-281	PDB
1J99	X-ray	199 A	A	2-285	PDB
1OV4	X-ray	270 A	A	2-285	PDB
2QP3	X-ray	260 A	A	2-285	PDB
2QP4	X-ray	300 A	A	2-285	PDB
3F3Y	X-ray	220 A	A/B/C/D	1-285	PDB
4IFB	X-ray	230 A	A/B	1-285	PDB
AF-Q06520-F1	Predicted				AlphaFoldDB

236 variants for Q06520

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs989081337 CA309239504	2	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA406639168 rs989081337	2	S>W		No	ClinGen TOPMed
CA9544970 rs750713459	4	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs750713459 CA9544971	4	D>Y		No	ClinGen ExAC gnomAD
TCGA novel	6	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1350928234 CA406639136	7	W>*		No	ClinGen gnomAD
CA309239480 rs750182780	7	W>*		No	ClinGen Ensembl
rs761884884 CA9544968	7	W>G		No	ClinGen ExAC gnomAD
rs1444730798 CA406639114	10	G>R		No	ClinGen gnomAD
CA406639115 rs1444730798	10	G>S		No	ClinGen gnomAD
CA406639110 rs1387776793	10	G>V		No	ClinGen TOPMed
CA309239471 rs914455729	14	P>A		No	ClinGen TOPMed gnomAD
CA9544965 rs759574847	14	P>L		No	ClinGen ExAC TOPMed gnomAD
CA406639087 rs914455729	14	P>S		No	ClinGen TOPMed gnomAD
CA9544964 rs774254425	15	T>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs151119240 CA9544963	16	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs748882283 CA9544962	17	G>D		No	ClinGen ExAC TOPMed gnomAD
rs777552791 CA9544961	19	R>S		No	ClinGen ExAC gnomAD
rs955869493 CA309239463	19	R>T		No	ClinGen TOPMed
rs181193745 CA309239460	21	E>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9544958 rs780703704	21	E>D		No	ClinGen ExAC gnomAD
rs181193745 CA9544959	21	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1030604616 CA309239448	22	T>I		No	ClinGen TOPMed gnomAD
CA406639018 rs1423173698	24	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1600044384 CA406638988	26	V>G		No	ClinGen Ensembl
COSM998822 CA9544954 rs781199635	27	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA9544953 rs758864007	27	R>H		No	ClinGen ExAC gnomAD
CA9544951 rs765438555	28	D>G		No	ClinGen ExAC TOPMed gnomAD
CA406638974 rs1453723177	28	D>N		No	ClinGen TOPMed gnomAD
rs11083907 CA406638932 CA406638935	30	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA406638943 rs1600044355	30	F>L		No	ClinGen Ensembl
CA309239422 rs17851828	30	F>S		No	ClinGen Ensembl
CA406638931 rs1224724913	31	V>M		No	ClinGen gnomAD
rs764307310 CA9544948	32	I>T		No	ClinGen ExAC gnomAD
rs746681436 CA406638899	33	R>M		No	ClinGen gnomAD
TCGA novel	33	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746681436 CA309239405	33	R>T		No	ClinGen gnomAD
CA309239400 rs140689729	34	D>N		No	ClinGen ESP TOPMed
CA9544947 rs759526164	36	D>N		No	ClinGen ExAC
rs964465274 CA309239394	37	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA9544946 rs774491560	39	I>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	40	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1026088302 CA309239392	40	L>S		No	ClinGen Ensembl
rs762746830 CA9544944	41	T>A		No	ClinGen ExAC gnomAD
rs1481416290 CA406638782	42	Y>*		No	ClinGen gnomAD
rs1176871720 CA406638792	42	Y>H		No	ClinGen TOPMed gnomAD
CA406638779 rs1417222490	43	P>T		No	ClinGen TOPMed gnomAD
rs772897551 VAR_083881 CA9544943	44	K>E	sulfating activity toward both DHEA and pregnenolone is completely abolished [UniProt]	No	ClinGen UniProt ExAC dbSNP gnomAD
CA406638762 rs1475428758	44	K>T		No	ClinGen TOPMed gnomAD
rs749519618 CA9544913	48	N>D		No	ClinGen ExAC gnomAD
rs144058411 CA9544912	50	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
COSM164686 CA406638574 rs1385507037	52	E>D	breast [Cosmic]	No	ClinGen cosmic curated gnomAD
CA309237925 rs972423172	57	M>T		No	ClinGen TOPMed
CA309237920 rs373097856	58	H>P		No	ClinGen ESP TOPMed
TCGA novel	59	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1176987252 CA406638530	59	S>P		No	ClinGen gnomAD
CA406638507 rs1367291244	62	D>G		No	ClinGen TOPMed
TCGA novel	62	D>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9544908 rs11569681 VAR_052520 RCV000961665	63	A>P		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA406638492 rs1254523842	64	K>N		No	ClinGen gnomAD
rs1283088941 CA406638487	65	W>*		No	ClinGen TOPMed
rs1220380467 CA406638480	66	I>V		No	ClinGen gnomAD
rs1315342366 CA406638450	70	P>R		No	ClinGen gnomAD
CA406638452 rs1247329786	70	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA9544906 rs765075147	72	W>*		No	ClinGen ExAC TOPMed gnomAD
rs1600041112 CA406638435	72	W>C		No	ClinGen Ensembl
rs761528504 CA9544905	73	E>G		No	ClinGen ExAC TOPMed gnomAD
CA9544904 rs62529832	74	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA9544903 rs763687131	74	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
COSM712132 rs760347203 CA9544902	75	S>*	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1600041069 CA406638423	75	S>T		No	ClinGen Ensembl
CA9544901 VAR_083882 rs775030275	76	P>T	decreases of the sulfotransferase activity toward DHEA; decreases of the sulfotransferase activity toward pregnenolone [UniProt]	No	ClinGen UniProt ExAC dbSNP gnomAD
CA406638410 rs1451267917	77	W>*		No	ClinGen gnomAD
rs1173056628 CA406638406	77	W>C		No	ClinGen gnomAD
CA9544900 rs369760395	79	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA309237856 rs954976546	79	E>Q		No	ClinGen TOPMed
rs555815288 CA9544899	82	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA406638367 rs1414880298	83	G>E		No	ClinGen gnomAD
CA406638370 rs1419998849	83	G>R		No	ClinGen gnomAD
rs749616468 CA9544896	87	L>F		No	ClinGen ExAC gnomAD
CA9544895 rs567166520 COSM998820	90	T>M	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs1260309562 CA406638307	92	S>I		No	ClinGen gnomAD
CA406638302 rs1426455235	93	P>T		No	ClinGen gnomAD
rs755073119 CA9544891	94	R>C		No	ClinGen ExAC gnomAD
rs751662500 CA406638294	94	R>H		No	ClinGen ExAC TOPMed gnomAD
CA406638293 rs751662500	94	R>L		No	ClinGen ExAC TOPMed gnomAD
CA9544890 rs751662500	94	R>P		No	ClinGen ExAC TOPMed gnomAD
rs1390653175 CA406638284	96	F>L		No	ClinGen TOPMed
rs757208013 CA9544888	96	F>S		No	ClinGen ExAC TOPMed gnomAD
rs1383819713 CA406638268	98	S>C		No	ClinGen gnomAD
rs1449632879 CA406638262	99	H>P		No	ClinGen TOPMed
rs760295858 CA406638257	100	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1391358905 CA406638255	100	L>P		No	ClinGen gnomAD
CA9544884 rs760295858	100	L>V		No	ClinGen ExAC TOPMed gnomAD
CA406638247 rs1211204087	102	I>V		No	ClinGen Ensembl
rs752348210 CA9544883	103	Q>R		No	ClinGen ExAC
CA406638225 rs1485730753	105	F>L		No	ClinGen gnomAD
CA9544881 rs758904710	107	K>N		No	ClinGen ExAC TOPMed gnomAD
rs999268893 CA309237794	108	S>F		No	ClinGen TOPMed
rs186827680 CA9544880	111	S>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs377270215 CA309237782	111	S>I		No	ClinGen ESP TOPMed
rs377270215 CA309237785	111	S>N		No	ClinGen ESP TOPMed
rs1443036677 CA406638177	112	S>T		No	ClinGen TOPMed
rs771516118 CA406638167	113	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1201118715 CA406638170	113	K>T		No	ClinGen gnomAD
rs1600040874 CA406638152	115	K>N		No	ClinGen Ensembl
CA9544861 rs763534870	116	V>M		No	ClinGen ExAC gnomAD
CA9544859 rs762023981 CA9544858	120	M>I		No	ClinGen ExAC gnomAD
CA9544860 rs773917138	120	M>T		No	ClinGen ExAC TOPMed gnomAD
CA406638065 rs1251384720	122	N>S		No	ClinGen gnomAD
TCGA novel	124	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	129	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9544855 rs747295631	130	G>A		No	ClinGen ExAC TOPMed gnomAD
CA9544856 rs375232202	130	G>S		No	ClinGen ESP ExAC gnomAD
rs747295631 CA9544854	130	G>V		No	ClinGen ExAC TOPMed gnomAD
CA9544852 rs780085343	132	F>L		No	ClinGen ExAC gnomAD
TCGA novel	133	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	134	W>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs555280855 CA9544851	135	K>E		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	137	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1396324408 CA406637857	138	K>M		No	ClinGen TOPMed gnomAD
CA9544849 rs749217830	141	K>E		No	ClinGen ExAC
CA9544847 rs756091684	143	P>Q		No	ClinGen ExAC gnomAD
rs1568640174 CA406637793	143	P>S		No	ClinGen Ensembl
rs1389092731 CA406637779	144	K>N		No	ClinGen TOPMed
rs781073099 CA9544845	146	W>*		No	ClinGen ExAC gnomAD
CA9544844 rs754560843	146	W>*		No	ClinGen ExAC gnomAD
CA406637766 rs1462170807	146	W>R		No	ClinGen TOPMed
VAR_083883 rs751309613 CA9544843	147	E>K	decreases of the sulfotransferase activity toward DHEA; no effect on the sulfotransferase activity toward pregnenolone [UniProt]	No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
VAR_083884 rs368067020 CA9544842	148	E>K	Variant assessed as Somatic; 0.0 impact. decreases of the sulfotransferase activity toward DHEA; decreases of the sulfotransferase activity toward pregnenolone [NCI-TCGA, UniProt]	No	ClinGen UniProt ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs1437176746 CA406637724	149	Y>H		No	ClinGen gnomAD
CA406637702 rs1251093322	150	F>C		No	ClinGen gnomAD
rs1206719395 CA406637699	150	F>L		No	ClinGen gnomAD
CA406637670 rs1290365762	152	W>C		No	ClinGen gnomAD
CA9544841 rs139437036	152	W>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs202030683 CA9544840	153	F>C		No	ClinGen ExAC gnomAD
CA406637665 rs1323415556	153	F>L		No	ClinGen TOPMed
rs982751588 CA309237089	156	G>A		No	ClinGen Ensembl
rs764839731 CA9544820	160	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA406637599 rs1389175056	160	Y>H		No	ClinGen gnomAD
CA9544819 rs757683079	161	G>W		No	ClinGen ExAC TOPMed gnomAD
CA9544818 rs754425624	163	W>*		No	ClinGen ExAC TOPMed gnomAD
CA9544817 CA309235606 rs200731291	163	W>C		No	ClinGen 1000Genomes ExAC gnomAD
COSM3720360 rs767819209 CA309235602	165	D>N	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated Ensembl
rs775847836 CA9544815	168	H>R		No	ClinGen ExAC gnomAD
rs928731908 CA406637527	170	W>*		No	ClinGen gnomAD
CA309235600 rs928731908	170	W>C		No	ClinGen gnomAD
rs1269238469 CA406637519	171	M>I		No	ClinGen gnomAD
CA9544814 rs767678575	172	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1200431372 CA406637507	173	M>I		No	ClinGen TOPMed
rs774264978 CA9544812	173	M>R		No	ClinGen ExAC gnomAD
CA406637508 rs774264978	173	M>T		No	ClinGen ExAC gnomAD
CA9544813 rs759786814	173	M>V		No	ClinGen ExAC TOPMed gnomAD
rs771096303 CA9544811	175	E>*		No	ClinGen ExAC gnomAD
rs748025835 CA9544810	175	E>A		No	ClinGen ExAC TOPMed gnomAD
CA9544809 rs776701058	176	E>K		No	ClinGen ExAC TOPMed gnomAD
rs147230706 CA9544808	177	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	181	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA406637441 rs1467995597	183	S>N		No	ClinGen gnomAD
rs544733723 CA309235575	184	Y>H		No	ClinGen gnomAD
rs780023162 CA9544805	185	E>K		No	ClinGen ExAC gnomAD
rs1600035311 CA406637411	187	L>P		No	ClinGen Ensembl
CA309235568 rs969882784	188	K>N		No	ClinGen Ensembl
rs1416845694 CA406637391	189	Q>*		No	ClinGen gnomAD
rs888475801 CA309233737	192	G>R		No	ClinGen TOPMed
CA9544786 rs775399658	194	T>I		No	ClinGen ExAC gnomAD
CA406637025 rs775399658	194	T>N		No	ClinGen ExAC gnomAD
rs1484531915 CA406637017	196	E>K		No	ClinGen gnomAD
CA9544784 rs371975368	199	C>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA406636980 rs1276841213	200	Q>H		No	ClinGen gnomAD
CA9544782 rs770501427	203	G>E		No	ClinGen ExAC gnomAD
rs748785131 CA9544781	204	K>Q		No	ClinGen ExAC gnomAD
CA9544780 rs529798485	205	T>K		No	ClinGen ExAC TOPMed
CA309233715 rs529798485	205	T>M		No	ClinGen ExAC TOPMed
CA9544778 rs753252958	207	E>A		No	ClinGen ExAC
CA9544776 rs147399625	208	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs370526585 CA9544773	209	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA406636830 rs1307382428	213	L>*		No	ClinGen gnomAD
TCGA novel	215	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9544772 rs763112217	216	K>E		No	ClinGen ExAC gnomAD
rs377180978 CA9544771	216	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA406636780 rs1568637387	217	N>H		No	ClinGen Ensembl
TCGA novel	217	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1423607864 CA406636758	218	S>N		No	ClinGen gnomAD
CA406636756 rs1423607864	218	S>T		No	ClinGen gnomAD
CA406636745 rs1249352984	219	S>P		No	ClinGen TOPMed
rs772139550 CA9544767	222	S>N		No	ClinGen ExAC gnomAD
rs759315831 CA9544766	223	M>L		No	ClinGen ExAC gnomAD
CA406636683 rs1254155846	225	E>*		No	ClinGen gnomAD
CA9544765 rs774037082	226	N>S		No	ClinGen ExAC TOPMed gnomAD
rs11569680 CA309233675	227	K>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs11569680 CA9544763 RCV000879187	227	K>E		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs11569680 CA9544764	227	K>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9544762 rs772686936	228	M>T		No	ClinGen ExAC TOPMed gnomAD
CA9544761 rs769353265	229	S>F		No	ClinGen ExAC gnomAD
CA9544759 rs148329743	230	N>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs148329743 CA9544760	230	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA406636630 rs1173559793	230	N>Y		No	ClinGen TOPMed
rs1352184597 CA406636592	233	L>I		No	ClinGen TOPMed gnomAD
CA406636590 rs1352184597	233	L>V		No	ClinGen TOPMed gnomAD
rs747352904 CA9544757	235	S>G		No	ClinGen ExAC gnomAD
rs1392182520 CA406636567	235	S>N		No	ClinGen TOPMed
CA9544756 rs780320337	239	V>L		No	ClinGen ExAC gnomAD
CA406636478 rs1368495524	241	D>E		No	ClinGen TOPMed
CA406636444 rs750664796	244	Q>P		No	ClinGen ExAC TOPMed gnomAD
CA9544754 rs750664796	244	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs190776413 CA9544753	245	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs757338859 VAR_083885 CA9544752	246	L>P	decreases of the sulfotransferase activity toward DHEA; decreases of the sulfotransferase activity toward pregnenolone [UniProt]	No	ClinGen UniProt ExAC dbSNP gnomAD
CA309233650 rs912944182	247	R>T		No	ClinGen TOPMed
CA309233648 rs947041469	249	G>S		No	ClinGen TOPMed
CA9544737 rs758752472	250	V>A		No	ClinGen ExAC gnomAD
rs1426974048 CA406636311	252	G>R		No	ClinGen gnomAD
rs1189011400 CA406636264	254	W>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA406636274 rs1186426230	254	W>*		No	ClinGen TOPMed
CA309232219 rs866659042	255	K>R		No	ClinGen Ensembl
rs1466120788 CA406636238	256	N>S		No	ClinGen gnomAD
CA9544734 VAR_083886 rs779218418	258	F>L	decreases of the sulfotransferase activity toward DHEA; decreases of the sulfotransferase activity toward pregnenolone [UniProt]	No	ClinGen UniProt ExAC dbSNP gnomAD
VAR_083886 CA9544735 rs746239667	258	F>L	decreases of the sulfotransferase activity toward DHEA; decreases of the sulfotransferase activity toward pregnenolone [UniProt]	No	ClinGen UniProt ExAC dbSNP gnomAD
VAR_052521 CA9544733 rs11569679	261	A>T		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs753928755 VAR_083887 CA9544732	262	Q>E	decreases of the sulfotransferase activity toward DHEA; no effect on the sulfotransferase activity toward pregnenolone [UniProt]	No	ClinGen UniProt ExAC dbSNP gnomAD
CA309232212 rs753928755	262	Q>K		No	ClinGen ExAC gnomAD
CA9544731 rs764311389	263	A>G		No	ClinGen ExAC gnomAD
rs754922906 CA9544730	264	E>A		No	ClinGen ExAC TOPMed gnomAD
rs1568636259 CA406636120	265	D>N		No	ClinGen Ensembl
CA9544728 rs751509523 COSM1525576	269	L>F	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs750526898 CA309232202	270	F>S		No	ClinGen Ensembl
rs1225285029 CA406636022	274	M>I		No	ClinGen Ensembl
CA406636026 rs766193413	274	M>K		No	ClinGen ExAC TOPMed gnomAD
CA9544727 rs766193413	274	M>T		No	ClinGen ExAC TOPMed gnomAD
CA406636029 rs1395957589	274	M>V		No	ClinGen gnomAD
TCGA novel	277	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA309232199 rs1032191564	278	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs149563641 CA9544726	279	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA9544724 rs764823849	283	P>S		No	ClinGen ExAC gnomAD
rs1442952150 CA406635869 COSM3797331 CA406635868	284	W>R	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA309232183 rs1013330593	285	E>D		No	ClinGen Ensembl

No associated diseases with Q06520

1 regional properties for Q06520

Type	Name	Position	InterPro Accession
domain	Sulfotransferase domain	34 - 277	IPR000863

Functions

		Description
EC Number	2.8.2.2	Sulfotransferases
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

5 GO annotations of molecular function

Name	Definition
3'-phosphoadenosine 5'-phosphosulfate binding	Binding to 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems.
alcohol sulfotransferase activity	Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate.
bile-salt sulfotransferase activity	Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate.
steroid sulfotransferase activity	Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate.
sulfotransferase activity	Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.

9 GO annotations of biological process

Name	Definition
3'-phosphoadenosine 5'-phosphosulfate metabolic process	The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems.
bile acid catabolic process	The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile.
cholesterol metabolic process	The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
ethanol catabolic process	The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation.
lipid catabolic process	The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
steroid metabolic process	The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
sulfation	The addition of a sulfate group to a molecule.
thyroid hormone metabolic process	The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.
xenobiotic metabolic process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

11 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P19217	SULT1E1	Sulfotransferase 1E1	Bos taurus (Bovine)	PR
P49888	SULT1E1	Sulfotransferase 1E1	Homo sapiens (Human)	PR
Q9BR01	SULT4A1	Sulfotransferase 4A1	Homo sapiens (Human)	PR
P49891	Sult1e1	Sulfotransferase 1E1	Mus musculus (Mouse)	PR
O35403	Sult3a1	Amine sulfotransferase	Mus musculus (Mouse)	PR
Q3UZZ6	Sult1d1	Sulfotransferase 1 family member D1	Mus musculus (Mouse)	PR
P0CC03	Sult6b1	Sulfotransferase 6B1	Mus musculus (Mouse)	PR
P49890	Ste2	Estrogen sulfotransferase Ste2	Rattus norvegicus (Rat)	PR
P17988	Sult1a1	Sulfotransferase 1A1	Rattus norvegicus (Rat)	PR
Q9FX55	STO9	Cytosolic sulfotransferase 9	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9STQ6	SOT3	Cytosolic sulfotransferase 3	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MSDDFLWFEG	IAFPTMGFRS	ETLRKVRDEF	VIRDEDVIIL	TYPKSGTNWL	AEILCLMHSK
70	80	90	100	110	120
GDAKWIQSVP	IWERSPWVES	EIGYTALSET	ESPRLFSSHL	PIQLFPKSFF	SSKAKVIYLM
130	140	150	160	170	180
RNPRDVLVSG	YFFWKNMKFI	KKPKSWEEYF	EWFCQGTVLY	GSWFDHIHGW	MPMREEKNFL
190	200	210	220	230	240
LLSYEELKQD	TGRTIEKICQ	FLGKTLEPEE	LNLILKNSSF	QSMKENKMSN	YSLLSVDYVV
250	260	270	280
DKAQLLRKGV	SGDWKNHFTV	AQAEDFDKLF	QEKMADLPRE	LFPWE