AiPD: Autoinhibited Protein Database

Q9BR01

Gene name	SULT4A1 (SULTX3)
Protein name	Sulfotransferase 4A1
Names	ST4A1, Brain sulfotransferase-like protein, hBR-STL, hBR-STL-1, Nervous system sulfotransferase, NST
Species	Homo sapiens (Human)
KEGG Pathway	hsa:25830
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-44 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-44 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q9BR01

Entry ID	Method	Resolution	Chain	Position	Source
1ZD1	X-ray	224 A	A/B	1-284	PDB
AF-Q9BR01-F1	Predicted				AlphaFoldDB

197 variants for Q9BR01

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA10277269 rs768026959	2	A>V		No	ClinGen ExAC gnomAD
TCGA novel	3	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs903939763 CA324868173	4	S>I		No	ClinGen TOPMed gnomAD
CA411853994 rs903939763	4	S>N		No	ClinGen TOPMed gnomAD
TCGA novel	5	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411853963 rs1194587288	8	T>I		No	ClinGen gnomAD
COSM133453 rs1433107320 CA411853959	9	P>A	ovary [Cosmic]	No	ClinGen cosmic curated gnomAD
rs766972038 CA10277266	10	S>G		No	ClinGen ExAC gnomAD
TCGA novel	10	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA324868172 rs1043796910	13	G>E		No	ClinGen TOPMed
CA411853934 rs1224237248	13	G>R		No	ClinGen TOPMed
CA411853926 rs1469551019	14	E>G		No	ClinGen gnomAD
CA411853909 rs1183877631	15	F>L		No	ClinGen gnomAD
rs1603410897 CA411853918	15	F>V		No	ClinGen Ensembl
rs550696475 CA10277262	21	E>D		No	ClinGen 1000Genomes ExAC gnomAD
CA411853796 rs1603410895	22	F>L		No	ClinGen Ensembl
rs1228117741 CA411853793	23	H>N		No	ClinGen gnomAD
rs1228117741 CA411853791	23	H>Y		No	ClinGen gnomAD
CA10277259 rs746904933	28	P>A		No	ClinGen ExAC gnomAD
rs1209109909 CA411853715	29	P>S		No	ClinGen gnomAD
CA411853684 rs1408410792	31	C>S		No	ClinGen gnomAD
rs779842210 CA10277258	35	M>T		No	ClinGen ExAC gnomAD
rs377607389 CA324868167	35	M>V		No	ClinGen ESP TOPMed
CA10277257 rs772114318	37	E>D		No	ClinGen ExAC gnomAD
rs376147023 CA10277256	39	A>S		No	ClinGen ESP ExAC gnomAD
rs1195925808 CA411853483	40	N>D		No	ClinGen gnomAD
rs375314237 CA10277255	40	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA10277252 rs781644083	46	S>G		No	ClinGen ExAC gnomAD
CA411853332 rs1166668764	46	S>N		No	ClinGen TOPMed
rs1347105011 CA411853318	47	D>N		No	ClinGen gnomAD
CA10277250 rs752032171	48	V>L		No	ClinGen ExAC gnomAD
CA411853251 rs1226083989	51	V>L		No	ClinGen gnomAD
CA324868164 rs372579970	52	T>S		No	ClinGen ESP TOPMed
CA324862609 rs930807200	57	G>A		No	ClinGen Ensembl
TCGA novel	57	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10277246 rs765329665	57	G>R		No	ClinGen ExAC gnomAD
rs780214138 CA10277214	59	S>G		No	ClinGen ExAC TOPMed gnomAD
CA411849418 rs1325608117	59	S>N		No	ClinGen gnomAD
CA10277213 rs758800944	63	E>D		No	ClinGen ExAC gnomAD
CA411849383 rs1603407065	64	V>G		No	ClinGen Ensembl
CA411849386 rs1410685224	64	V>M		No	ClinGen TOPMed
rs1408673077 CA411849357	68	V>L		No	ClinGen Ensembl
rs920743123 CA324862600	72	A>T		No	ClinGen TOPMed gnomAD
CA411849325 rs1463093188	73	D>N		No	ClinGen TOPMed
rs757800797 CA10277210	74	P>R		No	ClinGen ExAC gnomAD
TCGA novel	74	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	75	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs371468251 CA10277208	75	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA411849306 rs1298511366	76	E>K		No	ClinGen TOPMed
CA411849287 rs1287648601	78	G>A		No	ClinGen TOPMed
CA10277205 rs144542554	78	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1334854209 CA411849285	79	L>M		No	ClinGen TOPMed
CA411849277 rs1307054107	80	M>V		No	ClinGen gnomAD
CA411849269 rs1270971942	81	N>H		No	ClinGen gnomAD
CA411849264 rs1234575553	81	N>S		No	ClinGen TOPMed
CA411849260 rs1216874534	82	I>V		No	ClinGen gnomAD
rs774324106 CA10277203	83	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1327431018 CA411849211	87	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs772560635 CA10277200	88	V>A		No	ClinGen ExAC gnomAD
rs11542810 CA324862581	88	V>F		No	ClinGen Ensembl
rs772560635 CA411849189	88	V>G		No	ClinGen ExAC gnomAD
CA411849150 rs1603407021	91	Y>D		No	ClinGen Ensembl
rs1351549063 CA411849134	92	P>S		No	ClinGen gnomAD
rs1411613196 CA411849094	94	P>L		No	ClinGen TOPMed gnomAD
TCGA novel	95	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1172789638 CA411849089	95	G>S		No	ClinGen gnomAD
rs373009041 CA10277198	96	L>M		No	ClinGen ESP ExAC gnomAD
rs768365734 CA10277196	99	I>V		No	ClinGen ExAC gnomAD
TCGA novel	100	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1350650615 CA411848462	103	T>I		No	ClinGen gnomAD
rs771297700 CA10277175	104	S>P		No	ClinGen ExAC gnomAD
rs771297700 CA10277174	104	S>T		No	ClinGen ExAC gnomAD
CA10277173 rs749670426	104	S>Y		No	ClinGen ExAC gnomAD
rs1229680658 CA411848449	106	R>C		No	ClinGen TOPMed
rs778336831 CA411848442	107	L>F		No	ClinGen ExAC gnomAD
rs778336831 CA10277172	107	L>V		No	ClinGen ExAC gnomAD
rs1044383208 CA324861794	109	K>E		No	ClinGen Ensembl
rs1452695461 CA411848422	110	S>N		No	ClinGen gnomAD
CA411848399 rs1277392551	113	P>L		No	ClinGen TOPMed
CA324861783 rs74710439	114	Y>C		No	ClinGen Ensembl
CA324861785 rs74710439	114	Y>S		No	ClinGen Ensembl
rs546220184 CA10277171	115	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1238149450 CA411848376	117	L>P		No	ClinGen TOPMed
TCGA novel	118	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411848347 rs1185871949	122	H>D		No	ClinGen TOPMed gnomAD
rs1185871949 CA411848348	122	H>N		No	ClinGen TOPMed gnomAD
CA411848344 rs1413910881	122	H>R		No	ClinGen TOPMed gnomAD
rs138632722 CA10277168	123	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA411848317 rs1204933059	126	S>A		No	ClinGen gnomAD
CA10277150 rs781358478	129	I>F		No	ClinGen ExAC gnomAD
rs768874631 CA10277149	130	Y>C		No	ClinGen ExAC gnomAD
CA10277148 rs747147345	132	A>S		No	ClinGen ExAC gnomAD
rs780422178 CA10277147	132	A>V		No	ClinGen ExAC gnomAD
rs758590711 CA10277146	133	R>H		No	ClinGen ExAC TOPMed gnomAD
CA411848258 rs758590711	133	R>P		No	ClinGen ExAC TOPMed gnomAD
rs1205273281 CA411848238	136	K>R		No	ClinGen TOPMed
CA411848217 rs1241070926	139	V>G		No	ClinGen TOPMed
rs1603406154 CA411848209	140	V>G		No	ClinGen Ensembl
rs1472390119 CA411848213	140	V>L		No	ClinGen TOPMed
rs1169633486 CA639554224	143	Y>*		No	ClinGen gnomAD
TCGA novel	144	Q>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757178565 CA10277143	147	R>C		No	ClinGen ExAC gnomAD
rs753786397 CA10277142	147	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1267500349 CA411848070	150	R>Q		No	ClinGen gnomAD
CA411848073 rs1389024395	150	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs11542811 CA10277140	155	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	156	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1337373747 CA411847878	162	C>S		No	ClinGen gnomAD
CA10277139 rs752241300	166	M>V		No	ClinGen ExAC
rs1406331692 CA411847802	167	N>S		No	ClinGen TOPMed
rs1283291547 CA411846750	172	Y>H		No	ClinGen gnomAD
rs549956106 CA411846685	177	E>D		No	ClinGen 1000Genomes ExAC gnomAD
rs867922374 CA324858941	178	H>Y		No	ClinGen Ensembl
CA411846676 rs761288727	179	V>L		No	ClinGen ExAC TOPMed gnomAD
CA10277110 rs761288727	179	V>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	181	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411846657 rs1286524907	181	E>D		No	ClinGen gnomAD
CA411846635 rs1437368866	184	E>G		No	ClinGen TOPMed
CA411846628 rs1603404669	185	H>P		No	ClinGen Ensembl
rs1316438809 CA411846630	185	H>Y		No	ClinGen TOPMed
rs772050368 CA10277108	186	R>C		No	ClinGen ExAC TOPMed gnomAD
rs746018922 CA10277107	186	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA10277106 rs774430941	187	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1390331172 CA411846595	189	S>L		No	ClinGen TOPMed gnomAD
CA411846597 rs1390331172	189	S>W		No	ClinGen TOPMed gnomAD
rs200573111 CA10277103	190	N>K		No	ClinGen 1000Genomes ExAC gnomAD
CA10277102 rs150172622	191	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs150172622 CA10277101	191	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA324858882 rs930677322	192	L>F		No	ClinGen TOPMed
TCGA novel	194	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411846470 rs1310921887	197	E>D		No	ClinGen gnomAD
CA324858880 rs913655527	198	D>Y		No	ClinGen Ensembl
CA10277099 rs754438199	199	M>T		No	ClinGen ExAC TOPMed gnomAD
CA411846431 rs372936779	200	H>N		No	ClinGen ESP gnomAD
CA411846424 rs1176258669	200	H>R		No	ClinGen TOPMed
CA324858876 rs372936779	200	H>Y		No	ClinGen ESP gnomAD
CA10277098 rs751151043	201	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs752151481 CA324858875	201	R>W		No	ClinGen Ensembl
CA411845196 rs1191856085	202	D>E		No	ClinGen gnomAD
rs572334857 CA10277065	205	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs572334857 CA411845179	205	T>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs373715190 CA324856324	206	M>K		No	ClinGen ESP TOPMed
rs373715190 CA411845174	206	M>T		No	ClinGen ESP TOPMed
rs767434628 CA324856304	209	Q>H		No	ClinGen ExAC gnomAD
rs1310081712 CA411845127	212	R>S		No	ClinGen gnomAD
CA411845108 rs1302881553	213	F>L		No	ClinGen gnomAD
rs1219436016 CA411845099	214	L>Q		No	ClinGen gnomAD
rs954854963 CA411845083	215	G>E		No	ClinGen gnomAD
rs954854963 CA324856284	215	G>V		No	ClinGen gnomAD
rs1285884869 CA411845080	216	V>M		No	ClinGen gnomAD
CA411845042 rs1206557885	218	C>Y		No	ClinGen Ensembl
CA324856281 rs1045893919	220	K>N		No	ClinGen TOPMed gnomAD
rs1371043517 CA411845002	220	K>T		No	ClinGen gnomAD
rs1360666849 CA411844986	221	A>D		No	ClinGen gnomAD
rs1464303215 CA411844992	221	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1418694141 CA411844976	222	Q>*		No	ClinGen gnomAD
rs1409918962 CA411844929	224	E>D		No	ClinGen gnomAD
rs779364979 CA10277061	225	A>T		No	ClinGen ExAC TOPMed gnomAD
rs771722462 CA10277060	226	L>P		No	ClinGen ExAC gnomAD
rs1257352010 CA411844893	227	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1210445887 CA411844842	230	C>Y		No	ClinGen gnomAD
CA411844813 rs983681242	231	H>Q		No	ClinGen TOPMed gnomAD
rs1229779292 CA411844787	233	L>V		No	ClinGen gnomAD
CA411844776 rs1229626108	234	V>M		No	ClinGen TOPMed gnomAD
CA324856255 rs900773297	237	C>S		No	ClinGen Ensembl
CA411844688 rs1351045890	239	N>D		No	ClinGen gnomAD
CA10277058 rs778676756	239	N>K		No	ClinGen ExAC TOPMed gnomAD
rs17852026 CA324856253	239	N>S		No	ClinGen Ensembl
TCGA novel	240	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411844669 rs1294689069	240	A>T		No	ClinGen gnomAD
CA10277056 rs757017007	242	A>D		No	ClinGen ExAC
CA411844628 rs1405182983	244	P>S		No	ClinGen TOPMed
CA411844616 rs1303193737	245	V>M		No	ClinGen TOPMed gnomAD
rs373947609 CA411844580	247	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA10277051 rs373947609	247	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA411844584 rs1386679724	247	R>W		No	ClinGen TOPMed gnomAD
CA411843840 rs1180774998	250	V>A		No	ClinGen gnomAD
CA411843838 rs1180774998	250	V>G		No	ClinGen gnomAD
CA411843783 rs1307316834	253	W>*		No	ClinGen gnomAD
rs1182419016 CA411843693	256	I>V		No	ClinGen gnomAD
CA411843643 rs1430030946	258	T>I		No	ClinGen TOPMed
COSM300923 CA10276999 rs374057069	259	V>I	large_intestine Variant assessed as Somatic; 4.62e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs762497351 CA10276998	260	S>P		No	ClinGen ExAC gnomAD
CA10276997 rs772650231	261	M>T		No	ClinGen ExAC gnomAD
rs769443791 CA10276996	262	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1289593688 CA411843408	266	D>E		No	ClinGen gnomAD
rs1282924627 CA411843398	267	L>V		No	ClinGen TOPMed
CA10276994 rs775766086	272	K>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	275	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA324854516 rs771252692	275	K>R		No	ClinGen Ensembl
CA10276993 rs772439968	276	C>R		No	ClinGen ExAC gnomAD
rs1456527697 CA411843165	278	L>F		No	ClinGen gnomAD
CA10276991 rs540773885	279	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1183291763 CA411843150	280	F>L		No	ClinGen TOPMed gnomAD
CA411843147 rs1473870748	280	F>S		No	ClinGen TOPMed gnomAD
CA411843151 rs1183291763	280	F>V		No	ClinGen TOPMed gnomAD
rs889775222 CA324854504	281	D>G		No	ClinGen Ensembl

No associated diseases with Q9BR01

1 regional properties for Q9BR01

Type	Name	Position	InterPro Accession
domain	Sulfotransferase domain	45 - 276	IPR000863

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name	Definition
identical protein binding	Binding to an identical protein or proteins.
sulfotransferase activity	Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.

3 GO annotations of biological process

Name	Definition
dendrite arborization	The process in which the anatomical structures of a dendritic tree are generated and organized into dendritic branches.
steroid metabolic process	The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
sulfation	The addition of a sulfate group to a molecule.

11 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P19217	SULT1E1	Sulfotransferase 1E1	Bos taurus (Bovine)	PR
Q06520	SULT2A1	Sulfotransferase 2A1	Homo sapiens (Human)	PR
P49888	SULT1E1	Sulfotransferase 1E1	Homo sapiens (Human)	PR
P49891	Sult1e1	Sulfotransferase 1E1	Mus musculus (Mouse)	PR
O35403	Sult3a1	Amine sulfotransferase	Mus musculus (Mouse)	PR
Q3UZZ6	Sult1d1	Sulfotransferase 1 family member D1	Mus musculus (Mouse)	PR
P0CC03	Sult6b1	Sulfotransferase 6B1	Mus musculus (Mouse)	PR
P49890	Ste2	Estrogen sulfotransferase Ste2	Rattus norvegicus (Rat)	PR
P17988	Sult1a1	Sulfotransferase 1A1	Rattus norvegicus (Rat)	PR
Q9FX55	STO9	Cytosolic sulfotransferase 9	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9STQ6	SOT3	Cytosolic sulfotransferase 3	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MAESEAETPS	TPGEFESKYF	EFHGVRLPPF	CRGKMEEIAN	FPVRPSDVWI	VTYPKSGTSL
70	80	90	100	110	120
LQEVVYLVSQ	GADPDEIGLM	NIDEQLPVLE	YPQPGLDIIK	ELTSPRLIKS	HLPYRFLPSD
130	140	150	160	170	180
LHNGDSKVIY	MARNPKDLVV	SYYQFHRSLR	TMSYRGTFQE	FCRRFMNDKL	GYGSWFEHVQ
190	200	210	220	230	240
EFWEHRMDSN	VLFLKYEDMH	RDLVTMVEQL	ARFLGVSCDK	AQLEALTEHC	HQLVDQCCNA
250	260	270	280
EALPVGRGRV	GLWKDIFTVS	MNEKFDLVYK	QKMGKCDLTF	DFYL