P49890

PR
Gene name
Ste2
Protein name
Estrogen sulfotransferase Ste2
Names
Estrogen sulfotransferase, isoform 6, EST-6, Estrone sulfotransferase, Sulfotransferase, estrogen-preferring
Species
Rattus norvegicus (Rat)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

200-283 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for P49890

Entry ID Method Resolution Chain Position Source
No available structures

No variants for P49890

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P49890

No associated diseases with P49890

1 regional properties for P49890

Type Name Position InterPro Accession
domain Sulfotransferase domain 38 - 287 IPR000863

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
aryl sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.
estrone sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate.
steroid binding Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.
sulfotransferase activity Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.

1 GO annotations of biological process

Name Definition
sulfation The addition of a sulfate group to a molecule.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P19217 SULT1E1 Sulfotransferase 1E1 Bos taurus (Bovine) PR
Q06520 SULT2A1 Sulfotransferase 2A1 Homo sapiens (Human) PR
Q9BR01 SULT4A1 Sulfotransferase 4A1 Homo sapiens (Human) PR
P49888 SULT1E1 Sulfotransferase 1E1 Homo sapiens (Human) PR
O35403 Sult3a1 Amine sulfotransferase Mus musculus (Mouse) PR
Q3UZZ6 Sult1d1 Sulfotransferase 1 family member D1 Mus musculus (Mouse) PR
P0CC03 Sult6b1 Sulfotransferase 6B1 Mus musculus (Mouse) PR
P49891 Sult1e1 Sulfotransferase 1E1 Mus musculus (Mouse) PR
P17988 Sult1a1 Sulfotransferase 1A1 Rattus norvegicus (Rat) PR
P49889 Ste Estrogen sulfotransferase, isoform 3 Rattus norvegicus (Rat) PR
Q9FX55 STO9 Cytosolic sulfotransferase 9 Arabidopsis thaliana (Mouse-ear cress) PR
Q9STQ6 SOT3 Cytosolic sulfotransferase 3 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
METSMPEYYE VFGDFHGVLV DKLFTKYWED VETFSARPDD LLVVTYPKSG STWIGEIVDM
70 80 90 100 110 120
IYKEGDVEKC KEDAIFNRIP YLECRNEDLI NGIKQLKEKE SPRIVKTHLP AKLLPASFWE
130 140 150 160 170 180
KNCKIIYLCR NAKDVVVSYY YFFLIIKSYP NPKSFSEFVE KFMEGQVPYG SWYDHVKSWW
190 200 210 220 230 240
EKSKNSRVLF MFYEDMKEDI RREVVKLIEF LERDPLAELV DKIIQHTSFQ EMKNNPCTNY
250 260 270 280 290
SMLPETMIDL KVSPFMRKGI VGDWRNHFPE ALRERFEEHY QRHMKDCPVT FRAEL