P49889
Gene name |
Ste |
Protein name |
Estrogen sulfotransferase, isoform 3 |
Names |
EST-3, Estrone sulfotransferase, Sulfotransferase, estrogen-preferring |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:360268 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
0 structures for P49889
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| No available structures | |||||
No variants for P49889
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P49889 | |||||
No associated diseases with P49889
1 regional properties for P49889
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Sulfotransferase domain | 38 - 287 | IPR000863 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| aryl sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate. |
| estrone sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate. |
| flavonol 3-sulfotransferase activity | Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H(+) + quercetin 3-sulfate. |
| steroid binding | Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. |
| steroid sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate. |
| sulfotransferase activity | Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| 3'-phosphoadenosine 5'-phosphosulfate metabolic process | The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. |
| estrogen catabolic process | The chemical reactions and pathways resulting in the breakdown of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. |
| estrogen metabolic process | The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. |
| ethanol catabolic process | The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. |
| female pregnancy | The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth. |
| positive regulation of fat cell differentiation | Any process that activates or increases the frequency, rate or extent of adipocyte differentiation. |
| sulfation | The addition of a sulfate group to a molecule. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P19217 | SULT1E1 | Sulfotransferase 1E1 | Bos taurus (Bovine) | PR |
| P49888 | SULT1E1 | Sulfotransferase 1E1 | Homo sapiens (Human) | PR |
| P49891 | Sult1e1 | Sulfotransferase 1E1 | Mus musculus (Mouse) | PR |
| P17988 | Sult1a1 | Sulfotransferase 1A1 | Rattus norvegicus (Rat) | PR |
| P49890 | Ste2 | Estrogen sulfotransferase Ste2 | Rattus norvegicus (Rat) | PR |
| Q9STQ6 | SOT3 | Cytosolic sulfotransferase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FX55 | STO9 | Cytosolic sulfotransferase 9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| METSMPEYYD | VFGDFHGFLM | DKRFTKYWED | VETFLARPDD | LLIVTYPKSG | STWISEIVDM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IYKEGDVEKC | KEDALFNRIP | DLECRNEDLI | NGIKQLKEKE | SPRIVKTHLP | AKLLPASFWE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KNCKIIYLCR | NAKDVVVSYY | YFFLIMKSYP | NPKSFSEFVE | KFMEGQVPYG | SWYDHVKSWW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EKSKNSRVLF | MFYEDMKEDI | RREVVKLIEF | LERDPSAELV | DRIIQHTSFQ | EMKNNPCTNY |
| 250 | 260 | 270 | 280 | 290 | |
| SMLPETMIDL | KVSPFMRKGI | VGDWKNHFPE | ALRERFEEHY | QQQMKDCPVK | FRAEL |