P32468
PR
Gene name |
CDC12 (CLA10, PSL7, YHR107C) |
Protein name |
Cell division control protein 12 |
Names |
Septin |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YHR107C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P32468
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P32468-F1 | Predicted | AlphaFoldDB |
5 variants for P32468
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s08-327841 | 67 | H>Y | No | SGRP | |
| s08-327595 | 149 | F>L | No | SGRP | |
| s08-327487 | 185 | T>A | No | SGRP | |
| s08-327486 | 185 | T>I | No | SGRP | |
| s08-327397 | 215 | D>N | No | SGRP |
No associated diseases with P32468
1 regional properties for P32468
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Septin-type guanine nucleotide-binding (G) domain | 31 - 319 | IPR030379 |
Functions
13 GO annotations of cellular component
| Name | Definition |
|---|---|
| ascospore wall | The specialized cell wall of the ascospore (spore), which is the product of meiotic division. Examples of this component are found in Fungi. |
| cell division site | The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. |
| cellular bud neck | The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding. |
| cellular bud neck septin ring | A ring-shaped structure that forms at the site of cytokinesis in the bud neck of a budding cell; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange. |
| cellular bud scar | Crater-like ring of chitinous scar tissue located on the surface of the mother cell. It is formed after the newly emerged daughter cell separates thereby marking the site of cytokinesis and septation. The number of bud scars that accumulate on the surface of a cell is a useful determinant of replicative age. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| Gin4 complex | A protein complex involved in septin ring formation during mitosis. In Saccharomyces cerevisiae it consists of BNI5, CDC3, CDC10, CDC11, CDC12, GIN4, NAP1 and SHS1. At least 2 GIN4 molecules are involved. |
| mating projection | The projection formed by unicellular fungi in response to mating pheromone. |
| microtubule cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. |
| prospore membrane | The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls. An example of this component is found in Schizosaccharomyces pombe. |
| septin complex | A protein complex containing septins. Typically, these complexes contain multiple septins and are oligomeric. |
| septin filament array | Arrays of septin filaments, or bars, found in a series of filamentous structures. Such structures have been observed in the prospore membrane during spore formation in S. cerevisiae and in the chlamydospore membrane during chlamydospore formation in C. albicans. |
| septin ring | A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| molecular adaptor activity | The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. |
| phosphatidylinositol-4-phosphate binding | Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position. |
| phosphatidylinositol-5-phosphate binding | Binding to phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position. |
| structural constituent of cytoskeleton | The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular bud neck septin ring organization | Control of the formation, spatial distribution, and breakdown of a septin ring located at the bud neck. |
| cytoskeleton-dependent cytokinesis | A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton. |
| maintenance of cell polarity | The maintenance of established anisotropic intracellular organization or cell growth patterns. |
| mitotic actomyosin contractile ring assembly | Any actomyosin contractile ring assembly that is involved in mitotic cytokinesis. |
| mitotic cytokinesis | A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. |
| positive regulation of protein kinase activity | Any process that activates or increases the frequency, rate or extent of protein kinase activity. |
| positive regulation of protein serine/threonine kinase activity | Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity. |
| protein localization | Any process in which a protein is transported to, or maintained in, a specific location. |
| septin ring assembly | The aggregation, arrangement and bonding together of septins and associated proteins to form an organized structure resembling a ring at the cell cortex. |
| septum digestion after cytokinesis | The process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis. |
24 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32457 | CDC3 | Cell division control protein 3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q07657 | SHS1 | Seventh homolog of septin 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P25342 | CDC10 | Cell division control protein 10 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| A6QQL3 | SEPTIN14 | Septin-14 | Bos taurus (Bovine) | PR |
| A2VE99 | SEPTIN11 | Septin-11 | Bos taurus (Bovine) | PR |
| Q3SZN0 | SEPTIN6 | Septin-6 | Bos taurus (Bovine) | PR |
| Q6Q137 | SEPTIN7 | Septin-7 | Bos taurus (Bovine) | PR |
| Q5R1W1 | SEPTIN7 | Septin-7 | Pan troglodytes (Chimpanzee) | PR |
| P54359 | 02-Sep | Septin-2 | Drosophila melanogaster (Fruit fly) | PR |
| Q9P0V9 | SEPTIN10 | Septin-10 | Homo sapiens (Human) | PR |
| Q9NVA2 | SEPTIN11 | Septin-11 | Homo sapiens (Human) | PR |
| Q14141 | SEPTIN6 | Septin-6 | Homo sapiens (Human) | PR |
| Q16181 | SEPTIN7 | Septin-7 | Homo sapiens (Human) | PR |
| Q9DA97 | Septin14 | Septin-14 | Mus musculus (Mouse) | PR |
| Q8CHH9 | Septin8 | Septin-8 | Mus musculus (Mouse) | PR |
| Q8C1B7 | Septin11 | Septin-11 | Mus musculus (Mouse) | PR |
| Q9R1T4 | Septin6 | Septin-6 | Mus musculus (Mouse) | PR |
| P28661 | Septin4 | Septin-4 | Mus musculus (Mouse) | PR |
| O55131 | Septin7 | Septin-7 | Mus musculus (Mouse) | PR |
| B0BNF1 | Septin8 | Septin-8 | Rattus norvegicus (Rat) | PR |
| B3GNI6 | Septin11 | Septin-11 | Rattus norvegicus (Rat) | PR |
| Q9WVC0 | Septin7 | Septin-7 | Rattus norvegicus (Rat) | PR |
| A4FUM1 | sept8b | Septin-8-B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q642H3 | sept8a | Septin-8-A | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSAATATAAP | VPPPVGISNL | PNQRYKIVNE | EGGTFTVMLC | GESGLGKTTF | INTLFQTVLK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RADGQQHRQE | PIRKTVEIDI | TRALLEEKHF | ELRVNVIDTP | GFGDNVNNNK | AWQPLVDFID |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DQHDSYMRQE | QQPYRTKKFD | LRVHAVLYFI | RPTGHGLKPI | DIETMKRLST | RANLIPVIAK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ADTLTAQELQ | QFKSRIRQVI | EAQEIRIFTP | PLDADSKEDA | KSGSNPDSAA | VEHARQLIEA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MPFAIVGSEK | KFDNGQGTQV | VARKYPWGLV | EIENDSHCDF | RKLRALLLRT | YLLDLISTTQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EMHYETYRRL | RLEGHENTGE | GNEDFTLPAI | APARKLSHNP | RYKEEENALK | KYFTDQVKAE |
| 370 | 380 | 390 | 400 | ||
| EQRFRQWEQN | IVNERIRLNG | DLEEIQGKVK | KLEEQVKSLQ | VKKSHLK |