Q9R1T4
PR
Gene name |
Septin6 |
Protein name |
Septin-6 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:56526 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9R1T4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9R1T4-F1 | Predicted | AlphaFoldDB |
24 variants for Q9R1T4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389523724 | 27 | S>N | No | EVA | |
| rs3408782117 | 76 | Q>* | No | EVA | |
| rs3389556934 | 105 | F>C | No | EVA | |
| rs3389512724 | 111 | K>Q | No | EVA | |
| rs3389568570 | 136 | I>L | No | EVA | |
| rs217012649 | 182 | V>I | No | EVA | |
| rs3409147896 | 199 | I>M | No | EVA | |
| rs3409491523 | 200 | K>T | No | EVA | |
| rs3389560043 | 218 | D>G | No | EVA | |
| rs3389523678 | 226 | N>S | No | EVA | |
| rs3408699437 | 230 | N>T | No | EVA | |
| rs3409968881 | 267 | A>P | No | EVA | |
| rs3389568533 | 273 | K>SDG* | No | EVA | |
| rs3409858260 | 284 | E>V | No | EVA | |
| rs3410056851 | 285 | D>G | No | EVA | |
| rs3408782173 | 290 | T>I | No | EVA | |
| rs3389534809 | 302 | K>E | No | EVA | |
| rs3389557699 | 303 | L>R | No | EVA | |
| rs3389553150 | 305 | E>D | No | EVA | |
| rs3389571162 | 305 | E>G | No | EVA | |
| rs3389555302 | 305 | E>K | No | EVA | |
| rs3389557733 | 340 | E>D | No | EVA | |
| rs3409750789 | 366 | E>G | No | EVA | |
| rs3389556866 | 375 | H>N | No | EVA |
No associated diseases with Q9R1T4
Functions
13 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon terminus | Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it. |
| cell division site | The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. |
| cleavage furrow | The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm. |
| kinetochore | A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. |
| microtubule cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. |
| midbody | A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. |
| presynapse | The part of a synapse that is part of the presynaptic cell. |
| septin collar | A tubular, hourglass-shaped structure composed of highly ordered arrays of septin filaments; in budding yeast cells, the septin collar forms from the initial septin ring by expanding into the daughter cell. |
| septin complex | A protein complex containing septins. Typically, these complexes contain multiple septins and are oligomeric. |
| septin ring | A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form. |
| sperm annulus | The ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity. |
| spindle | The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. |
| synaptic vesicle | A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| molecular adaptor activity | The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| cilium assembly | The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. |
| cytoskeleton-dependent cytokinesis | A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton. |
| protein localization | Any process in which a protein is transported to, or maintained in, a specific location. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
21 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32468 | CDC12 | Cell division control protein 12 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q07657 | SHS1 | Seventh homolog of septin 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P32457 | CDC3 | Cell division control protein 3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| A2VE99 | SEPTIN11 | Septin-11 | Bos taurus (Bovine) | PR |
| A6QQL3 | SEPTIN14 | Septin-14 | Bos taurus (Bovine) | PR |
| Q3SZN0 | SEPTIN6 | Septin-6 | Bos taurus (Bovine) | PR |
| P54359 | 02-Sep | Septin-2 | Drosophila melanogaster (Fruit fly) | PR |
| Q9NVA2 | SEPTIN11 | Septin-11 | Homo sapiens (Human) | PR |
| Q9P0V9 | SEPTIN10 | Septin-10 | Homo sapiens (Human) | PR |
| Q14141 | SEPTIN6 | Septin-6 | Homo sapiens (Human) | PR |
| P28661 | Septin4 | Septin-4 | Mus musculus (Mouse) | PR |
| Q9DA97 | Septin14 | Septin-14 | Mus musculus (Mouse) | PR |
| Q8CHH9 | Septin8 | Septin-8 | Mus musculus (Mouse) | PR |
| Q8C1B7 | Septin11 | Septin-11 | Mus musculus (Mouse) | PR |
| Q9Z1S5 | Septin3 | Neuronal-specific septin-3 | Mus musculus (Mouse) | PR |
| Q80UG5 | Septin9 | Septin-9 | Mus musculus (Mouse) | PR |
| O55131 | Septin7 | Septin-7 | Mus musculus (Mouse) | PR |
| B0BNF1 | Septin8 | Septin-8 | Rattus norvegicus (Rat) | PR |
| B3GNI6 | Septin11 | Septin-11 | Rattus norvegicus (Rat) | PR |
| A4FUM1 | sept8b | Septin-8-B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q642H3 | sept8a | Septin-8-A | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAADIARQV | GEDCRTVPLA | GHVGFDSLPD | QLVNKSVSQG | FCFNILCVGE | TGLGKSTLMD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TLFNTKFEGE | PATHTQPGVQ | LQSNTYDLQE | SNVGLKLTIV | STVGFGDQIN | KEDSYKPIVE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FIDAQFEAYL | QEELKIRRVL | HSYHDSRIHV | CLYFIAPTGH | SLKSLDLVTM | KKLDSKVNII |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PVIAKSDAIS | KSELAKFKIK | ITSELVSNGV | QIYQFPTDDE | SVSEINGTMN | AHLPFAVVGS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TEEVKIGNKM | MRARQYPWGT | VQVENEAHCD | FVKLREMLIR | VNMEDLREQT | HARHYELYRR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CKLEEMGFKD | TDPDSKPFSL | QETYEAKRNE | FLGELQKKEE | EMRQMFVQRV | KEKEAELKEA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EKELHEKFDR | LKKLHQEEKK | KLEDKKKCLD | EEMNAFKQRK | AAAELLQSQG | SQAGGSQTLK |
| 430 | |||||
| RDKEKKNNPW | LCIE |